Bruce McEwen’s legacy: sympatric speciation (3)

By: James V. Kohl | Published on: January 5, 2020

Recent additions to the available information on energy-dependent microRNA-mediated cause and effect can be found in:  Bruce S. McEwen’s legacy: sympatric speciation (2)
Moving forward: On the day after Bruce S. McEwen died, the preprint for Integrated analysis of directly captured microRNA targets reveals the impact of microRNAs on mammalian transcriptome 6/15/19 was published in “RNA,” the flagship journal for the RNA Society,
The so-called ‘integrated analysis‘ links everything known about light-activated microRNA biogenesis to the physiology of reproduction and sympatric speciation. That is how what’s known about biophysically constrained viral latency is linked to healthy longevity  across kingdoms.
The integrated analysis also links the virus-driven degradation of messenger RNA from constraint-breaking mutations to all pathology.
For Bruce McEwen’s historical perspective on the integrated analysis, see: Effects of Carnitine on Fatty-Acid Oxidation by Muscle (1959)

…it is relevant to ask by what means serum fatty acids are transported from blood vessels through the interstitial space to the active sites for fatty-acid oxidation in muscle cells.

Other intelligent serious scientists, who were more like Bruce McEwen than they knew, also asked how the transport could be biophysically constrained in the context of the transgenerational epigenetic inheritance of all morphological and behavioral phenotypes.
That question was answered in: Pheromones: a new term for a class of biologically active substances (1959)

Pheromones are defined as substances which are secreted to the outside by an individual and received by a second individual of the same species, in which they release a specific reaction, for example, a definite behavior, or a developmental process.

The fact that pheromones control specific reactions to definite behaviors during developmental processes inspired McEwen et al., to publish Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” in 1964 with this claim.

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

Speculation in Schrodinger’s “What is life?”(1944) probably led McEwen et al., to assert an understated fact, which was perfectly clear to all other serious scientists.
Clearly, energy-dependent changes in the Creation of RNA were required to link feedback loops to the structural diversity of supercoiled DNA, if only because RNA does not create itself.
For comparison, theorists have continued to place what is known to all serious scientists back into the context of gene-centric theories via genome wide association studies (GWAS) and their overwhelming ignorance of the experimental evidence linked to biophysical constraints.
See: Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits 1/3/20

Genome-wide association studies (GWAS) with clinically relevant intermediate traits, such as gene expression1, proteomics2, and metabolomics3, unraveled numerous pathophysiological pathways and generated many hypotheses regarding the functional basis of complex disorders4.

The question arises: Will facts about microRNA-mediated biophysically constrained RNA interference from the Cold Spring Harbor Laboratory Press preprint and publication in “RNA” prevail, or will the obfuscation of facts about top-down causation from the “Nature Publications Group” prevail?
For the most likely answer, see: Why have microRNA biomarkers not been translated from bench to clinic? 1/17/19

It is important to focus on upregulated miRNAs rather than the downregulated miRNAs. Finally, a panel of selected miRNAs, instead
of a single one, could be more effective to guarantee that the biomarker is specific to a cancer.

Upregulated microRNAs (miRNAs) are nutrient-dependent and pheromone-controlled in species from microbes to humans. The virus-driven degradation of messenger RNA links the downregulation of microRNAs from mutations to all pathology via changes in base pairs linked to biophysically constrained fixation of RNA-mediated amino acid substitutions. There’s a model for that! The model is based on the works of serious scientists such as Bruce S. McEwen.
For comparison, see: Biology, molecular and organismic (1964)

The notion has gained some currency that the only worthwhile biology is molecular biology. All else is “bird watching” or “butterfly collecting.” Bird watching and butterfly collecting are occupations manifestly unworthy of serious scientists!

For more ridicule of theorists, see:

 


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