The tipping point (revisited): 91K (1)

By: James V. Kohl | Published on: September 3, 2019

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See first: Trans-kingdom RNA interactions (1)
See also: microRNA See: Items 1 to ~91000
Nanopolystyrene-induced microRNAs response in Caenorhabditis elegans after long-term and lose-dose exposure 8/26/19

…5 miRNAs mediated a protective response to nanopolystyrene… mir-35, mir-38, mir-76, mir-354, and mir-794 were associated with various biological processes and signaling pathways.

The Creation of the signaling pathways is energy-dependent, light-activated, and microRNA-mediated.
The pathways are linked from the nutrient-dependent pheromone-controlled physiology of reproduction in C. elegans to sympatric speciation via what is known about P. pacificus, a predatory nematode with teeth.
Other virus-driven variants linked to mouth development and predation are examined in Two new Species of Pristionchus (Nematoda: Diplogastridae) include the Gonochoristic Sister Species of P. fissidentatus
See also: Integrated mobile genetic elements in Thaumarchaeota 3/18/19

The thaumarchaeal iMGE are all connected within a gene sharing network, highlighting pervasive gene exchange between MGE occupying the same ecological niche. The thaumarchaeal mobilome carries multiple auxiliary metabolic genes, including multicopper oxidases and ammonia monooxygenase subunit C (AmoC), and stress response genes, such as those for universal stress response proteins (UspA). Thus, iMGE might make important contributions to the fitness and adaptation of their hosts. We identified several iMGE carrying type I-B CRISPR-Cas systems and spacers matching other thaumarchaeal iMGE, suggesting antagonistic interactions between coexisting MGE and symbiotic relationships with their archaeal hosts.

Spindle-shaped viruses infect marine ammonia-oxidizing thaumarchaea 7/18/19

…like all microbes, thaumarchaea are infected by viruses and that viral predation has a profound impact on thaumarchaeal functioning and mortality, thereby regulating global biogeochemical cycles.

The links from viral predation to sex differences in human mouth development can be viewed in the context of nutrient-dependent pheromone-controlled sex differences in pathology.
See: Novel role of sex-determining region Y-box 7 (SOX7) in tumor biology and cardiovascular developmental biology 8/29/19

These findings suggest that the alteration of miR-148a expression is an early event in the process of chief cell transdifferentiation into SPEM.

This exemplifies how what is known to conservatives about the light-activated Creation of energy-dependent sex differences in cell types can be compared to how little is known to biologically uninformed science idiots (e.g., liberals and Democrats)
For example, the Creation of sunlight and water links food energy-dependent changes in human microbiomes from the physiology of pheromone-controlled reproduction in bacteria to all biodiversity on Earth. But liberals still place what is known to conservatives about the light-activated assembly of the microRNA-RNA-peptide nanocomplex back into the context of how microbiomes automagically create novel genes.
Simply put, pseudoscientists (liberals and Democrats) claim that what is known to all serious scientists about the creation of peptides is not well-known.

See: Large-Scale Analyses of Human Microbiomes Reveal Thousands of Small, Novel Genes 8/8/19

Knowledge of small peptides encoded by human associated bacteria is very limited.

They refuse to acknowledge the fact that the light-activated assembly of the microRNA-RNA-peptide nanocomplex links the Creation of sunlight and water to biophysically constrained viral latency and healthy longevity via RNA interference, despite the claim from this patent: RNA-Guided Human Genome Engineering

5. Repetitive elements or endogenous viral elements can be targeted with engineered Cas+gRNA systems in microbes, plants, animals, or human cells to reduce deleterious transposition or to aid in sequencing or other analytic genomic/transcriptomic/proteomic/diagnostic tools (in which nearly identical copies can be problematic).

…sheds light on the joint genetic and epigenetic regulation of miRNA expression and provides insights into the relations of miRNAs to their targets and to complex phenotypes.

See also, the refutation of pseudoscientific nonsense that biologically uninformed sex researchers linked from a “gay gene” to human male homosexual behavior.
Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior 8/30/19

Follow-up of these loci suggested links to biological pathways that involve sex hormone regulation and olfaction.

Nutrient-dependent/pheromone-controlled adaptive evolution: a model 6/14/13

…the epigenetic ‘tweaking’ of the immense gene networks that occurs via exposure to nutrient chemicals and pheromones can now be modeled in the context of the microRNA/messenger RNA balance, receptor-mediated intracellular signaling, and the stochastic gene expression required for nutrient-dependent pheromone-controlled adaptive evolution. The role of the microRNA/messenger RNA balance (Breen, Kemena, Vlasov, Notredame, & Kondrashov, 2012; Duvarci, Nader, & LeDoux, 2008; Griggs et al., 2013; Monahan & Lomvardas, 2012) in adaptive evolution will certainly be discussed in published works that will follow.

See also: Sex differences: Liberals vs Conservatives (in prep)
Preview of what is known to biologically uninformed science idiots who link promoters, repressors, and self-replicating ribozymes to gene expression and RNA-mediated cell type differentiation without starting from the Creation of energy, sunlight, water, ATP and RNA.