#SFN2019 to 2012: Hiding the facts (3)

By: James V. Kohl | Published on: October 18, 2019

Why Immune Cells Extrude Webs of DNA and Protein 10/1/19

Plant root cells release chromatin to defend against pathogens, and a recent study described NET-like structures released from phagocytes of invertebrates, such as crabs, mussels, and anemones. The process of cells releasing their DNA as a protective mechanism might therefore be ancient. Further studies will hopefully identify the origin of NETs, and thereby shed light on this fascinating and important process.

Combating Evolution to Fight Disease 3/7/14

The evolutionary biologist Theodosius Dobzhansky famously noted that “nothing in biology makes sense except in the light of evolution,” but perhaps, too, “nothing in evolution makes sense except in the light of biology.” Although the latter might be an exaggeration, an important gap is being filled by molecular understanding of the genesis of variation that confers the ability to evolve.

The light-activated assembly of the microRNA-RNA-peptide nanocomplex enables the link from the Creation of anti-entropic virucidal light and the Creation of water to the genesis of all oxygen-dependent ecological adaptations across kingdoms. Placing light-activated microRNA biogenesis back into the context of something that confers the ability to evolve exemplifies human idiocy.
For comparison see:
Light-regulated collective contractility in a multicellular choanoflagellate 10/18/19

C. flexa colonies are each composed of a monolayer of polarized cells. In response to sudden darkness, a light-sensing protein triggers coordinated, polarized contraction of C. flexa cells, which results in colony inversion. The cellular mechanisms underlying this process are conserved between C. flexa and animals, indicating that their last common ancestor was also capable of polarized cell contraction.

No. That fact indicates their last common ancestor sensed light and linked its anti-entropic virucidal effect on cell type differentiation from the physiology of reproduction to biophysically constrained viral latency and the genesis of all biodiversity on Earth.
For an example from plant growth, see:
Root microbiota assembly and adaptive differentiation among European Arabidopsis populations

…we uncoupled soil from location effects and tested their respective contributions to root microbiota variation and plant adaptation. The composition of the root microbiota was affected by location and soil origin, and to a lesser degree by host genotype. The filamentous eukaryotes were particularly strongly affected by location. Strong local adaptation between the two A. thaliana populations was observed, with difference in soil properties and microbes of little importance for the observed magnitude of adaptive differentiation. Our results suggest that, across large spatial scales, climate is more important than are soil conditions for plant adaptation and variation in root-associated filamentous eukaryotic communities.

Nothing ‘evolved.”
See also: Adaptation to Plant Communities across the Genome of Arabidopsis thaliana 4/11/19

…dissecting the genetic basis underlying plant-plant interactions at a regional scale while controlling for abiotic confounding factors can help understanding the adaptive mechanisms modulating natural plant assemblages.

Natural plant assemblages do not ‘evolve.’
See also: MicroRNA delivery through nanoparticles 10/14/19

This review critically discusses the use of nanoparticles for the delivery of miRNA-based therapeutics in the treatment of cancer and neurodegenerative disorders and for tissue regeneration. A fresh perspective is presented on the design and characterization of nanocarriers to accelerate translation from basic research to clinical application of miRNA-nanoparticles.

This fresh perspective on the ability to deliver microRNAs via the light-activated assembly of the microRNA-RNA-peptide nanocomplex assures all serious scientists that no species ever ‘evolved’ into another species. Organisms adapt or the virus-driven degradation of messenger RNA causes them to descend and become archaea and L-forms, cells without walls.
Nothing ‘evolves’ except pathology.
See  Virus-mediated archaeal hecatomb in the deep seafloor for comparison to  Eukaryotic plankton diversity in the sunlit ocean
And, see the patent for the cancer cure:
Methods and compositions for identifying a peptide having an intermolecular interaction with a target of interest 12/25/18

A system of a recombinant bacteriophage library and a target of interest complex, wherein the recombinant bacteriophage peptide library includes a plurality of peptides expressed on the surface of recombinant bacteriophages wherein each recombinant bacteriophage includes (a) a pill protein; wherein each pill protein includes (b) a peptide or polypeptide involved in an intermolecular interaction, which differs by at least one amino acid from other peptides or polypeptides in the library; and (c) a modified protease cleavage site proximal to the peptide, wherein the modified protease cleavage site is the same in each bacteriophage, the modified cleavage site having a reduced binding affinity to a protease, as compared to a non-modified cleavage site, and wherein the target of interest complex includes a protease, a flexible linker attached to the protease, and a target of interest attached to the flexible linker, wherein the target of interest participates in an intermolecular interaction.

Intermolecular interactions are energy-dependent. Sunlight is the source of that energy.
Proof of concept

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