MicroRNA-mediated healthy longevity (1)

By: James V. Kohl | Published on: January 9, 2020

1/9/20 Selected additions from my PubMed search for: microRNA
Too many additions link energy-dependent changes in microRNA biogenesis from the virus-driven degradation of messenger RNA to cancer.
See for example:

  1. GALE Promotes the Proliferation and Migration of Glioblastoma Cells and Is Regulated by miR-let-7i-5p
  2. Epidemiological evidence for associations between variants in microRNA or biosynthesis genes and lung cancer risk
  3. microRNA-181 serves as a dual-role regulator in the development of human cancers
  4. Research progress on the interactions between long non-coding RNAs and microRNAs in human cancer
  5. Specific Inhibition of Viral MicroRNAs by Carbon Dots-Mediated Delivery of Locked Nucleic Acids for Therapy of Virus-Induced Cancer

For specific virus-caused cancers, use this search strategy: microRNA _____   cancer (there are more than 44,000 selections that may lead you to results for a specific type of cancer)
For example: Three-microRNA expression signature predicts survival in triple-negative breast cancer.
My focus will continue to be on disease prevention or effective treatments of virus-driven diseases, which have been linked from Microbiome-Association Studies (MAS) to elimination of the pseudoscientific nonsense touted in Genome-Wide Association Studies (GWAS) by at least three patents for energy-dependent microRNA-mediated RNA interference and the pheromone-controlled physiology of reproduction in species from microbes to humans
See also:
Extracellular vesicles released by melanocytes after UVA irradiation promote intercellular signaling via miR21
miR-199 plays both positive and negative regulatory roles in Xenopus eye development
Expression of selected angiogenesis-related small microRNAs in patients with abnormally increased secretion of glucocorticoids.
BcpLH organizes a specific subset of microRNAs to form a leafy head in Chinese cabbage (Brassica rapa ssp. pekinensis)
MiR-144 protects the heart from hyperglycemia-induced injury by regulating mitochondrial biogenesis and cardiomyocyte apoptosis
Systems biology approaches toward autosomal dominant polycystic kidney disease (ADPKD).
MicroRNA-mediated responses to colchicine treatment in barley
Elucidating the regulatory roles of microRNAs in maize (Zea mays L.) leaf growth response to chilling stress
MicroRNA-26a/b have protective roles in oral lichen planus

…vitamin D/VDR-induced miR-26a/b take protective functions in OLP via both inhibiting apoptosis and impeding inflammatory response in oral keratinocytes.

Biomarkers in VSMC phenotypic modulation and vascular remodeling
Analysis of Small RNAs of Barley Genotypes Associated with Resistance to Barley Yellow Dwarf Virus

Insights into the expression patterns of miRNAs in response to BYDV in barley provided here will benefit further studies toward understanding the resistance mechanisms and developing novel strategies against virus infections.

MicroRNAs: Biological Regulators in Pathogen-Host Interactions
MicroRNAs and Metastasis.
Epigenetic Changes in Asthma: Role of DNA CpG Methylation.
Let-7e-5p regulates GLP-1 content and basal release from enteroendocrine L cells from DIO male mice

Using miRNA inhibitors and mimics we observed that modulation of let-7e-5p expression affected specifically GLP-1 cellular content and basal release, whereas Gcg gene expression as well as acute GLP-1 secretion and cell proliferation were not affected.

In 2012, at the annual meeting of the Society for Neuroscience, few people knew that enteroendocrine cells existed. Diego Bohoroquez and I shared a few laughs about that. We briefly discussed the fact that the enteroendocrine cells were required to link the metabolism of food from the gut microbiome and Microbiome-Association Studies to every aspect of morphological and behavioral biodiversity in organisms that ate other organisms to successfully reproduce via sympatric speciation.
See: Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells (2015)
Reported as Researchers map direct gut-brain connection 1/6/15

It was a leap of faith, said Bohórquez, but it worked. A week after introducing the virus, only cells with neuropods became infected.

“That provides a pathway where rabies can go from the lumen of the gut to the nervous system,” said Rodger Liddle, who is a member of the Duke Institute for Brain Sciences. “It implies you might be able to get rabies by eating rabies. Maybe this is a pathway whereby other viruses could infect the nervous system.”

The new study focused on connections between neuropods and neurons closest to the intestine, but the team is now working to trace the whole path from the gut to brain.

My focus has always been on nutrient-dependent pheromone-controlled epigenetic changes linked from ecological variation to ecological adaptations in species from microbes to humans.
See for instance: Epigenetic alterations of testicular germ cell tumours
Indeed, LH: The link between sex and the sense of smell? was the title of the first presentation I made to a scientific forum in 1992.
See: miR-7 mediates the signaling pathway of NE affecting FSH and LH synthesis in pig pituitary 1/1/20

These suggest that miR-7 mediates NE’s effect on promoting FSH and LH synthesis in porcine pituitary.

See for disease predictions: Neural Inductive Matrix Completion with Graph Convolutional Networks for miRNA-disease Association Prediction 1/6/20
For disease predictions and prevention across kingdoms, see:
Suppression of long noncoding RNA NEAT1 attenuates hypoxia-induced cardiomyocytes injury by targeting miR-378a-3p
CDR1as/miRNAs-Related Regulatory Mechanisms in Muscle Development and Diseases.
miR-10 involved in salinity-induced stress responses and targets TBC1D5 in the sea cucumber, Apostichopus japonicas
miR-133a-3p/FOXP3 axis regulates cell proliferation and autophagy in gastric cancer
In case you didn’t know, autophagy biophysically constrains viral latency. See Autophagy.pro
Moving forward:
microRNA-141 inhibits TGF-β1-induced epithelial-to-mesenchymal transition through inhibition of the TGF-β1/SMAD2 signalling pathway in endometriosis
RNA Nanotechnology-Mediated Cancer Immunotherapy
The Emerging Link between the Hippo Pathway and Non-coding RNA.

The Hippo intracellular signaling pathway plays a pivotal role in cell fate determination.

MircroRNA-10b Promotes Human Embryonic Stem Cell-Derived Cardiomyocyte Proliferation via Novel Target Gene LATS1
MicroRNAs Cause Accelerated Decay of Short-Tailed Target mRNAs.
Identifying the differentially expressed microRNAs in autoimmunity: A systemic review and meta-analysis
Integrated analysis of directly captured microRNA targets reveals the impact of microRNAs on mammalian transcriptome
Influence of mesenchymal stem cell-derived extracellular vesicles in vitro and their role in ageing
Therapeutic potential of antagomiRs in haematological and oncological neoplasms
Role of microRNAs in antiviral responses to dengue infection
MicroRNAs in tumor immunity: functional regulation in tumor-associated macrophages
A novel miRNA located in the GATA4 gene regulates the expression of IGF-1R and AKT1/2 genes and controls cell proliferation
Severe obstructive sleep apnea is associated with circulating microRNAs related to heart failure, myocardial ischemia, and cancer proliferation
Gene Ontology: A Resource for Analysis and Interpretation of Alzheimer’s Disease Data
Noncoding RNAs in Atrial Fibrillation: Current Status and Prospect
miR-335 modulates Numb alternative splicing via targeting RBM10 in endometrial cancer
Role of microRNAs in remodeling the tumor microenvironment (Review)
miR‑222 regulates brain injury and inflammation following intracerebral hemorrhage by targeting ITGB8
miR‑146a improves hepatic lipid and glucose metabolism by targeting MED1
Curcumin rescues breast cells from epithelial‑mesenchymal transition and invasion induced by anti‑miR‑34a
See for comparison: MicroRNA-mediated healthy longevity (2)
I will list and/or comment on the recent news reports that fail to mention what is known about microRNA-mediated viral latency and/or fail to link it to healthy longevity. Facebook censors have threatened to block me from distributing any information that might limit the income Facebook makes by marketing pseudoscientific nonsense. MicroRNA-mediated healthy longevity (1) and MicroRNA-mediated healthy longevity (2) will attest to their treachery.

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