Virus-driven reduction of RNA polymerase II occupancy in hosts (1)

By: James V. Kohl | Published on: March 3, 2020

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The epic failure of atheists, Communists, theorists, and other pseudoscientists to link light-activated microRNA biogenesis from biophysically constrained viral latency to healthy longevity across kingdoms can be viewed in the context of this model:
RNA decay during gammaherpesvirus infection reduces RNA polymerase II occupancy of host promoters but spares viral promoters 2/7/20

Yeast and mammals share key proteins involved in cytoplasmic mRNA decay and transcription.

…escape from transcriptional repression is linked to the localization of viral DNA within replication compartments, providing a means for these viruses to counteract decay-induced transcript loss.”

Translation: Stress-linked replication causes all virus-driven pathology.
The significance of that fact has been placed back into the context of Darwin’s “conditions of life.”
Get your copy of the game for ages 14+ that links Mendelian genetics to Darwin’s “conditions of life” and biophysically constrained coronavirus pathology across kingdoms to microRNA-mediated cancer prevention and/or effective treatment, or face ridicule.

Genotype (October 2020)

Until then, see: Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems (2018) is a mouse-to-human model of biophysically constrained coronavirus and cancer pathology via the EDAR V370A amino acid substitution.
See also: Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk

The frequency of the human-specific EDAR V370A allele appears to be uniquely elevated in North and East Asian and New World populations due to a bout of positive selection…

Natural selection for energy-dependent codon usage bias in human RNA viruses has been linked from the physiology of reproduction to biophysically constrained viral latency across kingdoms via mRNA stability.
See: Codon identity regulates mRNA stability and translation efficiency during the maternal‐to‐zygotic transition

…this code integrates multiple inputs of translation from tRNA availability and accuracy… to peptide bond formation, amino acid identity, … cellular transitions, tissues, and pathological states.

The code for biophysically constrained amino acid identity requires links from God’s Creation of energy to the creation of ATP and RNA, which have linked oxygen-dependent RNA interference to biophysically constrained viral latency since 1964.
See: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation”

The synthesis of RNA in isolated thymus nuclei is ATP dependent. Experiments are described which show that the required ATP is produced by reactions associated with glycolysis, the citric acid cycle, and a type of oxidative phosphorylation.

Summary from 3/30/16
Poster: The anti-entropic force of virucidal ultraviolet light links guanine–cytosine (G⋅C) Watson–Crick base pairing from hydrogen-atom transfer in DNA base pairs in solution to supercoiled DNA, which protects the organized genomes of all living genera from virus-driven entropy. For example, protection of DNA from permanent UV damage occurs in the context of photosynthesis and nutrient-dependent RNA-directed DNA methylation, which links RNA-mediated amino acid substitutions to DNA repair. In the context of thermodynamic cycles of protein biosynthesis and degradation, DNA repair enables the de novo creation of G protein coupled receptors (GPCRs). Olfactory receptor genes are GPCRs. The de novo creation of olfactory receptor genes links chemotaxis and phototaxis from foraging behavior to social behavior in species from microbes to humans. Foraging behavior links ecological variation to ecological adaptation in the context of this atoms to ecosystems model of biophysically constrained energy-dependent RNA-mediated protein folding chemistry. Protein folding chemistry links nutrient-dependent microRNAs from microRNA flanking sequences to energy transfer and cell type differentiation in the context of adhesion proteins, and supercoiled DNA that protects all organized genomes from virus-driven entropy.

See also: Virus-driven reduction of RNA polymerase II occupancy in hosts (2)