MicroRNA-mediated, since 1964 (1)

By: James V. Kohl | Published on: September 19, 2019

The [light-activated energy-dependent] enzymatic methylation of RNA and DNA: Effects of bacteriophage infection on the activity of the methylating enzymes (1964)

…might provide a clue as to the biological function of the methylating enzymes.

See for comparison:SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism (11/16/18)

Has anyone else linked the Creation of differences in the energy of two photons from one- carbon metabolism and naturally occurring fluorescence in P. fluorescens to the forthcoming cure for cancer reported by AEBI?

McEwen et al., (1964) excepted. They presciently linked the light-activated assembly of the microRNARNApeptide nanocomplex to biophysically constrained viral latency.

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

But also, don’t forget: Richardson et al., (1964) A DEOXYRIBONUCLEIC ACID PHOSPHATASE-EXONUCLEASE FROM ESCHERICHIA COLI. II. CHARACTERIZATION OF THE EXONUCLEASE ACTIVITY.

See also:  Lehman and Nussbaum (1964) The Deoxyribonucleases of Escherichia coli : V. ON THE SPECIFICITY OF EXONUCLEASE I

In 1974, I began a 40-year career as a medical laboratory scientist. I never learned to doubt the fact that the molecular mechanisms of RNA-mediated cell type differentiation are conserved across kingdoms via the nutrient-dependent pheromone-controlled physiology of reproduction in species from microbes to mammals?

See for comparison: Cellular redox state constrains serine synthesis and nucleotide production to impact cell proliferation (9/1/19)

The researchers touted the de novo serine synthesis pathway linked to NAD+.

They reported that NAD+

…is an endogenous limitation for cancer cells to synthesize the serine needed for purine production to support rapid proliferation.

The energy-dependent microRNA-mediated cellular redox state links NAD+ to biophysically constrained viral latency in the context of everything known to serious scientists about physics, chemistry, and the molecular mechanisms of energy-dependent cell type differentiation.

If you believe in the de novo serine synthesis pathway, you will continue to be ridiculed by all serious scientists.


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