Viral microRNA-mediated pathology (1)
(click to enlarge)These cells increase in number in the aging brain, and are induced by viral infections…
For the patented treatment with naturally occurring energy-dependent biophysically constrained RNA interference, see:
RNA-Guided Human Genome Engineering
5. Repetitive elements or endogenous viral elements can be targeted with engineered Cas+gRNA systems in microbes, plants, animals, or human cells to reduce deleterious transposition or to aid in sequencing or other analytic genomic/transcriptomic/proteomic/diagnostic tools (in which nearly identical copies can be problematic).
The patented naturally occurring energy-dependent RNA-mediated treatment refutes neo-Darwinian theories and the claims of Big Bang cosmologists.
See: The oldest virus ever sequenced comes from a 7,000-year-old tooth 5/9/18
See also: A New Discovery Upends What We Know About Viruses 3/14/19
…viruses prove that they’ve had the evolutionary time to try just about every reproductive strategy…
Science journalists and pseudoscientists missed the facts about viral microRNAs.
See: Â Viral MicroRNA 1 – 81 entries with examples from the past 23.5 years of scientific progress
5/1/06 – 1/9/20
RNA interference and HIV-1: hits and misses 5/1/06
We review how viruses might control and regulate host genes by encoding viral microRNA.
Viral MicroRNAs: Interfering the Interferon Signaling 1/9/20
Role of v-miRs in the viral pathogenesis is emerging as demonstrated by their function in subverting host defense mechanisms and regulating fundamental biological processes such as cell survival, proliferation, modulation of viral life-cycle phase.
Immunomodulatory roles of human herpesvirus-encoded microRNA in host-virus interaction
Herpesviruses and MicroRNAs: New Pathogenesis Factors in Oral Infection and Disease?
Viral miRNAs Alter Host Cell miRNA Profiles and Modulate Innate Immune Responses
Lactic Acid Downregulates Viral MicroRNA To Promote Epstein-Barr Virus-Immortalized B Lymphoblastic Cell Adhesion and Growth
The Mechanism of Synchronous Precise Regulation of Two Shrimp White Spot Syndrome Virus Targets by a Viral MicroRNA
A viral microRNA downregulates metastasis suppressor CD82 and induces cell invasion and angiogenesis by activating the c-Met signaling
Presence of Viral microRNA in Extracellular Environments
…viral miRNAs may become packaged into extracellular vesicles, including exosomes, from virally infected cells, contributing to increased stability and prolonged half-life, thereby promoting their utility as a potential biomarker….. Therefore, the detection of several viruses, including KSHV and EBV, in human body fluids via qPCR analysis of viral miRNAs is a strong diagnostic platform and should be considered as a new gold standard for diagnosis of occult viral infections.
