Optoribogenetic-driven sympatric speciation (1)
(click to enlarge)
For presentation during session: Polycomb and chromatin remodeling
Historical perspective:
Yet another kind of epigenetic imprinting occurs in species as diverse as yeast, Drosophila, mice, and humans and is based upon small DNA-binding proteins called “chromo domain” proteins, e.g., polycomb. These proteins affect chromatin structure, often in telomeric regions, and thereby affect transcription and silencing of various genes… Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans…. 1
MicroRNA is the term now used for pre-mRNA and there are nearly 109,000 indexed publications that mention microRNAs.The ultraviolet (UV) light-activated weekend resurrection of the bacterial flagellum 2 presciently established that energy-dependent biophysically constrained cell type differentiation occurs across kingdoms in the context of the physiology of pheromone-regulated microRNA-mediated genetic processes. Facts about the energy-dependent fixation of two amino acid substitutions in the organized genome of Psueudomonas fluourescens have since been placed into the context of the newly coined term optoribogenetics.
Initial claims about an evolutionary pathway linked to the weekend resurrection of the bacterial flagellum led to a claim that “… natural selection can rapidly rewire regulatory networks in very few, repeatable mutational steps. Both steps linked energy-dependent oxidative phosphorylation to microRNA-mediated fixation of amino acid substitutions and survival of the species.
Step 1 increased intracellular levels of phosphorylated gene, ntrC, which alters an amino acid within the DNA binding domain. Step 2 redirected NtrC away from nitrogen uptake and toward its novel function as a flagellar regulator.
NtrB and NtrC make up a two-component system: Under nitrogen limitation, NtrB phosphorylates NtrC, which activates transcription of genes required for nitrogen uptake and metabolism.
Claims about a two-step evolutionary pathway make no sense in the context of what is known about optoribogenetics and microRNA-mediated cause and effect.
For instance, a two component system is unlikely to evolve in the context of UV light and water-dependent oxidative phosphorylation and RNA-mediated gene activation or microRNA-mediated silencing.3 For comparison, Bazzini et al., (2016) linked natural selection for light-activated carbon fixation and food energy-dependent pheromone-regulated genetic processes of codon optimality to4 energy-dependent microRNA-mediated polycombic ecological adaptations which are manifested in the supercoiled DNA of mammals.5
Chromosomal inheritance links the ecological adaptations from morphological phenotypes to healthy longevity via behavioral phenotypes and transgenerational epigenetic inheritance across kingdoms via microRNA-mediated biophysically constrained viral latency.6
Optoribogenetic control of regulatory RNA molecules7 that sexually differentiate the cell types of individuals and species is the obvious link from alternative splicings of otherwise identical genes to microRNA-mediated energy-dependent fixation of amino acid substitutions and ecological adaptations.
See also: A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmission.8 The link from two amino acid substitutions to the weekend resurrection of the bacterial flagellum and the end of transmission of the 1918 influenza can be viewed in the context of what was known about energy-dependent pheromone-regulated genetic processes of pheromone-controlled RNA-mediated cell type differentiation in 1996.1
Simply put, food energy and pheromone-controlled reproduction are required for survival of species from microbes to humans whether the term microRNA or pre-mRNA is used.
References
- Diamond, M.; Binstock, T.; Kohl, J. V., From Fertilization to Adult Sexual Behavior. Horm Behav 1996, 30 (4), 333-53.
- Taylor, T. B.; Mulley, G.; McGuffin, L. J.; Johnson, L. J.; Brockhurst, M. A.; Arseneault, T.; Silby, M. W.; Jackson, R. W., Evolutionary rewiring of bacterial regulatory networks. Microb Cell 2015, 2 (7), 256-258.
- McEwen, B. S.; Allfrey, V. G.; Mirsky, A. E., Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation”. Biochim Biophys Acta 1964, 91, 23-8.
- Bazzini, A. A.; Del Viso, F.; Moreno-Mateos, M. A.; Johnstone, T. G.; Vejnar, C. E.; Qin, Y.; Yao, J.; Khokha, M. K.; Giraldez, A. J., Codon identity regulates mRNA stability and translation efficiency during the maternal-to-zygotic transition. EMBO J 2016.
- Irobalieva, R. N.; Fogg, J. M.; Catanese, D. J.; Sutthibutpong, T.; Chen, M.; Barker, A. K.; Ludtke, S. J.; Harris, S. A.; Schmid, M. F.; Chiu, W.; Zechiedrich, L., Structural diversity of supercoiled DNA. Nat Commun 2015, 6.
- Barbu, M. G.; Condrat, C. E.; Thompson, D. C.; Bugnar, O. L.; Cretoiu, D.; Toader, O. D.; Suciu, N.; Voinea, S. C., MicroRNA Involvement in Signaling Pathways During Viral Infection. Frontiers in Cell and Developmental Biology 2020, 8 (143).
- Pilsl, S.; Morgan, C.; Choukeife, M.; Möglich, A.; Mayer, G., Optoribogenetic control of regulatory RNA molecules. Nature Communications 2020, 11 (1), 4825.
- Tumpey, T. M.; Maines, T. R.; Van Hoeven, N.; Glaser, L.; Solorzano, A.; Pappas, C.; Cox, N. J.; Swayne, D. E.; Palese, P.; Katz, J. M.; Garcia-Sastre, A., A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmission. Science 2007, 315 (5812), 655-9.
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How did the innate immune system evolve?
4 MIN READ
0
Plant microRNAs slow virus-driven aging
3 MIN READ
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Increased soil pH and nutrient availability
4 MIN READ
0
Antithetical conclusions (5)
4 MIN READ
0
Antithetical conclusions (4)
3 MIN READ
0
Anthetical conclusions (2)
5 MIN READ
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RNAi: From magic bullet to billion dollar baby
4 MIN READ
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Energy-dependent natural fluorescence and bioluminescence
2 MIN READ
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GC-rich neo-Darwinian train wreck
5 MIN READ
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Food supplement or licensed immunostimulant?
6 MIN READ
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The end of neo-Darwinism
5 MIN READ
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Invisible dark matter
< 1 MIN READ
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Virus-driven downsizing of the human brain
2 MIN READ
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Innate immunity and multiplexing
7 MIN READ
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RNA methylation
2 MIN READ
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Masters of deception about nature (2)
7 MIN READ
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Masters of deception about nature
8 MIN READ
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Energy-dependent RNA methylation (7)
7 MIN READ
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Energy-dependent RNA methylation (5)
3 MIN READ
0
Energy-dependent RNA methylation (2)
5 MIN READ
0
Energy-dependent RNA methylation (1)
6 MIN READ
0
War Games: False Flag Terrorism
5 MIN READ
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Countdown to Genetics and Genomics
< 1 MIN READ
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Magic, Miracle, or Molecular Mechanism (2)
8 MIN READ
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RNA-mediated physics, chemistry, and molecular epigenetics (4)
5 MIN READ
0
RNA-mediated physics, chemistry, and molecular epigenetics (2)
7 MIN READ
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Molecular Diagnostics: What is unprotected life? (2)
7 MIN READ
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Molecular Diagnostics: What is unprotected life?
2 MIN READ
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Half truths support theories without facts
4 MIN READ
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Confusing effects and affects of visual input
2 MIN READ
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Selective reporting of inferences: examples of pseudoscience
14 MIN READ
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Ignore the evidence: Rachel Feltman
5 MIN READ
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Energy dependent RNA-mediated immunity (6)
5 MIN READ
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Energy dependent RNA-mediated immunity (3)
8 MIN READ
0
Energy-dependent RNA-mediated immunity (1)
10 MIN READ
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Science vs semantics
4 MIN READ
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Bringing RNA back to epigenetics (20 years later)
11 MIN READ
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Effects on invertebrate GnRH and affects on primate behavior
6 MIN READ
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Hybrids: making microbes and Democrats into monkey’s uncles?
11 MIN READ
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Cancer: Evolution 2.0’s Blind Spot
13 MIN READ
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Virus-perturbed alternative splicings
3 MIN READ
0
Hydrogen-atom transfer in DNA base pairs (5)
10 MIN READ
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The radical pair mechanism of ecological speciation
3 MIN READ
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Origin and evolution of the genetic code
2 MIN READ
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Center stage RNA-mediated events (since 1996)
3 MIN READ
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Juvenile hormone links atoms to ecosystems
3 MIN READ
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MicroRNA-mediated RNA epigenetics
2 MIN READ
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RNA methylation, RNA-directed DNA methylation, learning and memory
3 MIN READ
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Perry Marshall: too much information for atheist PZ Myers
3 MIN READ
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NORAD: air defense and defense against genomic entropy
7 MIN READ
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Life history transitions and RNA-mediated survial
2 MIN READ
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Did Dobzhansky see the UV light of creation?
10 MIN READ
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Researchers rename, reshuffle, and reveal their ignorance
3 MIN READ
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RNA-mediated theory killers (3)
7 MIN READ
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A two-faced protein enables RNA-mediated DNA repair (4)
6 MIN READ
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Sulfated steroids and RNA-mediated identity codes
< 1 MIN READ
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Neo-Darwinism vs the neocortex
4 MIN READ
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Stress-perturbed mitochondrial dysfunction (2)
5 MIN READ
0
Behavioral Immune System model
4 MIN READ
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Theorists can’t understand biology
6 MIN READ
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Receptor methylation controls behavior
2 MIN READ
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Virus, transposon and plasmid evolution
< 1 MIN READ
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eQTLs and ecological adaptation
< 1 MIN READ
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RNA central and RNA-mediated.com
6 MIN READ
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The virome, microbiome, replisome and supercoiled DNA
2 MIN READ
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Human pheromone deniers: What’s next?
5 MIN READ
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700 million years of evolution?
5 MIN READ
0
Mystery machine vs medical intelligence
2 MIN READ
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Epigenetic inheritance of stress-perturbed protein folding
2 MIN READ
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Xist-ing on planet Earth
2 MIN READ
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Preventing genomic entropy
4 MIN READ
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Supercoiled DNA constrains virus-driven genomic entropy
2 MIN READ
0
Let there be anti-entropic light (2)
4 MIN READ
0
Non-mainstream scientist shares Nobel prize in Medicine
3 MIN READ
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Is mainstream science in “Science” pseudoscience?
5 MIN READ
0
Hijacked light energy and vertebrate pathology
4 MIN READ
0
Theorists have not seen the light
4 MIN READ
0
Exosomes and the RNA-mediated future of medicine
5 MIN READ
0
Multi-omic analysis features (SNPs, miRNA)
3 MIN READ
0
Somatic hypermutation vs RNA-mediated events
2 MIN READ
0
Phytochemical link from the sun to cell types
2 MIN READ
0
New anti-entropic microbes
3 MIN READ
0
Genome sequencing, cadherins, and quantum consciousness
6 MIN READ
0
Anti-entropic containment of energy: symbiosis 1.0
5 MIN READ
0
The “great filter” is an epigenetic trap
4 MIN READ
0
Atomic-resolution of cell type signaling
4 MIN READ
0
Information and communication (2)
6 MIN READ
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Olfaction & the octopus and human genomes (2)
4 MIN READ
0
The stability of organized genomes (4)
3 MIN READ
0
The stability of organized genomes (3)
3 MIN READ
0
Viruses, amino acids, and somatic cell types (2)
5 MIN READ
0
Picornaviruses moving between primates (or not)
2 MIN READ
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Riding the wrong direction
3 MIN READ
0
MicroRNA – controlled ecological adaptations
5 MIN READ
0
Becoming biologically informed (2)
3 MIN READ
0
Is SUMOylation RNA-directed DNA methylation? (revisited)
4 MIN READ
0
“New” epigenetic mechanism for lifelong learning?
3 MIN READ
0
RNA-mediated development (2)
< 1 MIN READ
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Ignoring top-down causation
2 MIN READ
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Unknown mechanisms and conclusions
2 MIN READ
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Alternative splicings: epigenetics meets pharmacogenomics
4 MIN READ
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Pattern recognition: biogeochemical structure and function
5 MIN READ
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Viruses and the human-like microbiome
3 MIN READ
0
Informing the biologically uninformed
< 1 MIN READ
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Bees and primates automagically evolve
3 MIN READ
0
Ignoring systems complexity (it’s too complicated)
3 MIN READ
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Virus-driven cancer treatment and prevention
2 MIN READ
0
A special issue on nutritional epigenetics
5 MIN READ
0
Retinoic acid + one receptor regulate the genome
3 MIN READ
0
Epigenetics: microRNAs effect an integrative pathway
4 MIN READ
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Viruses in gut microbes
4 MIN READ
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Epigenetics vs the fossil record
4 MIN READ
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RNA-mediated silencing of a chromosome
3 MIN READ
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Amino acid-dependent cell type differentiation
8 MIN READ
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Silencing genes and serious scientists
3 MIN READ
0
MicroRNAs and memory
< 1 MIN READ
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Creating nothing but a theory (2)
4 MIN READ
0
Viruses and ecologically adapted animals
2 MIN READ
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Epigenetic switch links MicroRNAs to RNA-protein interactions
4 MIN READ
0
Quantum correlations/pseudoscience
3 MIN READ
0
Mimicking claims and ignoring facts
4 MIN READ
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Correctly modeling biological energy
2 MIN READ
0
Questions about life’s diversity
21 MIN READ
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RNA-directed gene choice
5 MIN READ
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From 3-D to epigenetically-effected 4-D genome make-up
5 MIN READ
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Nutritional epigenetics, exercise, and immune system integrity
4 MIN READ
0
What if Darwin was not still dead?
2 MIN READ
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Are viruses microRNAs? (2)
5 MIN READ
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Sneaking up from behind
4 MIN READ
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All of “like kind” (Part 2)
2 MIN READ
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From Hydra to humans vs a Lakatosian research program
4 MIN READ
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Dual genomes: exposing the evolution industry
5 MIN READ
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Epigenetic pharmacology and RNA-mediated transciptional landscapes
3 MIN READ
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Biologists puzzled by evolved RNAs and decaying DNA
6 MIN READ
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More than a bag of chemicals?
2 MIN READ
0
Intelligent viruses and cancers?
10 MIN READ
0
RNA eclipses the importance of DNA to cell type differentiation
4 MIN READ
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Pharmacogenomics
3 MIN READ
0
It’s cell type differention, not cell fate determination (2)
3 MIN READ
0
Are evolutionary theorists 'nob ends'?
5 MIN READ
2
No understanding of biodiversity
2 MIN READ
0
Behavioral ecology: please continue to believe in our fantasies
3 MIN READ
0
Color vision refutes the evolutionary dogma of gene duplication
4 MIN READ
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Genomic surveillance ends our world of RNA-mediated ecological adaptations
2 MIN READ
0
RNA-mediated cell type differentiation and behavior
3 MIN READ
0
RNA-directed DNA methylation and RNA-mediated events
5 MIN READ
1
RNA-mediated species diversification from microbes to primates
3 MIN READ
0
Genotype, observed phenotype, and distinctly disordered behaviors
3 MIN READ
0
RNA-mediated ecological adaptation is not evolution
2 MIN READ
0
Exploding genomes and chromosomal rearrangements via RNA-mediated events
2 MIN READ
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Behavior (2): All responses are RNA-mediated not genetically-determined
4 MIN READ
0
A relatively young branch of science called epigenetics
4 MIN READ
0
Comparing divergent model organisms
2 MIN READ
1
A microRNA-mediated mechanism that is epigenetically inherited
2 MIN READ
0
Order and disorder: Ecological adaptations not mutations
6 MIN READ
0
microRNAs differentiate neuronal cell types
3 MIN READ
0
microRNAs and species relationships
3 MIN READ
0
Drunks and Monkeys: Pseudoscientific nonsense
2 MIN READ
0
Nutrition, pheromones and cancer (2)
2 MIN READ
0
Cell-type differentiation
2 MIN READ
0
Another powerful refutation of mutation-initiated natural selection
4 MIN READ
0
96 fixed amino acid substitutions, not 96 genes
6 MIN READ
0
Alternative splicings (very technical)
2 MIN READ
0
Social experiences epigenetically effect gene networks
2 MIN READ
0
Understanding the role of mutations and evolution
4 MIN READ
0
Alzheimer's, microRNAs, and olfaction
< 1 MIN READ
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Evolution: innovations may have non-adaptive origins (sans mutations)
2 MIN READ
0
Pheromones and cancer
4 MIN READ
0
Constraints on mutational drift
< 1 MIN READ
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Epigenetic effects underlie sexual preferences IV
< 1 MIN READ
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The hormone-miRNA axis, life span, and sexual orientation
3 MIN READ
0
Modeling epigenome dynamics: Polycomb
2 MIN READ
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MicroRNA binds messenger RNA: Adaptive Evolution
< 1 MIN READ
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Disorders of development: altered microRNA / messenger RNA balance
< 1 MIN READ
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Evolution at work sans random mutations
2 MIN READ
0
Sex differences in Alzheimer's and everything else
2 MIN READ
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