The microRNA-mediated future of humanity (6)

By: James V. Kohl | Published on: May 2, 2020

Olfactory specificity regulates lipid metabolism through neuroendocrine signaling in Caenorhabditis elegans3/19/20

Optogenetic activation or inhibition of the responsible olfactory neural circuit promotes the loss or gain of fat storage, respectively.

To investigate the endocrine factors that mediate the communication between the olfactory neural circuit and the fat storage tissue, we focused on neuropeptides that are small sequences of amino acids secreted from neurons and crucial for long-range signal transduction in animals.

Optogenetic activation or inhibition is light-activated and microRNA-mediated via carbon fixation and RNA interference across kingdoms. RNA interference links fixation of RNA-mediated amino acid substitution to cell type differentiation in all cell type of all individuals of all species.
See our section on molecular epigenetics in: From Fertilization to Adult Sexual Behavior (1996)

Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans (Adler and Hajduk, 1994; de Bono, Zarkower, and Hodgkin, 1995; Ge, Zuo, and Manley, 1991; Green, 1991; Parkhurst and Meneely, 1994; Wilkins, 1995; Wolfner, 1988). That similar proteins perform functions in humans suggests the possibility that some human sex differences may arise from alternative splicings of otherwise identical genes.

Our claims about Caenorhabditis elegans and other species have been recapitulated, in part, and reported as: Watch that smell! Scents can regulate fat storage 4/16/20

When we found a connection with the sense of smell, we were very surprised.

See also: Olfaction Warps Visual Time Perception  3/17/17

The authors linked God’s Creation of the sense of smell in bacteria to our visual perception of energy and mass across the time-space continuum via His simultaneous Creation of the immune system.

See my review of nutritional epigenetics: Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems 4/18/18

This angstroms to ecosystems model of ecological adaptation links nutrient energy-dependent epigenetic effects on base pairs and amino acid substitutions to pheromone-controlled changes in the microRNA/messenger RNA balance and chromosomal rearrangements via the physiology of reproduction in species from microbes to humans.

On 5/1/20, this article linked God’s Creation of UV light and water to biophysically constrained viral latency and effective treatment of coronavirus pathology via the light-activated energy-dependent microRNA-mediated changes I detailed “From Angstroms to Ecosystems”

Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir  5/1/20

Reported as: Scientists uncover structural basis for SARS-CoV-2 inhibition by Remdesivir 5/1/20

The massive replication of the virus requires the rapid synthesis of its genetic RNA.

Synthesis of RNA is light-activated and ATP-dependent in the context of clearly detailed molecular mechanisms.

Watching those who failed to link quantum coherence from energy-dependent microRNA-mediated biophysically constrained viral latency to coherently organized biology via changes in angstroms to ecosystems is more fun in the context of the ridicule.
For polite ridicule, see: All About that Base (Meghan Trainor Parody) 12/10/14
Join me in ridiculing everyone who failed to answer the question What is life when it is not protected from virus driven entropy 3/30/16

But first, see: Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems (2018)

Then see: Energy as information and constrained endogenous RNA interference 2/15/17

I reiterate, see: Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir  5/1/20

Several nucleotide analog drugs, which include Remdesivir and EIDD-2801, appear to link energy-dependent differences in two hydrogen atoms to two extra hydrogen bonds and the conserved components that maintain the structural integrity of the viral RNA-dependent RNA polymerase.

God’s Creation of zinc ions probably explains the higher potency of EIDD-2801 in inhibiting SARS-CoV-2 replication. However, no experimental evidence of top-down energy-dependent changes has linked beneficial mutations to evolved biodiversity.

All intelligent scientists should consider joining those who are Combating Evolution to Fight Disease (3/7/14) because important gaps have been filled by the molecular understanding of the energy-dependent Genesis of microRNA-mediated variation, which constrains the ability to ecologically adapt.

I am amazed by all those who continue to complain about any others who have caused the coronavirus panic, because most people have contributed to it. When President Donald J. Trump asked about injecting people with light, it was an attempt to convey the same message Richard Feynman conveyed when he linked the theories of physicists to examples of human idiocy because of their different measurements for energy.

For more forceful ridicule, see: Richard Feynman on units of energy

The food we ingest and the pheromones we produce keep viruses in check until nutrient stress and/or social stress take their toll on our innate immune system.

Stress causes new viruses to emerge. See:  Koel et al. (p. 976) show that major antigenic change can be caused by single amino acid substitutions 11/22/13 and A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmission 2/3/07

For the link from quantum coherence to biophysically constrained viral latency and coherently organized biology, see: Modern Approaches to Exact Diagonalization and Selected Configuration Interaction with the Adaptive Sampling CI Method  3/11/20

President Donald J. Trump’s  scientific advisor, KB Whaley linked God’s Creation of subatomic particles from a simulation of 34 electrons in 152 orbitals to exact diagonalization and selected configuration interaction, which biophysically constrains coherently organized biology.

See also:  News Feature: To counter the pandemic, clinicians bank on repurposed drugs 4/29/20

God’s UV light-activated Creation of one enzyme has been linked to effective treatment of all coronaviruses with remdesivar and there is no need for the development of any more vaccines.

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