CDC’s ignorance: from roots to shoots (3)
(click to enlarge)
Longtime AIDS researcher Robert Redfield picked to lead CDC 3/21/18
In the early days of the AIDS crisis, Dr Redfield…[failed to learn about biophysically constrained] …active HIV replication in all stages of HIV infection.
All viral replication is energy-dependent and microRNA-mediated.
Without realizing it, the director of the CDC linked food energy-dependent pheromone-controlled fixation of amino acid substitutions from virulence in HIV-1 to less virulence in HIV-2.
See: Correlation of Antibody Responses to a Peptide Antigen gp120-C5501–512 /gp41732–744 with HIV Disease Progression 6/1/17
Partial antigenic cross-reactivity between SE and C5 is indicated by partial inhibition of NVS antibody binding using SE 15-mer peptide (median 65% inhibition), the C5501–506 6-mer peptide (79% inhibition), and binding of rheumatoid arthritis patient sera to both SE and C5 peptide sequences. The potential influence of these observations on HIV-1 pathogenesis remains to be determined.
The influence of the light-activated assembly of the microRNA-RNA-peptide nanocomplex on biophysically constrained viral latency has been detailed in more than 100,000 indexed published works that mention “microRNA .”
Expect obfuscation of facts about conserved molecular mechanisms and differences in Covid19 strains.
It’s Official: CDC Recommends Public Wear Face Masks
…Trump said he has no plans to follow the recommendation himself to wear a mask in public. “I’m choosing not to do it…
He obviously knows that the director of the CDC failed to learn enough about microRNA-mediated HERVs, despite the director’s publication(s) on HIV-1 and HIV-2.
If not for director of the CDC’s ignorance & incompetence, nutrient stress & social stress-linked differences in microRNA-mediated HIV-1 & HIV-2 would by now have been linked to differences in strains of influenza viruses coronaviruses & Covid19.
See: TWO strains of the killer coronavirus are spreading around the world – and 70% of infected patients have caught the more aggressive and contagious type, study claims 3/4/20
The coronavirus has mutated into at least two separate strains since the outbreak began in December, according to Chinese scientists.
Only atheists and biologically uninformed science idiots claim that viruses mutate without linking the mutations to disease. The atheists and idiots link the mutations to evolution.
Viruses adapt. The molecular mechanisms of energy-dependent biophysically constrained adaptations have been detailed.
See: A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2 and SARS-CoV 4/3/20
…there is currently very little understanding of the antigenicity of the virus.
Reported as: Clues to COVID-19 coronavirus’s vulnerability emerge from an antibody against SARS 4/3/20
A key finding is that the antibody’s binding site is highly similar between the two coronaviruses—differing by just four protein building blocks called amino-acids. That high degree of similarity implies that the site has an important function that would be lost if it mutated significantly.
See: Substitutions Near the Receptor Binding Site Determine Major Antigenic Change During Influenza Virus Evolution 11/22/13
Editor’s summary: Five antigenic sites in the virus surface hemagglutinin protein, which together comprise 131 amino acid positions, are thought to determine the full scope of antigenic drift of influenza A virus. Koel et al. (p. 976) show that major antigenic change can be caused by single amino acid substitutions.
The current pandemic was caused by the ignorance of biologically uninformed science idiots who did not learn the difference between a mutation and biophysically constrained energy-dependent microRNA-mediated fixation of amino acid substitutions.
…Fauci stands accused of trying to turn the United States into “a police state like China in order to stop coronavirus.
…the disregard for expert guidance being pushed by some conservative and libertarian voices goes further — aimed not simply at proving Fauci wrong but at painting him as an agent of the “deep state” that Trump has vowed to dismantle.
The Governor of Georgia did that on Friday 4/3/20 GA Governor Finally Issues Stay-At-Home Order, Says He Didn’t Know Asymptomatic People Could Be Contagious
If you let them, biologically uninformed science idiots like the Governor of Georgia will eliminate your First Amendment rights to assemble en masse, and to travel between counties and states without restriction. He will pit states against states in the context of economic and political policies that are designed by the so-called “deep state.”
For comparison to a well-orchestrated coup, two recent addition to more than100,000 other indexed publications link light-activated microRNA biogenesis from biophysically constrained viral latency in plants across kingdoms to control of all virus-driven pathology in humans.
1) MpFEW RHIZOIDS1 miRNA-Mediated Lateral Inhibition Controls Rhizoid Cell Patterning in Marchantia polymorpha 3/29/20
…the modeling and genetic data indicate that MpFRH1 miRNA mediates lateral inhibition by repressing MpRSL1 during pattern formation in the M. polymorpha epidermis.
The model of light-activated biophysical constraints on coronavirus pathology is place back into the context of neo-Darwinian pseudoscientific nonsense and Big Bang cosmology.
2) Imprinted Small RNAs Unraveled: Maternal MicroRNAs Antagonize a Paternal-Genome-Driven Gene Expression Network 4/2/20
…maternally expressed microRNAs post-transcriptionally downregulates several imprinted genes expressed from the paternal genome-an antagonistic mechanism that modulates neuronal functions and provides insights into the evolution of genomic imprinting.
All genotypes are energy-dependent and constrained by feedback loops that link angstroms to ecosystems via everything known to serious scientists.
See: Get Well in the RNAi Way-RNAi, A Billion Dollar Baby in Therapy (2016) and Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems (2018)
For comparison see: A universal trend of amino acid gain and loss in protein evolution 2/10/05
Amino acid composition of proteins varies substantially between taxa and, thus, can evolve.
Remember: Dynein is a family of cytoskeletal motor proteins that move along microtubules in cells. They convert the chemical energy stored in ATP to mechanical work.
But also remember proteins do not create themselves and that proteins do not evolve.
See also: Genotype: A Mendelian Genetics Game 4/4/20
Genotype is on schedule. We don’t know what the next 6 month will hold for our manufacturing and fulfillment timelines, but we’re doing all we can, trying to leave extra time, and our internal work is going great.
Genotypes do not evolve.
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Life: conserved ion and amino acid transporters
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0
Creating nothing but a theory
4 MIN READ
0
2 genes in 2 species (too expensive and too insignificant)
11 MIN READ
0
Quantum correlations/pseudoscience
3 MIN READ
0
Anti-entropic solar energy
5 MIN READ
0
Correctly modeling biological energy
2 MIN READ
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Questions about life’s diversity
21 MIN READ
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RNA-directed gene choice
5 MIN READ
0
Walk towards the light
< 1 MIN READ
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Is DNA-directed transcription RNA-mediated?
2 MIN READ
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What about birds?
5 MIN READ
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Reverse phosphorylation
7 MIN READ
0
RNA-mediated repurposing in microbes and adaptations in primate brains
2 MIN READ
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RNA-mediated “repurposing” is nutrient-dependent and pheromone-controlled
3 MIN READ
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RNA-mediated "repurposing" is nutrient-dependent and pheromone-controlled
3 MIN READ
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From 3-D to epigenetically-effected 4-D genome make-up
5 MIN READ
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Let there be anti-entropic light (1)
11 MIN READ
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An epigenetic trap (the prequel)
5 MIN READ
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Imagining that data historically supports evolutionary theory
7 MIN READ
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The anti-entropic force of "Nature"
2 MIN READ
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Nutritional epigenetics, exercise, and immune system integrity
4 MIN READ
0
Military combat training to fight disease (2)
3 MIN READ
0
Atoms to ecosystems is not almost a molecular ecology
3 MIN READ
0
Epigenetic effects of viruses on cellular homeostasis (2)
2 MIN READ
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RNA-mediated epigenetic modification via DNA-methylation
4 MIN READ
0
How fast can evolutionary theory be changed?
5 MIN READ
0
Biological energy and a microbiome model of a light-driven time machine
3 MIN READ
0
Quantum Superpositions: let there be light
4 MIN READ
0
Are viruses microRNAs? (2)
5 MIN READ
0
Sneaking up from behind
4 MIN READ
0
Beneficial microbes kill beneficial mutations
4 MIN READ
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Constrained evolution is ecological adaptation
5 MIN READ
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A single amino acid substitution differentiates cell types of E. coli
3 MIN READ
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Unconstrained evolutionary innovability
4 MIN READ
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Mutagenesis: Replacing facts with theories
5 MIN READ
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ISHE's human ethology group
2 MIN READ
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From Hydra to humans vs a Lakatosian research program
4 MIN READ
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Unified nutritional and molecular mechanisms
9 MIN READ
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Model organisms: the birds and the bees
3 MIN READ
0
Chemical ecology and RNA-mediated control of DNA loops
< 1 MIN READ
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Atoms to ecosystems: Evolutionary theory vs the coelacanth
6 MIN READ
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Jumping back: Science or Pseudoscience? (2)
2 MIN READ
0
Jumping back: Science or Pseudoscience?
6 MIN READ
0
Single-cell level assay of protein biosynthesis and degradation
2 MIN READ
0
Dual genomes: exposing the evolution industry
5 MIN READ
0
RNA-mediated events and "The Theory of Everything"
4 MIN READ
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RNA-mediated species specificity
2 MIN READ
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Are mutations beneficial?
4 MIN READ
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The key to science: experimental evidence
5 MIN READ
0
Ecological adaptations reported as evolution in insects and mammals
4 MIN READ
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Biologists puzzled by evolved RNAs and decaying DNA
6 MIN READ
0
More than a bag of chemicals?
2 MIN READ
0
Nothing new under the sun, except pseudoscientific nonsense
6 MIN READ
0
Making sense of quotes scattered across disciplines
2 MIN READ
0
Intelligent viruses and cancers?
10 MIN READ
0
Complex behaviors of cell types in cancer
6 MIN READ
0
De novo DNA methylation?
3 MIN READ
0
Sexual differentiation of cell types in plants
2 MIN READ
0
A model of MHC 'evolution'
2 MIN READ
0
From deep time into real time: What evolutionary processes?
10 MIN READ
0
In theory, or supported by experimental evidence?
5 MIN READ
0
Are evolutionary theorists 'nob ends'?
5 MIN READ
2
No excuses: Creation and the meaning of organismal complexity
7 MIN READ
0
Nutrient-dependent gene duplication in plants (but not animals?)
4 MIN READ
0
Behavioral ecology: please continue to believe in our fantasies
3 MIN READ
0
RNA-mediated genetic engineering (Part 3)
< 1 MIN READ
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RNA-mediated genetic engineering (Part 2)
3 MIN READ
0
RNA-mediated genetic engineering
2 MIN READ
0
Color vision refutes the evolutionary dogma of gene duplication
4 MIN READ
0
Forces of "Nature" limit dissemination of information
4 MIN READ
0
Genomic surveillance ends our world of RNA-mediated ecological adaptations
2 MIN READ
0
Different physical locations and different molecular mechanisms of health and disease
2 MIN READ
0
Metabolism, fixation, health or neurodegerative disorder
2 MIN READ
0
Physics, Chemistry, and Molecular biology (PCMb)
2 MIN READ
0
Physics denied; pseudoscientific nonsense accepted
2 MIN READ
0
Ecological variation and niche construction: 1, 2, 3
6 MIN READ
0
Stop evolutionary theorists. Kill cancers
3 MIN READ
0
De novo gene Creation sans evolution of genes via mutations
4 MIN READ
0
Seemingly futile cycles are not thermodynamically futile
3 MIN READ
0
Memory of repression and memory of behavior
2 MIN READ
0
Exploding genomes and chromosomal rearrangements via RNA-mediated events
2 MIN READ
0
Behavior (2): All responses are RNA-mediated not genetically-determined
4 MIN READ
0
Baby talk: More misrepresentations of ecological adaptations
2 MIN READ
0
Epimutations: Attacking pseudoscientific dogmas
4 MIN READ
0
Order and disorder: Ecological adaptations not mutations
6 MIN READ
0
The quantum biology of consciousness
3 MIN READ
0
Ecologically linked adapted ants and brains
2 MIN READ
0
Cell-type differentiation
2 MIN READ
0
96 fixed amino acid substitutions, not 96 genes
6 MIN READ
0
Social experiences epigenetically effect gene networks
2 MIN READ
0
Pheromone-controlled thermodynamics and cancer
2 MIN READ
0
Honeybees, food odors, and perfume
< 1 MIN READ
0