Chemogenetic kinetics (7): DHA vs consensus (1)

By: James V. Kohl | Published on: September 26, 2019

The One Science Lesson Every American Adult Can Learn From Greta Thunberg 9/26/19

Spoiler: it’s to take the advice of bona fide experts, and the scientific consensus (where one exists), in policymaking. Especially when the entire world is at stake.

I wrote: No. The lesson to be learned is: When all else fails to convince people of a lie, hire a 16 y /o girl to throw a fit and hope biologically uninformed science idiots will continue to ignore the facts, since she offered no solutions. Focus on emotions, not science. Be the libtard.

In his latest article, Ethan Siegel claims that the mechanism of genetic mutation and natural selection support the consensus theory on the origin of all extant species on Earth. He skips past claims of how the virus-driven degradation of messenger RNA has linked mutations to all extinctions and uses the emotional outbursts of a 16 year-old girl to support these claims.

  1. The science has been unambiguous since the late 1980s: the Earth is warming, humans are the cause, and the only way to combat this is through large-scale action taken by our world’s governments.
  2. It’s time for real action, and long past time to vote out any impostors that can’t get on board with the scientific consensus.

But see: Hydrophobic catalysis and a potential biological role of DNA unstacking induced by environment effects 8/14/19

Abstract excerpts:

The main stabilizer of the DNA double helix is not the base-pair hydrogen bonds but coin-pile stacking of base pairs, whose hydrophobic cohesion, requiring abundant water, indirectly makes the DNA interior dry so that hydrogen bonds can exert full recognition power.

Hydrophobic base stacking is a major contributor to DNA double-helix stability. We report the discovery of specific unstacking effects in certain semihydrophobic environments.

We propose that a modulated chemical potential of water can promote “longitudinal breathing” and the formation of unstacked holes while base unpairing is suppressed.

Further information about unstacking dynamics is obtained from the binding kinetics…

We speculate that such hydrophobic interactions may have catalytic roles also in other biological contexts, such as in polymerases.

Reported as DNA is held together by hydrophobic forces 9/23/19

Researchers at Chalmers University of Technology, Sweden, disprove the prevailing theory of how DNA binds itself. It is not, as is generally believed, hydrogen bonds which bind together the two sides of the DNA structure. Instead, water is the key. The discovery opens doors for new understanding in research in medicine and life sciences.

The Creation of sunlight and water is the key to this chemogenetic approach to the function of RNA and functional structure of supercoiled DNA.

See also:  A chemogenetic approach to RNA function/structure analysis 6/11/99

Nucleotide Analog Interference Mapping… made it possible to determine the chemical basis of RNA function and structure, including the identification of new rules for RNA helix packing, the functional analysis of a binding site for monovalent metal ions within RNA and the characterization of the catalytic mechanism of RNA enzymes.

For comparison, see: MicroRNA based feedforward control of intrinsic gene expression noise 8/30/19

…the strong coupling between mRNA and microRNA in the sense of burst stoichiometry and also of timing of production events renders the microRNA based feedforward motif an effective mechanism for the control of gene expression noise.

Moving forward, see: Projected declines in global DHA availability for human consumption as a result of global warming 9/12/19

Solutions are needed to slow the rate of DHA loss in order to protect this valuable, patchily distributed, resource for future human generations and ecosystems.

AND Chemogenetic kinetics (7): DHA vs consensus(2)


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