Nutrient-dependent Pheromone-controlled cures (4)

By: James V. Kohl | Published on: August 30, 2019

Who believes I am losing followers and engagements on Twitter @microRNApro after 3 SNPs were linked from the stability of organized human genomes to homosexual orientation, prevention of suicides and prevention of mass killings via COMT Val158Met (one food energy-dependent pheromone-controlled amino acid substitution)?
Relations between catechol-O-methyltransferase Val158Met genotype and inhibitory control development in childhood 8/1/19
See for comparison: Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior 8/30/19
Reported as: Retiring the “Gay Gene” Hypothesis 8/29/19

One of the SNPs is near genes that affect the sense of smell (for males). Two others are near genes that regulate sex hormones, in females and males. And none were on the X chromosome, for so many years thought to house the debunked gay gene.

The pseudoscientific nonsense about gay gene was presciently debunked in our Hormones and Behavior review of the nature vs nurture controversy. See our section on molecular epigenetics and the Discussion in: From Fertilization to Adult Sexual Behavior (1996)

Parenthetically it is interesting to note even the yeast Saccharomyces cerevisiae has a gene-based equivalent of sexual orientation (i.e., a-factor and alpha-factor physiologies). These differences arise from different epigenetic modifications of an otherwise identical MAT locus (Runge and Zakian, 1996; Wu and Haber, 1995).

See for comparison: Orthogonal monoterpenoid biosynthesis in yeast constructed on an isomeric substrate 8/23/19

A characteristic case, where the establishment of an orthogonal metabolic pathway could be beneficial, is the synthesis of monoterpenoids in Saccharomyces cerevisiae. Monoterpenoids are widely used as flavors, antibacterials, and insecticides10,11, and recently, their applications have expanded to include high-density fuels, renewable polymers, and green plastics12.

They used an enzyme and varying concentrations of substrate to link alternative splicings of pre-mRNAs to an orthogonal pathway for monoterpene scaffold production via amino acid substitutions. They identified a single residue dictating isomeric substrate selectivity in the monoterpene synthase and engineered canonical terpene synthases to specifically accept the alternative substrate.
Simply put, they linked light-activated endogenous substrates called microRNAs to the naturally occurring nutrient-dependent pheromone-controlled physiology of sexual differentiation of cell types in yeasts. That is how they establishes a complete synthetic pathway. The synthetic pathway can be linked to what was known about the naturally occurring pathway via claims from 1964 about oxidative phosphorylation and ATP-dependent RNA synthesis.
Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation”

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

That led them to make the advances that linked monoterpene oxidation to marked improvements in the production of several industrially important monoterpenes. It can be compared to the biological facts about constraints on the virus-driven degradation of messenger RNA that link the physiology of pheromone-controlled reproduction in yeasts to human sexual orientation via conserved molecular mechanisms of epigenetically effected cell type differentiation.
Scientific advances such as this can be compared to the claims about ecologically relevant “magic traits.”
Genetic dissection of assortative mating behavior

Ecologically relevant mating cues (sometimes known as “magic traits” [2,6]) are now predicted to be widespread in nature [6,7], and the last few years have seen considerable progress in our understanding of their genetic basis.

But see: Cancer cell reprogramming 8/29/19
Researchers in China linked microRNAs in milk exosomes to biophysically constrained viral latency and cancer prevention.
For comparison, theorists won’t admit that their theories and mathematical models are useless in today’s world. Your healthy longevity is being held hostage by biologically uninformed science idiots, the terrorists of the Western World.

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