CDC’s ignorance: from roots to shoots (3)

By: James V. Kohl | Published on: April 5, 2020

Longtime AIDS researcher Robert Redfield picked to lead CDC 3/21/18

In the early days of the AIDS crisis, Dr Redfield…[failed to learn about biophysically constrained] …active HIV replication in all stages of HIV infection.

All viral replication is energy-dependent and microRNA-mediated.
Without realizing it, the director of the CDC linked food energy-dependent pheromone-controlled fixation of amino acid substitutions from virulence in HIV-1 to less virulence in HIV-2.
See: Correlation of Antibody Responses to a Peptide Antigen gp120-C5501–512/gp41732–744 with HIV Disease Progression 6/1/17

Partial antigenic cross-reactivity between SE and C5 is indicated by partial inhibition of NVS antibody binding using SE 15-mer peptide (median 65% inhibition), the C5501–506 6-mer peptide (79% inhibition), and binding of rheumatoid arthritis patient sera to both SE and C5 peptide sequences. The potential influence of these observations on HIV-1 pathogenesis remains to be determined.

The influence of the light-activated assembly of the microRNA-RNA-peptide nanocomplex on biophysically constrained viral latency has been detailed in more than 100,000 indexed published works that mention “microRNA.”

Expect obfuscation of facts about conserved molecular mechanisms and differences in Covid19 strains.
It’s Official: CDC Recommends Public Wear Face Masks

…Trump said he has no plans to follow the recommendation himself to wear a mask in public. “I’m choosing not to do it…

He obviously knows that the director of the CDC failed to learn enough about microRNA-mediated HERVs, despite the director’s publication(s) on HIV-1 and HIV-2.
If not for director of the CDC’s ignorance & incompetence, nutrient stress & social stress-linked differences in microRNA-mediated HIV-1 & HIV-2 would by now have been linked to differences in strains of influenza viruses coronaviruses & Covid19.
See: TWO strains of the killer coronavirus are spreading around the world – and 70% of infected patients have caught the more aggressive and contagious type, study claims 3/4/20

The coronavirus has mutated into at least two separate strains since the outbreak began in December, according to Chinese scientists.

Only atheists and biologically uninformed science idiots claim that viruses mutate without linking the mutations to disease. The atheists and idiots link the mutations to evolution.
Viruses adapt. The molecular mechanisms of energy-dependent biophysically constrained adaptations have been detailed.
See: A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2 and SARS-CoV 4/3/20

…there is currently very little understanding of the antigenicity of the virus.

Reported as: Clues to COVID-19 coronavirus’s vulnerability emerge from an antibody against SARS 4/3/20

A key finding is that the antibody’s binding site is highly similar between the two coronaviruses—differing by just four protein building blocks called amino-acids. That high degree of similarity implies that the site has an important function that would be lost if it mutated significantly.

See: Substitutions Near the Receptor Binding Site Determine Major Antigenic Change During Influenza Virus Evolution 11/22/13

Editor’s summary: Five antigenic sites in the virus surface hemagglutinin protein, which together comprise 131 amino acid positions, are thought to determine the full scope of antigenic drift of influenza A virus. Koel et al. (p. 976) show that major antigenic change can be caused by single amino acid substitutions.

The current pandemic was caused by the ignorance of biologically uninformed science idiots who did not learn the difference between a mutation and biophysically constrained energy-dependent microRNA-mediated fixation of amino acid substitutions.

Now that more than 100,000 publications attest to that fact, why does it seem to me that I have lost all support for my claims during the week when the President of the United States appears to have accepted them?

See: As Trump signals readiness to break with experts, his online base assails Fauci 3/26/20

…Fauci stands accused of trying to turn the United States into “a police state like China in order to stop coronavirus.

…the disregard for expert guidance being pushed by some conservative and libertarian voices goes further — aimed not simply at proving Fauci wrong but at painting him as an agent of the “deep state” that Trump has vowed to dismantle.

The Governor of Georgia did that on Friday 4/3/20 GA Governor Finally Issues Stay-At-Home Order, Says He Didn’t Know Asymptomatic People Could Be Contagious

If you let them, biologically uninformed science idiots like the Governor of Georgia will eliminate your First Amendment rights to assemble en masse, and to travel between counties and states without restriction. He will pit states against states in the context of economic and political policies that are designed by the so-called “deep state.”

For comparison to a well-orchestrated coup, two recent addition to more than100,000 other indexed publications link light-activated microRNA biogenesis from biophysically constrained viral latency in plants across kingdoms to control of all virus-driven pathology in humans.

1) MpFEW RHIZOIDS1 miRNA-Mediated Lateral Inhibition Controls Rhizoid Cell Patterning in Marchantia polymorpha 3/29/20

…the modeling and genetic data indicate that MpFRH1 miRNA mediates lateral inhibition by repressing MpRSL1 during pattern formation in the M. polymorpha epidermis.

The model of light-activated biophysical constraints on coronavirus pathology is place back into the context of neo-Darwinian pseudoscientific nonsense and Big Bang cosmology.

2) Imprinted Small RNAs Unraveled: Maternal MicroRNAs Antagonize a Paternal-Genome-Driven Gene Expression Network 4/2/20

…maternally expressed microRNAs post-transcriptionally downregulates several imprinted genes expressed from the paternal genome-an antagonistic mechanism that modulates neuronal functions and provides insights into the evolution of genomic imprinting.

All genotypes are energy-dependent and constrained by feedback loops that link angstroms to ecosystems via everything known to serious scientists.

See: Get Well in the RNAi Way-RNAi, A Billion Dollar Baby in Therapy (2016) and Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems (2018)

For comparison see: A universal trend of amino acid gain and loss in protein evolution 2/10/05

Amino acid composition of proteins varies substantially between taxa and, thus, can evolve.

Remember: Dynein is a family of cytoskeletal motor proteins that move along microtubules in cells. They convert the chemical energy stored in ATP to mechanical work.
But also remember proteins do not create themselves and that proteins do not evolve.

See also: Genotype: A Mendelian Genetics Game 4/4/20

Genotype is on schedule. We don’t know what the next 6 month will hold for our manufacturing and fulfillment timelines, but we’re doing all we can, trying to leave extra time, and our internal work is going great.

Genotypes do not evolve.

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