The microRNA-mediated future of humanity (3)
(click to enlarge)
Light-activated microRNA biogenesis has been linked from the pheromone-controlled physiology of reproduction to healthy longevity via protection from the virus-driven degradation of messenger RNA in all living genera.
On 4/21/20 that fact was misrepresented as: Coronavirus has mutated into at least 30 different strains, Chinese study finds. The report was based on this non-peer-reviewed paper Patient-derived mutations impact pathogenicity of SARS-CoV-2
We observed intrapersonal variation and 6 different mutations in the spike glycoprotein (S protein), including 2 different SNVs that led to the same missense mutation. Therefore, we provide direct evidence that the SARS-CoV-2 has acquired mutations capable of substantially changing its pathogenicity.
For comparison to their ridiculous claims about aquired mutations, see: Bacterial motility confers fitness advantage in the presence of phages 8/13/13
This study highlights the crucial role the parasites can play on the evolution of dispersal and, more specifically, that bacteriophages, which are ubiquitous, are likely to select for bacterial motility.
Natural selection for energy-dependent biophysically constrained autophagy has been linked to healthy longevity across kingdoms and to the microRNA-mediated future of humanity via a linear model of food energy-dependent pheromone-controlled autophagy.ย The energy for autophagy comes from sunlight. For comparison to random mutations and evolution, the linear model linksย sunlight from bacterial fitness to the biophysically constrained development of the retina in mice via the weekend resurrection of the bacterial flagellum.
There is no requirement for any theory in which billions of years of evolution are required because bacteria evolve over a weekendย 2/26/15
VIDEO
The weekend resurrection of what theorists refer to as an irreducibly complex functional structure, the bacterial flagellum, can be linked to the Creation of another irreducibly complex functional structure, namely the eye. Light activated microRNA biogenesis of enzyme-dependent endogenous substrates in bacteria is the only obvious link to energy-dependent retinal development and the Creation of the human eye.
See: Identification of key miRNAs and genes for mouse retinal development using a linear model 4/21/20 (with my emphasis )
MicroRNAs (miRNAs) are upstream regulators of gene expression and are involved in several biological processes.
I learned about the importance ofย light-activated energy-dependent microRNA biogenesis by asking a question after a conference presentation in 2012. The Society for Neuroscience symposium speaker (Timothy Bredy, perhaps) claimed that microRNAs regulated all gene expressionย I confirmed his claim with several other experts from the audience before attending every poster session that indicated it would be about microRNAs.
See: Functional Interplay between Small Non-Coding RNAs and RNA Modification in the Brain 6/7/18
During the past two decades it has become perfectly clear that light-activated microRNA biogenesis links energy-dependent autophagy to prevention of all virus-driven diseases via the innate immune system in bacteria, which is called CRISPR. The innate immune system in bacteria has been linked to the innate immune system of mammals by the effects of sunlight on food energy-dependent pheromone-controlled reproduction, which maintains the integrity of the major histocompatibility complex, referred to as the MHC.
See this report: Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I 4/22/20
Our findings demonstrate a role for enhanced autophagy or lysosome function in immune evasion by selective targeting of MHC-I molecules for degradation, and provide a rationale for the combination of autophagy inhibition and dual ICB therapy as a therapeutic strategy against PDAC.
Also, light-activated microRNA-mediated cancer therapy links microRNA biogenesis to protection from coronavirus pathology and cancer via the patent:
Methods and compositions for identifying a peptide having an intermolecular interaction with a target of interest 12/25/18 See also their proof of concept
See for review:
The microRNA-mediated future of humanity (1)
and
The microRNA-mediated future of humanity (2)
Also, remember this:
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2
0
Energy-dependent purifying selection / autophagy (3)
2
0
Energy-dependent purifying selection / autophagy (4)
2
0
Energy-dependent purifying selection / autophagy (5)
2
0
Energy-dependent purifying selection / autophagy
2
0
Optogenetics: Let there be virucidal light!
2
0
Theorists struggle with the concept of autophagy
2
0
Base pairs, amino acids and phenotypes
10
0
Survivors of RNA-mediated terrorism
5
0
RNA-mediated terrorism
< 1
0
Building delicious base pairs in class. It’s elementary Watson and Crick
3
0
Building delicious base pairs in class. It's elementary Watson and Crick
3
0
RNA-mediated “repurposing” is autophagy
2
0
RNA-mediated "repurposing" is autophagy
2
0
Epigenetics and autophagy vs mutations and evolution (8)
4
0
Energy-dependent maternal-to-zygotic transition
6
1
Virus-driven mutation or amino acid substitution
5
0
Epigenetics and autophagy vs mutations and evolution (7)
3
0
Epigenetics and autophagy vs mutations and evolution (4)
< 1
0
Epigenetics and autophagy vs mutations and evolution (3)
< 1
0
Epigenetics and autophagy vs mutations and evolution (2)
2
0
Polycombic ecological adaptation as a science, not a theory (2)
12
0
Polycombic ecological adaptation as a science, not a theory
3
0
80 years of causal analysis (1936 – 2016)
11
0
The natural success of RNAi and failed treatment
7
0
Pheromone-controlled autophagy
4
0
Virus-mediated hecatombic evolution
2
0
Hecatombic evolution via oncocers and oncohistones
9
0
Did evolution autophosphorylate your kinases?
5
1
Nutrient-dependent autophagy
3
0
Nutrient-dependent pheromone-controlled autophagy (2)
6
0
The last RNA-mediated theory killer (2)
7
0
Asking the right questions (2)
3
0
Nutrient-dependent pheromone-controlled autophagy
3
0
Life is energy-dependent task management
3
0
Hypothesis free pseudoscience vs facts (5)
6
0
Hypothesis free pseudoscience vs facts (4)
5
0
The last RNA-mediated theory killer
< 1
0
Hydrogen-atom energy in DNA base pairs
6
0
Light energy-dependent active motifs
6
0
Light energy-induced base pair changes (2)
4
0
Light energy-induced base pair changes (1)
6
0
Linking RNA structure to function
3
0
How did the innate immune system evolve?
4
0
Increased soil pH and nutrient availability
4
0
Energy-dependent cellular communication
3
0
Antithetical conclusions (7)
3
0
Non-random pheromone-controlled cell type differentiation
3
0
Energy-dependent natural fluorescence and bioluminescence
2
0
GC-rich neo-Darwinian train wreck
5
0
Biophotonics, glycobiology, quantized biodiversity (3)
< 1
0
Biophysically constrained cell type differentiation
3
0
From angstroms to ecosystems
7
0
Food supplement or licensed immunostimulant?
6
0
Q and A: Energy-dependent cell type differentiation
10
0
Virus-driven downsizing of the human brain
2
0
Innate immunity and multiplexing
7
0
Major transition ends use of silly theories
5
0
RNA methylation
2
0
The Mind’s Eyes (revisited)
10
0
Energy-dependent biodiversity (4)
4
0
Energy-dependent biodiversity (3)
7
0
Energy-dependent creation and entropy
4
0
RNA-mediated physics, chemistry, and molecular epigenetics (5)
6
0
RNA-mediated physics, chemistry, and molecular epigenetics (4)
5
0
RNA-mediated physics, chemistry, and molecular epigenetics (3)
5
0
RNA-mediated physics, chemistry, and molecular epigenetics (2)
7
0
Wasted Templeton Funding (3)
2
0
Millions of water molecules vs years of evolution
2
0
A bumper crop of virus-infected weeds and people
2
0
Molecular Diagnostics: What is unprotected life?
2
0
Ricki Lewis’ Time Machine (4)
8
0
Selective reporting of inferences: examples of pseudoscience
14
0
Energy dependent RNA-mediated immunity (5)
4
0
Energy dependent RNA-mediated immunity (2)
10
0
Energy-dependent RNA-mediated immunity (1)
10
0
Science vs semantics
4
0
Bacteria see the light and they adapt (2)
5
0
Soil bacteria, bulls, cows, microRNAs, and mammary glands
3
0
Hybrids: making microbes and Democrats into monkey’s uncles?
11
0
Creating gravity, nucleic acids, receptors, and supercoiled DNA (2)
9
0
Bacteria see the light and they adapt
7
0
Cancer: Evolution 2.0’s Blind Spot
13
0
Ricki Lewis’ Time Machine
5
0
Hydrogen-Atom Transfer in DNA Base Pairs (4)
4
0
Stress-induced energy-dependent DNA repair
4
0
A failed theory of cancer: two more decades of pseudoscience
5
0
Natural cooperation and Evolution 2.0
6
0
MicroRNAs vs Red Queen hypothesis
4
0
Plasma created by sunlight and RNAโmediated epigenetic heredity
2
0
Positive feedback loops and epigenetic traps
2
0
Theorists can’t understand biology
6
0
Receptor methylation controls behavior
2
0
MicroRNA-encoded behavior
7
0
The virome, microbiome, replisome and supercoiled DNA
2
0
Skip the politics; embrace the facts
5
0
Let there be anti-entropic light (2)
4
0
Is mainstream science in “Science” pseudoscience?
5
0
Mechanisms of stress: from genes to cancer
9
0
Theorists have not seen the light
4
0
A 5-10K comparison of design principles to evolution
3
0
Alternative pre-mRNA splicing and ecological adaptation
7
0
“New” quantum biology. Pirating the old
3
0
Is life the balance between quantum and classical physics?
3
0
Anti-entropic containment of energy: symbiosis 1.0
5
0
The stability of organized genomes (4)
3
0
RNA-mediated terms of virus-induced en-deer-ment
2
0
Hematopoiesis and practopoiesis
4
0
Becoming biologically informed (3)
3
0
Easy editing: Reinventing our RNA world
3
0
“New” epigenetic mechanism for lifelong learning?
3
0
Protein folding and Google page rank
2
0
Living the life that randomness created? (Sarcasm alert)
3
0
Epigenetic regulation of aging by glycine and GnRH
5
0
Pattern recognition: biogeochemical structure and function
5
0
Informing the biologically uninformed
< 1
0
Batch effect vs epigenetic effects
3
0
Bee-birthed epigenetics and primate cell types
5
0
Virus-driven cancer treatment and prevention
2
0
A special issue on nutritional epigenetics
5
0
Retinoic acid + one receptor regulate the genome
3
0
From gut bacteria to breast milk and back
5
0
Epigenetics vs the fossil record
4
0
RNA-mediated cell types and precision medicine
5
0
Misunderstanding cancer
7
0
Nutrient-dependent RNA interference (2)
4
0
Nutrient-dependent microRNAs control cell types
6
0
2 genes in 2 species (too expensive and too insignificant)
11
0
Quantum correlations/pseudoscience
3
0
Anti-entropic solar energy
5
0
Correctly modeling biological energy
2
0
RNA-directed gene choice
5
0
Epigenetics Skeptism
5
0
What about birds?
5
0
Reverse phosphorylation
7
0
RNA-mediated repurposing in microbes and adaptations in primate brains
2
0
RNA-mediated “repurposing” is nutrient-dependent and pheromone-controlled
3
0
RNA-mediated "repurposing" is nutrient-dependent and pheromone-controlled
3
0
Let there be anti-entropic light (1)
11
0
An epigenetic trap (the prequel)
5
0
Imagining that data historically supports evolutionary theory
7
0
The anti-entropic force of "Nature"
2
0
Nutritional epigenetics, exercise, and immune system integrity
4
0
Atoms to ecosystems is not almost a molecular ecology
3
0
Epigenetic effects of viruses on cellular homeostasis (2)
2
0
Biological energy and a microbiome model of a light-driven time machine
3
0
Quantum Superpositions: let there be light
4
0
Are viruses microRNAs? (2)
5
0
Sneaking up from behind
4
0
Beneficial microbes kill beneficial mutations
4
0
Constrained evolution is ecological adaptation
5
0
A single amino acid substitution differentiates cell types of E. coli
3
0
Unconstrained evolutionary innovability
4
0
Mutagenesis: Replacing facts with theories
5
0
ISHE's human ethology group
2
0
From Hydra to humans vs a Lakatosian research program
4
0
Unified nutritional and molecular mechanisms
9
0
Model organisms: the birds and the bees
3
0
Chemical ecology and RNA-mediated control of DNA loops
< 1
0
Jumping back: Science or Pseudoscience?
6
0
Single-cell level assay of protein biosynthesis and degradation
2
0
Dual genomes: exposing the evolution industry
5
0
RNA-mediated species specificity
2
0
Are mutations beneficial?
4
0
Ecological adaptations reported as evolution in insects and mammals
4
0
Biologists puzzled by evolved RNAs and decaying DNA
6
0
Nothing new under the sun, except pseudoscientific nonsense
6
0
Making sense of quotes scattered across disciplines
2
0
Intelligent viruses and cancers?
10
0
Sexual differentiation of cell types in plants
2
0
A model of MHC 'evolution'
2
0
From deep time into real time: What evolutionary processes?
10
0
Are evolutionary theorists 'nob ends'?
5
2
No excuses: Creation and the meaning of organismal complexity
7
0
Nutrient-dependent gene duplication in plants (but not animals?)
4
0
Behavioral ecology: please continue to believe in our fantasies
3
0
RNA-mediated genetic engineering (Part 2)
3
0
RNA-mediated genetic engineering
2
0
Color vision refutes the evolutionary dogma of gene duplication
4
0
Genomic surveillance ends our world of RNA-mediated ecological adaptations
2
0
Metabolism, fixation, health or neurodegerative disorder
2
0
Physics, Chemistry, and Molecular biology (PCMb)
2
0
Ecological variation and niche construction: 1, 2, 3
6
0
Stop evolutionary theorists. Kill cancers
3
0
De novo gene Creation sans evolution of genes via mutations
4
0
Seemingly futile cycles are not thermodynamically futile
3
0
Memory of repression and memory of behavior
2
0
Exploding genomes and chromosomal rearrangements via RNA-mediated events
2
0
Behavior (2): All responses are RNA-mediated not genetically-determined
4
0
Biophysically constrained beginnings of RNA and DNA
4
0
Baby talk: More misrepresentations of ecological adaptations
2
0
Epimutations: Attacking pseudoscientific dogmas
4
0
Order and disorder: Ecological adaptations not mutations
6
0
The quantum biology of consciousness
3
0
Cell-type differentiation
2
0
96 fixed amino acid substitutions, not 96 genes
6
0
Social experiences epigenetically effect gene networks
2
0
Pheromone-controlled thermodynamics and cancer
2
0
Understanding the role of mutations and evolution
4
0
Honeybees, food odors, and perfume
< 1
0
(click to enlarge)