mRNA Structure and Function (1)

By: James V. Kohl | Published on: December 11, 2019

The light-activated assembly of the microRNA-RNA-peptide nanocomplex is being commercialized and biologically uninformed theorists missed it. How stupid is that?
For other information on what the theorists missed, see:
Codon identity regulates mRNA stability and translation efficiency during the maternal‐to‐zygotic transition  7/9/16

Codon identity regulates mRNA stability and translation efficiency during the maternal-to-zygotic transition , it is likely that this code integrates multiple inputs of translation from tRNA availability and accuracy (Akashi, 1994; Ishimura et al, 2014; Hussmann et al, 2015), tRNA modification (Gustilo et al, 2008; Novoa et al, 2012), to peptide bond formation, amino acid identity, and other factors influencing the translocation rate and ultimately elongation.

mRNA does not Create itself.
See for review:  Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” (1964)

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

The role that oxidative phosphorylation plays in RNA-mediated cell type differentiation has been detailed since 1964.
See: Strong anion exchange-mediated phosphoproteomics reveals extensive human non-canonical phosphorylation 8/21/19

It is very well established that post‐translational modification (PTM) of proteins by phosphorylation rapidly and reversibly regulates cellular signalling functions, impinging on catalytic activity, protein:protein/DNA/RNA interactions, protein localisation and stability (Cohen, 2002; Hunter, 2012).

Because oxygen is required for oxidative phosphorylation and non-canoniacal phosphorylation of amino acids that biophysically constrain viral latency, see also:
Cerebral oxygenation during locomotion is modulated by respiration 12/4/19
Reported as:  Respiration key to increase oxygen in the brain 12/4/19
The fact that exercise causes people to breathe faster to increase oxygen levels in the brain led to this claim.
Nature and nurture does not just mean genes and environment. Development introduces a third source of variation. — Kevin J Mitchell
The third source of variation during development is light-activated microRNA biogenesis, which must be linked from biophysically constrained viral latency to all biodiversity on Earth via the physiology of reproduction.
Since the time he published “Innate How the Wiring of Our Brains Shapes Who We Are” Kevin J Mitchell has “seen the light of Creation.”
See for comparison my review of his overwhelming ignorance: Ignoring light-activated microRNA biogenesis 10/16/18
Book Review of “Innate How the Wiring of Our Brains Shapes Who We Are” by Kevin J Mitchell

He frames his claims in the context of random mutations and evolved biodiversity despite the facts that serious scientists have detailed. For example, ages 10+ can learn how the creation of subatomic particles must be linked from cytosis to biophysically constrained viral latency and sympatric speciation.

The physiology of reproduction is linked to heredity in species from soil bacteria to humans via EDAR V370A (an amino acid substitution) in mice; in populations found in North and East Asia; and in populations in the New World.

I could go on about the facts about cell type differentiation for hours or refer you to MicroRNA.pro or one of my other domains. Alternatively, you could see the work that was published today: “MicroRNAs buffer genetic variation at specific temperatures during embryonic development” for comparison to our 1996 review of molecular epigenetics: “From Fertilization to Adult Sexual Behavior”

 

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