Nutrient-dependent Pheromone-controlled cures (1)

By: James V. Kohl | Published on: August 26, 2019

See first: Lewis Thomas (revisited): 90K (7)

The existence of light-activated inter-organism systems of genetic regulation has been relatively ignored for ~25 more years, which is the time it takes to raise another generation of biologically uninformed science idiots.

Moving forward:

I asked on Twitter: Has anyone defined #optoribogenetic modalities in the context of #electrostatic interactions linked to biophysically constrained #coacervates via the #hydrophobicity of oligonucleotide-peptide complexes required for the phase-controlled hybridized maintenance of supercoiled DNA?

In addition to the fact that the attempts to obfuscate cause and effect via use of terms like optoribogenetic and coacervates are obvious, here’s why I asked:

A blue light receptor that mediates RNA binding and translational regulation 8/26/19

The present results elucidate a new signal-transduction paradigm in LOV receptors and conjoin RNA biology with optogenetic regulation, thereby paving the way toward hitherto inaccessible optoribogenetic modalities.

This was reported as: Blue light for RNA control 8/26/19

…the new study now shows for the first time a mechanism by which the interaction between RNA and specific proteins can be influenced by light. Gene expression in bacteria can hence be controlled directly at the level of RNA molecules.

“Blue light for RNA control” is easy to understand when placed into the context of the light-activated assembly of the microRNA-RNA-peptide nanocomplex. But that was placed back into the context of optoribogenetic modalities.

In either case, the light biophysically constrains viral latency in more than 70 blog posts here that mention the  microRNA-RNA-peptide nanocomplex..

Although, the term optoribogenetic  is not commonly used, the invention of the term can also be linked to biophysically constrained viral latency in all living genera via more than 90K indexed published works that mention microRNA.

Clearly, what may be known to the pseudoscientists who invented the term optoribogenetics can be linked from the creation of light-activated divalent cations to heterotypic and homotypic coacervates by searching PubMed for coacervates + microRNA .

Coacervates are organic-rich droplets formed via liquid-liquid phase separation, mainly resulting from association of oppositely charged molecules or from hydrophobic molecules/proteins.

When people learn that the hydrophobicity of the molecules in proteins is pH-dependent, they may realize why:

Divalent cations can control a switch-like behavior in heterotypic and homotypic RNA coacervates. 8/21/19

…divalent ion variations continuously tune the microenvironments and fluid properties of heterotypic and homotypic droplets. Our results may provide a general mechanism for modulating the biochemical environment of RNA coacervates in a cellular context.

Taken together, light-activated optoribogenetic effects on the RNA coacervates can be linked to biophysically constrained viral latency in all living genera via the physiology of reproduction. Taken together, light activated feedback loops link the electrostatic interactions from the assembly of of the microRNA-RNA-peptide nanocomplex to pheromone-controlled constraints of the formation of more ATP-dependent RNA-mediated supercoiled DNA.

For example: Feedback loops link odor and pheromone signaling with reproduction (2005)

See also: Oligonucleotide-Peptide Complexes: Phase Control by Hybridization 1/9/18

Electrostatic interactions are also the primary method used for assembly of nanoparticles to deliver therapeutic nucleic acids into cells.

You can skip the confusing invention of new terms such as coacervates and optoribogenetics when you learn that the light-activated hydrophobicity of supercoiled DNA could not exist outside the context of the Creation of sunlight, water, ATP, microRNA biogenesis, and RNA interference.

RNA interference protects all organized genomes from the virus-driven degradation of messenger RNA that links virus-caused mutations to all diseases.

You can go from the patent for naturally occurring RNA interference directly to Lysine/RNA-interactions drive and regulate biomolecular condensation 7/2/19

We then use synthetic peptides with distinct amino acid content to study molecular properties of phase-separated states formed by lysine- and arginine-rich peptides and show that different lysine-rich sequences of the protein tau undergo complex coacervation with RNA and bind to SGs [stress granules].

Concluding sentence:

In summary, our integrative approach comprising bioinformatic analysis, in vitro phase separation studies, fluorescence microscopy and NMR spectroscopy, together with a cellular SG association assay, establishes lysine as a critical regulator of biomolecular condensation.

My summary: They linked one base pair and one amino acid in a light-assembled microRNA-RNA-peptide nanocomplex to protection from stress-linked virus-driven degradation of messenger RNA, which links mutations to all pathology.

See: Nutrient-dependent Pheromone-controlled cures (2)

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