MicroRNAs biophysically constrain Virus-driven pathology (6)

By: James V. Kohl | Published on: December 3, 2019

Summary: The fact that autophagy biophysically constrains energy-dependent viral latency and healthy longevity has gone missing from the pseudoscientific nonsense touted by neo-Darwinian theorists, Big Bang cosmologists and the claims of biologically uninformed science idiots who must now use the term geovirology in an attempt to mislead those who know nothing about the geobiology of life on Earth.
Historical Perspective on theoretical Geobiology: (There is no historical perspective on geoviology) Your search for geovirology retrieved no results.
See for comparison, the facts about the Creation of enzymes.
Structural Dynamics and Mechanochemical Coupling in DNA Gyrase 5/8/16

Gyrase is a molecular motor that harnesses the free energy of ATP hydrolysis to perform mechanical work on DNA. The enzyme specifically introduces negative supercoiling in a process that must coordinate fuel consumption with DNA cleavage and religation and with numerous conformational changes in both the protein and DNA components of a large nucleoprotein complex. Here we present a current understanding of mechanochemical coupling in this essential molecular machine, with a focus on recent diverse biophysical approaches that have revealed details of molecular architectures, new conformational intermediates, structural transitions modulated by ATP binding, and the influence of mechanics on motor function. Recent single-molecule assays have also illuminated the reciprocal relationships between supercoiling and transcription, an illustration of mechanical interactions between gyrase and other molecular machines at the heart of chromosomal biology.

The energy-dependent Creation of enzymes was required for genome organization and transcription in all organisms.
See: Microscopy-based chromosome conformation capture enables simultaneous visualization of genome organization and transcription in intact organisms 10/3/18 and 2/19/19

Hi-M simultaneously reveals 3D chromatin organization and transcriptional activity

Chromatin organization and transcriptional activited are energy-dependent and microRNA-mediated via the Creation of enzymes such as gyrase. Energy-dependent microRNA biogenesis biophysically constrains viral latency via the light-activated assembly of the microRNA-RNA-nanocomplex, which links the Creaton of enzymes to protection from the virus-driven degradation of messenger RNA that links mutations to all pathology.
See for review:

MicroRNA biogenesis protects us from HERVs (1) 10/25/18
MicroRNA biogenesis protects us from HERVs (2) 10/26/18
MicroRNA biogenesis protects us from HERVs (3) 10/26/18
The light-activated Creation of one enzyme linked from autophagy to biophysically constrained RNA interference and viral latency links the Biological Function of Autophagy to healthy longevity in all living genera. The facts about how enzyme-dependent molecular mechanisms must link the Creation of sunlight and water to all oxygen-dependent ecological adaptations have, until recently, been obfuscated by the overwhelming ignorance of researchers, including those who wrote the review on DNA gyrase. They are focused on drug development, not on naturally occurring energy-dependent fixation of amino acid substitutions and healthy longevity.
See also: Cryo-EM structure of the complete E. coli DNA gyrase nucleoprotein complex 10/30/19
They linked the energy-dependent creation of amino acid substitutions from the cryo-EM structure of the complete E. coli DNA gyrase nucleoprotein to ‘evolutionary conservation’ of the ATPase/transducer structure and a phylogenetic tree.
In reality, they linked God’s Creation of energy from His Creation of ATP and the Creation of water to His oxygen-dependent Creation of RNA and biophysically constrained viral latency via the Biological Function of Autophagy
See for review: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” (1964)

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

The fact that autophagy and the Creation of RNA are ATP-dependent has been clear to all serious scientists since the time when Schrodinger published What is Life? (1944)

Indeed, in the case of higher animals we know the kind of orderliness they feed upon well enough, viz. the extremely well-ordered state of matter in more or less complicated organic compounds, which serve them as foodstuffs. After utilizing it they return it in a very much degraded form -not entirely degraded, however, for plants can still make use of it. (These, of course, have their most power supply of ‘negative entropy’ the sunlight.) (pp. 73 and 74)

See also the reprint for the comment in the forward by Roger Penrose who co-authored with George F.R. Ellis and Stephen Hawking
How often do we still hear that quantum effects can have little relevance in the study of biology, or even that we eat food in order to gain energy?” (Roger Penrose 8 August 1991)
See: Biological Function of Autophagy (1)

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