The tipping point (revisited): 98K (2)

By: James V. Kohl | Published on: February 12, 2020

microRNA 1-97904 on Darwin Day 2020
God’s Creation of anti-entropic virucidal light and His Creation of water were linked to water homeostasis via microRNA biogenesis, the creation of RNA and vasopressin synthesis, which have been linked from RNA interference to biophysicially constrained viral latency across kingdoms to the prevention or effective treatment of all virus-driven pathology.
See: MicroRNA-132 controls water homeostasis through regulating MECP2-mediated vasopressin synthesis  01/5/18
Chapter Six – Regulation of aquaporin-2 by RNA interference 10/18/19

…we have shown that several miRNAs are responsive to arginine vasopressin or aldosterone stimulation in mouse cortical collecting duct mpkCCD cells.

The link from nutrient stress and or social stress can be viewed in the context of A mysterious 80 nm amoeba virus with a near-complete “ORFan genome” challenges the classification of DNA viruses 1/28/20
Reported as: Odd Little Virus on Darwin Day 2020, February 12.

“…Yaravirus represents a new lineage of viruses isolated from A. castellanii cells. The amount of unknown proteins composing the Yaravirus particles reflects the variability existing in the viral world and how much potential of new viral genomes are still to be discovered.”

The fact that energy-dependent microRNA biogenesis and RNA interference protect all organized genomes from the virus-driven degradation of messenger RNA continue to be placed back into the ridiculous context of neo-Darwinian evolutionary theories.
See for example: Chapter One – Perspectives on the evolution of aquaporin superfamily

Aquaporins (AQPs) belong to a transmembrane protein superfamily composed of an internal repeat of a three membrane-spanning domain and each has a highly conserved NPA box. Based on the more variable carboxyl-terminal NPA box, AQPs can be divided into three subfamilies: (1) glycerol-channel aquaglyceroporin (gAQP) (2) water-selective AQP (wAQP), and (3) deviated superaquaporin (sAQP) in the order of passible evolution.

All serious scientists continue to laugh about claims that transmembrane protein superfamilies automagically evolve. The energy-dependent biophysically constrained microRNA-mediated creation of the enzymes and amino acid substitutions used to create membranes links energy-dependent ecological adaptations to all biodiversity via the physiology of reproduction, not via the magic of evolution.
See also: Sender’s message: New citations to works that mention microRNA
Sent on Wednesday, 2020 February 12
LINC00167 Regulates RPE Differentiation by Targeting the miR-203a-3p/SOCS3 Axis

…reduced endogenous LINC00167 expression resulted in RPE dedifferentiation, which was typified by attenuated expression of RPE markers, reduced vascular endothelial growth factor A secretion, accumulation of mitochondrial reactive oxygen species, and interrupted phagocytic ability.

Intelligent people would ask: What causes the reduction of endogenous LINC00167 expression?
The intelligent people might examine top-down causation in the context of Lighting-up RNA aptamer transcription synchronization amplification for ultrasensitive and label-free imaging of microRNA in single cells

…sensitive detection of under-expressed miRNAs in cells and distinct differentiation of the miRNA expression variations in different cells can also be realized with this RCTsm approach in a washing-free format, making it a versatile and useful tool for imaging trace miRNAs in single cells with the great potential for early cancer diagnosis as well as biomedical research.

For a link to pathological tissue type morphology, see: Integrated analysis identifying long non-coding RNAs (lncRNAs) for competing endogenous RNAs (ceRNAs) network-regulated palatal shelf fusion in the development of mouse cleft palate

Our study demonstrated that NONMMUT004850.2/NONMMUT024276.2miR-741-3p/miR-465b-5p-Prkar1α could potentially serve as an important regulatory mechanism of palatal fusion in the development of the cleft palate.

See also: Upregulated miR-155 inhibits inflammatory response induced by C. albicans in human monocytes derived dendritic cells via targeting p65 and BCL-10

…up-regulated miR-155 acts as a negative feedback regulator in the innate immune response against C. albicans infection.

Target prediction and validation of microRNAs expressed from FSHR and aromatase genes in human ovarian granulosa cells

…we propose the involvement of hsa-miR-548ba in the regulation of follicle growth and activation via LIFR and PTEN.

For a historical perspective, see: From Fertilization to Adult Sexual Behavior

…we focus directly on molecular events themselves. Here the “environment” involved can be that within a DNA segment. We also expand the notion of “biologically based sex differences.” Although many, and perhaps most, important sex differences arise from gonadal and hormonal development, also important are sex differences which are neither gonadal nor hormonal. All these factors affect the internal workings of the individual and intervene in structuring how the social environment might or might not modify sexual behavior. This discourse calls attention to features that are central to the so-called nature-nurture discussion.

microRNA-1203 targets and silences cyclophilin D to protect human endometrial cells from oxygen and glucose deprivation-re-oxygenation

…these results show that miR-1203 targets and silences CypD to protect human endometrial cells from OGDR.

A combined microRNA and transcriptome analyses illuminates the resistance response of rice against brown planthopper

Our results provide a valuable resource to ascertain changes in BPH-induced miRNA and mRNA expression profiles and enable to comprehend plant-insect interactions and find a way for efficient insect control.

Genetically modified rice was linked to the new #coronavirus pathology from #Wuhan via effects on plant-insect interactions that have repeatedly been linked from the nutrient-dependent pheromone-controlled physiology of reproduction in bacteria to biophysically constrained viral latency and all biodiversity on Earth.
It has become almost impossible for all intelligent serious scientists to not see what neo-Darwinian theorists and Big Bang cosmologists have ignored.
See: Altered miRNA and mRNA Expression in Sika Deer Skeletal Muscle with Age

DE [Differentially expressed] unigenes and miRNA were mainly related to energy and substance metabolism, processes that are closely associate with the growth, development, and aging of skeletal muscle.

See also:
Epigenetic Alterations of Heat Shock Proteins (HSPs) in Cancer
An effect of dietary phloretin supplementation on feed intake in mice
Integration of Bioinformatic Predictions and Experimental Data to Identify circRNA-miRNA Associations.
A fungal milRNA mediates epigenetic repression of a virulence gene in Verticillium dahliae
MicroR408 regulates defense response upon wounding in sweet potato
Identification of a redox-dependent regulatory network of miRNAs and their targets in wheat

This relationship together with bioinformatics modelling of the regulatory network indicated glutathione-related redox control of miRNAs and their targets, which allows the adjustment of the metabolism to changing environmental conditions


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