pH-dependent viral latency (2)

By: James V. Kohl | Published on: May 24, 2020

New vaccines protect against COVID-19 in non-human primates, study finds 5/20/20

See for comparison: Vaccines do not control pandemics (1) 5/15/20

I reiterate: Emergence of Human G2P[4] Rotaviruses in the Post-vaccination Era in South Korea: Footprints of Multiple Interspecies Re-assortment Events 4/18/18

Amino acid substitutions at these positions were found to be associated with an inability to serotype a strain and are responsible for antigenic changes. Recently, amino acid substitutions in the three main antigenic regions, especially at positions 96 and 213 were postulated to be associated with the emergence of rotavirus G2 in Korea during 2010–2015.

Scientific Creationists from South Korea have since detailed the molecular mechanisms that link biophysically constrained viral latency to healthy longevity via light-activated microRNA biogenesis and fixation of  RNA-mediated amino acid substitutions.
See for review: A Quick HYL1-Dependent Reactivation of MicroRNA Production Is Required for a Proper Developmental Response after Extended Periods of Light Deprivation 7/18/18

…plants alter microRNA (miRNA) biogenesis in response to light transition.

A Mechanism for microRNA Arm Switching Regulated by Uridylation

The mechanism links biophysically constrained viral latency to prevention of the activation of the virus-driven death gene that causes glioblastoma via RNA uridylation.
See also: The Role of 3′ End Uridylation in RNA Metabolism and Cellular Physiology (This article is part of the theme issue ‘5’ and 3′ modifications controlling RNA degradation’.)

U6 snRNA is a small RNA essential for pre-mRNA splicing. It is transcribed by RNA polymerase III.

Food energy-dependent pheromone-controlled alternative splicings of pre-mRNAs were linked to sympatric speciation across kingdoms via constraints on amino acid substitutions in small intranuclear proteins. See our section on molecular epigenetics section from this 1996 Hormones and Behavior review:
See: From Fertilization to Adult Sexual Behavior

Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans (Adler and Hajduk, 1994; de Bono, Zarkower, and Hodgkin, 1995; Ge, Zuo, and Manley, 1991; Green, 1991; Parkhurst and Meneely, 1994; Wilkins, 1995; Wolfner, 1988). That similar proteins perform functions in humans suggests the possibility that some human sex differences may arise from alternative splicings of otherwise identical genes.

The link from sex differences to biophysically constrained fixation of pH-dependent RNA-mediated amino acid substitutions became clearer with publication of A Two-Amino Acid Change in the Hemagglutinin of the 1918 Influenza Virus Abolishes Transmission (2007)
Two amino acids cause a switch in receptor binding preference from the human to the avian that resulted in changes in lethality and replication efficiency. The food energy-dependent pheromone-controlled two-amino acid change is the link to the end of the coronavirus COVID19 panic via the same light-activated energy-dependent microRNA-mediated molecular mechanisms.
Ask neo-Darwinian theorists and other atheists intelligent questions to learn “Why have microRNA biomarkers not been translated from bench to clinic?” Then, follow the money to the patent for naturally occurring light-activated RNA interference!
See: Get Well in the RNAi Way-RNAi, A Billion Dollar Baby in Therapy

RNAi has targeted exogenous genes in models of viral infection…

RNA does not create itself from supercoiled DNA except in gene-centric theories. In those ridiculous theories, food energy-dependent pheromone-controlled RNA interference (RNAi) is rarely considered.
See for comparison: Structural diversity of supercoiled DNA
Remember the claim from this parody:
“Every angstrom is dynamic from the 5 prime to the three”

In the context of The Role of 3′ End Uridylation in RNA Metabolism and Cellular Physiology, the TUT4/7 and 3 prime levels are upregulated, whereas the 5 prime level is reduced.
Thank God, manipulation of the strand ratio is sufficient to impair glioblastoma cell proliferation and prevent a devastating form of rapidly growing and deadly brain cancer.
That fact links the patent for the microRNA-mediated cure of all cancers to the cure for all virus-driven pathology by what is known about the nutrient-dependent pheromone-controlled functional structure of supercoiled DNA across kingdoms from microbes to humans.
See: Methods and compositions for identifying a peptide having an intermolecular interaction with a target of interest 12/25/18 and Proof of concept
See also [Pheromonal regulation of genetic processes: research on the house mouse (Mus musculus L.)] (1994)

A study of the influence of pheromone stressor(s) on proliferating germ and somatic cells was performed on laboratory lines of house mouse in the context of the physiological hypothesis of mutation process, proposed by M.E. Lobashev in 1947. Data from experiments are presented, and results obtained during last 10-15 years are discussed. The adaptive role of cytogenetic and other observed pheromonal effects is considered. The possible existence of interorganism systems of genetic regulation is discussed, the search for and study of which may help in more complete understanding of the regularities of functioning of genetic material.

The metabolism of food to species-specific pheromones, which biophysically constrain genetic processes, has always been the key to viral latency.
Past 5,000 years prolific for changes to human genome 11/28/12

The findings confirm their earlier work suggesting that the majority of variants, including potentially harmful ones, were picked up during the past 5,000–10,000 years.

Only atheists and biologically uninformed theorists deny the facts that Scientific Creationists have linked to the prevention of all diseases since the dawn of Creation.

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