The microRNA-mediated future of humanity (6)
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Olfactory specificity regulates lipid metabolism through neuroendocrine signaling in Caenorhabditis elegans 3/19/20
Optogenetic activation or inhibition of the responsible olfactory neural circuit promotes the loss or gain of fat storage, respectively.
To investigate the endocrine factors that mediate the communication between the olfactory neural circuit and the fat storage tissue, we focused on neuropeptides that are small sequences of amino acids secreted from neurons and crucial for long-range signal transduction in animals.
Optogenetic activation or inhibition is light-activated and microRNA-mediated via carbon fixation and RNA interference across kingdoms. RNA interference links fixation of RNA-mediated amino acid substitution to cell type differentiation in all cell type of all individuals of all species.
See our section on molecular epigenetics in: From Fertilization to Adult Sexual Behavior (1996)
Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans (Adler and Hajduk, 1994 ; de Bono, Zarkower, and Hodgkin, 1995 ; Ge, Zuo, and Manley, 1991 ; Green, 1991 ; Parkhurst and Meneely, 1994 ; Wilkins, 1995 ; Wolfner, 1988 ). That similar proteins perform functions in humans suggests the possibility that some human sex differences may arise from alternative splicings of otherwise identical genes.
Our claims about Caenorhabditis elegans and other species have been recapitulated, in part, and reported as: Watch that smell! Scents can regulate fat storage 4/16/20
When we found a connection with the sense of smell, we were very surprised.
See also: Olfaction Warps Visual Time Perception  3/17/17
The authors linked God’s Creation of the sense of smell in bacteria to our visual perception of energy and mass across the time-space continuum via His simultaneous Creation of the immune system.
See my review of nutritional epigenetics: Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems 4/18/18
This angstroms to ecosystems model of ecological adaptation links nutrient energy-dependent epigenetic effects on base pairs and amino acid substitutions to pheromone-controlled changes in the microRNA/messenger RNA balance and chromosomal rearrangements via the physiology of reproduction in species from microbes to humans.
On 5/1/20, this article linked God’s Creation of UV light and water to biophysically constrained viral latency and effective treatment of coronavirus pathology via the light-activated energy-dependent microRNA-mediated changes I detailed “From Angstroms to Ecosystems”
Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir 5/1/20
Reported as: Scientists uncover structural basis for SARS-CoV-2 inhibition by Remdesivir 5/1/20
The massive replication of the virus requires the rapid synthesis of its genetic RNA.
Synthesis of RNA is light-activated and ATP-dependent in the context of clearly detailed molecular mechanisms.
Watching those who failed to link quantum coherence from energy-dependent microRNA-mediated biophysically constrained viral latency to coherently organized biology via changes in angstroms to ecosystems is more fun in the context of the ridicule.
For polite ridicule, see: All About that Base (Meghan Trainor Parody) 12/10/14
Join me in ridiculing everyone who failed to answer the question What is life when it is not protected from virus driven entropy 3/30/16
But first, see: Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems (2018)
Then see: Energy as information and constrained endogenous RNA interference 2/15/17
I reiterate, see: Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir 5/1/20
Several nucleotide analog drugs, which include Remdesivir and EIDD-2801, appear to link energy-dependent differences in two hydrogen atoms to two extra hydrogen bonds and the conserved components that maintain the structural integrity of the viral RNA-dependent RNA polymerase.
God’s Creation of zinc ions probably explains the higher potency of EIDD-2801 in inhibiting SARS-CoV-2 replication. However, no experimental evidence of top-down energy-dependent changes has linked beneficial mutations to evolved biodiversity.
All intelligent scientists should consider joining those who are Combating Evolution to Fight Disease (3/7/14) because important gaps have been filled by the molecular understanding of the energy-dependent Genesis of microRNA-mediated variation, which constrains the ability to ecologically adapt.
I am amazed by all those who continue to complain about any others who have caused the coronavirus panic, because most people have contributed to it. When President Donald J. Trump asked about injecting people with light, it was an attempt to convey the same message Richard Feynman conveyed when he linked the theories of physicists to examples of human idiocy because of their different measurements for energy.
For more forceful ridicule, see: Richard Feynman on units of energy
VIDEO
The food we ingest and the pheromones we produce keep viruses in check until nutrient stress and/or social stress take their toll on our innate immune system.
Stress causes new viruses to emerge. See:Â Koel et al. (p. 976) show that major antigenic change can be caused by single amino acid substitutions 11/22/13 and A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmission 2/3/07
For the link from quantum coherence to biophysically constrained viral latency and coherently organized biology, see: Modern Approaches to Exact Diagonalization and Selected Configuration Interaction with the Adaptive Sampling CI Method 3/11/20
President Donald J. Trump’s scientific advisor, KB Whaley linked God’s Creation of subatomic particles from a simulation of 34 electrons in 152 orbitals to exact diagonalization and selected configuration interaction, which biophysically constrains coherently organized biology.
See also: Â News Feature: To counter the pandemic, clinicians bank on repurposed drugs 4/29/20
God’s UV light-activated Creation of one enzyme has been linked to effective treatment of all coronaviruses with remdesivar and there is no need for the development of any more vaccines.
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Light ‘drives’ adaptation; nothing ‘drives’ evolution (3)
< 1 MIN READ
0
Polycombic ecological adaptation as a science, not a theory (2)
12 MIN READ
0
Polycombic ecological adaptation as a science, not a theory
3 MIN READ
0
Attacking Young Earth Creationists
5 MIN READ
0
80 years of causal analysis (1936 – 2016)
11 MIN READ
0
The natural success of RNAi and failed treatment
7 MIN READ
0
Hecatombic evolution via oncocers and oncohistones
9 MIN READ
0
Nutrient-dependent autophagy
3 MIN READ
0
Hypothesis free pseudoscience vs facts (5)
6 MIN READ
0
Hypothesis free pseudoscience vs facts (4)
5 MIN READ
0
Hypothesis free pseudoscience vs facts (3)
3 MIN READ
0
Hypothesis free pseudoscience vs facts (2)
5 MIN READ
0
Chromatin: The structure of DNA
6 MIN READ
0
The Aquatic Ape / Waterside Ape divergence
6 MIN READ
0
Light energy-induced base pair changes (2)
4 MIN READ
0
Light energy-induced base pair changes (1)
6 MIN READ
0
Linking RNA structure to function
3 MIN READ
0
How did the innate immune system evolve?
4 MIN READ
0
The Aquatic Ape: New evidence?
4 MIN READ
0
Plant microRNAs slow virus-driven aging
3 MIN READ
0
Lawless evolution: No physics
4 MIN READ
0
Conserved biophotonic emissions
7 MIN READ
2
Antithetical conclusions (6)
3 MIN READ
0
Antithetical conclusions (4)
3 MIN READ
0
Anthetical conclusions (2)
5 MIN READ
0
Anthetical conclusions
3 MIN READ
0
Non-random pheromone-controlled cell type differentiation
3 MIN READ
0
Pseudoscientists ignore what serious scientists prove
6 MIN READ
0
GC-rich neo-Darwinian train wreck
5 MIN READ
0
Biophysically constrained cell type differentiation
3 MIN READ
0
From angstroms to ecosystems
7 MIN READ
0
Food supplement or licensed immunostimulant?
6 MIN READ
0
The Origin of Information (2)
6 MIN READ
0
Light ‘drives’ adaptation; nothing ‘drives’ evolution
6 MIN READ
0
Invisible dark matter
< 1 MIN READ
0
Funding the Human Genome Project-Write
2 MIN READ
0
Virus-driven downsizing of the human brain (2)
< 1 MIN READ
0
MicroRNAs and sexual orientation
8 MIN READ
0
RNA methylation (2)
7 MIN READ
0
Masters of deception about nature (2)
7 MIN READ
0
Energy-dependent RNA methylation (9)
2 MIN READ
0
Energy-dependent RNA methylation (8)
4 MIN READ
0
Energy-dependent RNA methylation (7)
7 MIN READ
0
Energy-dependent RNA methylation (6)
9 MIN READ
0
Energy-dependent RNA methylation (4)
5 MIN READ
0
War Games: False Flag Terrorism
5 MIN READ
0
The tipping point? 50, 000 publications (2)
2 MIN READ
0
Neo-Darwinism failed in 1995
3 MIN READ
0
Countdown to Genetics and Genomics
< 1 MIN READ
0
Magic, Miracle, or Molecular Mechanism (2)
8 MIN READ
0
Energy-dependent creation and entropy
4 MIN READ
0
RNA-mediated physics, chemistry, and molecular epigenetics (3)
5 MIN READ
0
RNA-mediated physics, chemistry, and molecular epigenetics
9 MIN READ
0
RNA splicing, genetic variation, and disease
2 MIN READ
0
Wasted Templeton Funding (3)
2 MIN READ
0
Molecular Diagnostics: What is unprotected life (4)
2 MIN READ
0
Molecular Diagnostics: What is unprotected life? (2)
7 MIN READ
0
Half truths support theories without facts
4 MIN READ
0
Energy dependent RNA-mediated immunity (2)
10 MIN READ
0
From angstroms to ecosystems and entropy
2 MIN READ
0
Effects on invertebrate GnRH and affects on primate behavior
6 MIN READ
0
Hybrids: making microbes and Democrats into monkey’s uncles?
11 MIN READ
0
Creating gravity, nucleic acids, receptors, and supercoiled DNA
2 MIN READ
0
Bacteria see the light and they adapt
7 MIN READ
0
The Light and Darkness of “Evolution 2.0”
11 MIN READ
0
Organic Compounds and the Miracle of Smell and Taste
7 MIN READ
0
Ricki Lewis’ Time Machine (2)
6 MIN READ
0
Virus-perturbed alternative splicings
3 MIN READ
0
Juvenile hormone links atoms to ecosystems
3 MIN READ
0
Genes, orchid odors, and pheromones from blonds
5 MIN READ
0
MicroRNA-mediated RNA epigenetics
2 MIN READ
0
Finding peace and π in the light of H bond energy
5 MIN READ
0
Epigenetic (re)programming of behavior (3)
5 MIN READ
0
Assumptions prove ignorance
5 MIN READ
0
RNA-mediated theory killers (6) (7) (8) (9) (10)
5 MIN READ
0
Manufacturing fossil “evidence”
4 MIN READ
0
A two-faced protein enables RNA-mediated DNA repair (3)
8 MIN READ
0
Neo-Darwinism vs the neocortex
4 MIN READ
0
Life and death predicted by DNA methylation
3 MIN READ
0
Receptor methylation controls behavior
2 MIN READ
0
Conserved molecular mechanisms
< 1 MIN READ
0
eQTLs and ecological adaptation
< 1 MIN READ
0
Mystery machine vs medical intelligence
2 MIN READ
0
Microbes to humans 2015 Nobel Prize
2 MIN READ
0
Pathology: Eating and breathing viruses
2 MIN READ
0
Nucleic acids: Stability of DNA/RNA
2 MIN READ
0
A “new” code enables ecological adaptation
4 MIN READ
0
Information and communication (2)
6 MIN READ
0
Olfaction & the octopus and human genomes
3 MIN READ
0
Protosuns, prebiotic molecules, proteins, and people
4 MIN READ
0
Is the best Chinese research from China?
3 MIN READ
0
Viruses, amino acids, and somatic cell types (3)
9 MIN READ
0
Viruses, amino acids, and somatic cell types
4 MIN READ
0
MicroRNA controlled growth and brain development
7 MIN READ
0
MicroRNA – controlled ecological adaptations
5 MIN READ
0
microRNAs and memory: Why trust a theory?
2 MIN READ
0
Creating and maintaining the human virome
2 MIN READ
0
Ignoring top-down causation
2 MIN READ
0
Unknown mechanisms and conclusions
2 MIN READ
0
Five years of Ferguson
2 MIN READ
0
A special issue on nutritional epigenetics
5 MIN READ
0
Protein isoforms do not evolve
3 MIN READ
0
MicroRNAs and the exposome
5 MIN READ
0
RNA-mediated silencing of a chromosome
3 MIN READ
0
RNA-mediated cell types and precision medicine
5 MIN READ
0
DNA Methylation and organized genomes
7 MIN READ
0
Misunderstanding cancer
7 MIN READ
0
Amino acid-dependent cell type differentiation
8 MIN READ
0
Mutisensory integration: watching the paradigm shift
12 MIN READ
0
Nutrient-dependent microRNAs control cell types
6 MIN READ
0
Methylation maintains cell type differences
3 MIN READ
0
Viruses and ecologically adapted animals
2 MIN READ
0
2 genes in 2 species (too expensive and too insignificant)
11 MIN READ
0
Quantum correlations/pseudoscience
3 MIN READ
0
Anti-entropic solar energy
5 MIN READ
0
Mimicking claims and ignoring facts
4 MIN READ
0
RNA-directed gene choice
5 MIN READ
0
Epigenetics Skeptism
5 MIN READ
0
What about birds?
5 MIN READ
0
Rejecting what is known about viral microRNAs and nutrient-dependent microRNAs
2 MIN READ
0
Let there be anti-entropic light (1)
11 MIN READ
0
An epigenetic trap (the prequel)
5 MIN READ
0
What if Darwin was not still dead?
2 MIN READ
0
Military combat training to fight disease (2)
3 MIN READ
0
From Hydra to humans vs a Lakatosian research program
4 MIN READ
0
Unified nutritional and molecular mechanisms
9 MIN READ
0
The future of physics predicts no future for evolutionary theory
3 MIN READ
0
Chemical ecology and RNA-mediated control of DNA loops
< 1 MIN READ
0
Jumping back: Science or Pseudoscience? (2)
2 MIN READ
0
Extensive molecular evidence vs ridiculous theories
2 MIN READ
0
Dual genomes: exposing the evolution industry
5 MIN READ
0
Meaningful dialogue, anonymous fools and idiot minions
4 MIN READ
0
Epigenetic pharmacology and RNA-mediated transciptional landscapes
3 MIN READ
0
RNA-mediated events and "The Theory of Everything"
4 MIN READ
0
Sackler Colloquium: Effects or AFFECTS on Behavior
2 MIN READ
0
More than a bag of chemicals?
2 MIN READ
0
Are evolutionary theorists 'nob ends'?
5 MIN READ
2
No understanding of biodiversity
2 MIN READ
0
Systems biology and memory disorders
3 MIN READ
0
RNA-mediated cell type differentiation and behavior
3 MIN READ
0
RNA-directed DNA methylation and RNA-mediated events
5 MIN READ
1
microRNAs differentiate neuronal cell types
3 MIN READ
0
Darwinian theories vs Darwin's facts
2 MIN READ
0
The wrong picture of our evolution
4 MIN READ
0
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