The tipping point (revisited): 97K (2)

A worker placement and dice drafting game built upon Gregor Mendel’s work with genetics and pea plants.

MicroRNA-889 Inhibits Autophagy To Maintain Mycobacterial Survival in Patients with Latent Tuberculosis Infection by Targeting TWEAK

Autophagy plays an important role in protecting the host …. Mycobacterium tuberculosis can suppress autophagy…

Biologically uninformed theorists can’t seem to link the virus-driven degradation of mRNA from failed autophagy to all pathology.
See for comparison: Skin Biomechanics and miRNA Expression Following Chronic UVB Irradiation

miRNAs may play a pivotal role in regulating extracellular matrix deposition and skin biomechanics following chronic UVB exposure…

That claim links God’s Creation of sunlight and water to microRNA-mediated cell type differentiation across kingdoms.
To evaluate virus-driven pathology, see:

Developing a virus-microRNA interactome using cytoscape (2020)

This approach may be applied to any oncogenic virus to map its regulatory functions, and its secondary impact on gene regulation via microRNAs.

Do not try to link microRNA biogenesis to all biodiversity via the physiology of reproduction if you are a biologically uninformed theorist who does not know that gene regulation is microRNA-mediated.
To move forward via cures for diseases, see: Time-Course Transcriptome Analysis of Gingiva-Derived Mesenchymal Stem Cells Reveals That Fusobacterium nucleatum Triggers Oncogene Expression in the Process of Cell Differentiation

…an anaerobic oral commensal and a periodontal pathogen associated with a wide spectrum of human diseases.

This links microbiome-association studies (MAS) to refutations of pseudoscientific nonsense from genome-wide association studies (GWAS).
For review, see: The predictive power of the microbiome… and anything published since 1964 on energy-dependent biophysically constrained RNA interference.
Direct interaction analysis of microRNA-351-5p and nuclear scaffold lamin B1 mRNA by the cell-free in vitro mRNA/miRNA binding evaluation system
As anticipated, they linked energy-dependent changes in the microRNA/mRNA balance from lamin via this fact:

…the interaction of miR-351-5p/lamin B1 mRNA was suppressed by an miR-351-5p inhibitor.

See also: Circular RNA and Diabetes: Epigenetic Regulator with Diagnostic role
They linked microRNA biogenesis to healthy longevity. Now they

…reviewed research on circular RNAs involved in the pathogenesis and diagnosis of diabetes and their prognostic roles.

For a discussion attempt, see:
Genotype: A Mendelian Genetics Game» Forums » General

Subject: How thematic is this?

Re:

…a “Science Behind” document stretch goal that will talk about… how mutations actually work and the in-game connection.”

See also from 6/27/13

For links from the scent of flowers such as petrunias to biophysically constrained learning and memory.

How odor cues help to optimize learning during sleep in a real life-setting 1/27/20

…who would have thought that our nose can significantly help with this?

Reported as The scent of a rose improves learning during sleep 1/31/20

See also: The Scent of Eros: Mysteries of Odor in Human Sexuality (1995/2002)

See for comparison: Feedback loops link the energy-dependent Creation of physical constraints on life from the sense of smell in bacteria to our visual perception of energy & mass and biophysical constraints on biodiversity via the physiology of reproduction.
See: Olfaction Warps Visual Time Perception 3/17/17
Genotype: A Mendelian Genetics Game» Forums » General

“…a “Science Behind” document stretch goal that will talk about… how mutations actually work and the in-game connection.”

Constraint-breaking mutations have been linked to all diseases via: Virus-mediated archaeal hecatomb in the deep seafloor and the new #coronavirus crisis.
For comparison, Eukaryotic plankton diversity in the sunlit ocean links God’s Creation of sunlight and water to all biophysically constrained oxygen-dependent ecological adaptations via the physiology of reproduction across kingdoms.

Contradicting prevalent view, UCI oceanographers predict increase in phytoplankton 1/27/20

The climate change hoax was also revealed in the patent for naturally occurring light-activated carbon fixation and selection for codon optimality linked to RNA interference by Geroge M. Church et al., in  RNA-Guided Human Genome Engineering

See: Epigenetic Regulation of Excitatory Amino Acid Transporter 2 in Neurological Disorders (2019) See also:  Feedback Loops Link Odor and Pheromone Signaling with Reproduction (2005)

Don’t hate theory killers.