Coherently organized healthy longevity (4)

By: James V. Kohl | Published on: September 25, 2020

See first: Coherently organized healthy longevity (3)

“Perfect Pairing” prevents cancer and all other forms of virus-driven pathology.

Biologically uninformed science idiots have placed everything known to serious scientists about biophysically constrained “perfect pairing,”microRNA-mediated viral latency, and healthy longevity into the context of computational biology and chemistry via theoretical pairing. See their ridiculous claim in Computational prediction of miRNA/mRNA duplexomes at the whole human genome scale reveals functional subnetworks of interacting genes with embedded miRNA annealing motifs

…a very large gene network is fully independent of any miRNA action, which supports the paradigm of “layers” of genes that are selected and built through evolution over hundreds of millions of years, with their own network regulatory modes.

The idea that genes “…are selected and built through evolution over hundreds of millions of years…” flies in the face of all intelligent serious scientists who have linked the claims of Thomas Hunt Morgan (1910) from food energy-dependent pheromone-controlled genetic processes and chromosomal rearrangements in flies, to all extant biodiversity via the physiology of reproduction and biophysically constrained viral latency in all species.
See for instance: Identification and characteristics of microRNAs from Bombyx mori 5/28/08 could have been linked at anytime during the past decade to the facts about “Energy as information and constrained endogenous RNA interference”

Maximum obfuscation of facts about biophysically constrained healthy longevity were presented yesterday in this preprint: Functional genomic screens identify human host factors for SARS-CoV-2 and common cold coronaviruses
See my comments:
After he mentioned his most recent publication, I responded with this query to @Doctorbou before he blocked me. @QUIGEN and @ABCAM appear to be distancing themselves from any pseudoscientific nonsense about Coronaviridae that does not link God’s Creation of UV light & water to viral latency across kingdoms via oxidative phosphorylation an… “…identification of the phosphatidylinositol PIK3C3 kinase complex as a potent therapeutic target for SARS-CoV-2…” is a neo-Darwinian evolutionary theory killer. /1 @Synthego team members appear to be stone-walling me after this preprint linked what is known about biophysically constrained protein-folding chemistry to virus-driven endoplasmic reticulum stress, which may be the source of all str…

Endoplasmic Reticulum Stress in Disease Pathogenesis 5/14/13

The endoplasmic reticulum (ER) is the site of synthesis and folding of membrane and secretory proteins, which, collectively, represent a large fraction of the total protein output of a mammalian cell. Therefore, the protein flux through the ER must be carefully monitored for abnormalities, including the buildup of misfolded proteins. Mammalian cells have evolved an intricate set of signaling pathways from the ER to the cytosol and nucleus, to allow the cell to respond to the presence of misfolded proteins within the ER. These pathways, known collectively as the unfolded protein response, are important for normal cellular homeostasis and organismal development and may also play key roles in the pathogenesis of many diseases. This review provides background information on the unfolded protein response and discusses a selection of diseases whose pathogenesis involves ER stress.

God’s Creation of UV light and water have been linked from oxidative phosphorylation to epigenetic effects on hormones that affect behavior and sympatric speciation.
See: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation”

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

Biologically uninformed science idiots who continue base their claims on neo-Darwinian pseudoscientific nonsense and Big Bang cosmology may continue to pit themselves against the facts because doing anything else is proof of human idiocy.
See for example: UV light, H2O, and epigenetic effects… (1)

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