God’s protection from SARS COV-2 and other viruses (2)

By: James V. Kohl | Published on: December 9, 2020

Is the mask-wearing and social distancing pseudoscientific nonsense based on inefficiency, incompetency or the intent to take away the individual liberties of patriots and others in the USA?

See the Research Topic Ecological Change as A Driver for Evolution of Animal Influenza Viruses: Genetic variation, Adaptation, Cross-species transmission, and Host Immunity

The first article of this Research Topic linked natural selection for energy-dependent codon optimality from the physiology of reproduction to healthy longevity across kingdoms via Bazzini (2019). Genome-Wide Study Reveals a Novel Regulatory Pathway: Translation Affects mRNA Stability in a Codon-Dependent Manner

See:  Altering Intracellular Localization of the RNA Interference Factors by Influenza A Virus Non-structural Protein 1 11/12/20

 …a mutation selected against during evolution… confers an important biological phenotype.

Selection against mutations is required for codon-dependent mRNA stability.
See for comparison: Genetic dissection of assortative mating behavior 2/17/19

Ecologically relevant mating cues (sometimes known as “magic traits” [2,6]) are now predicted to be widespread in nature [6,7], and the last few years have seen considerable progress in our understanding of their genetic basis.

Claims about “magic traits” must now be compared to claims about selection against mutations. Selection against mutations exemplifies God’s intent to protect us from the virus-driven degradation of messenger RNA via His Creation of the energy-dependent/nutrient-dependent pheromone-regulated genetic processes of ecological adaptations across kingdoms.
But see also: The Darwin Code: Intelligent Design without God if you want to keep God out of it because you are a biologically uninformed theorist like the science journalist Philip C. Ball.
See from 6/24/17:

See for comparison: Entropy as a Robustness Marker in Genetic Regulatory Networks 2/25/20

Between these extreme molecular and population levels, identical functions can be concerned from different species: from paramecia, a plant-like Bidens pilosus to humans as memory function [49,94] or motion control [95,96,97]. Because the corresponding regulatory systems are often random, future work will be done in the framework of general random systems [98]—in which the notions of entropy, stochastic attractor (confiner) and invariant measure can help to interpret and classify the observed data in many regulatory networks (neural, genetic, metabolic, social, etc.)—and in biomedical fields for practical applications (see for example [61,99]).

Compare the claims about motion control, random regulatory systems, and entropy-linked genetic regulatory networks in Bidens pilosus to facts about the light-activated weekend resurrection of the bacterial flagellum.

The facts about the weekend evolution of the bacterial flagellum link quantum coherence to coherently organized biology across kingdoms via fixation of two amino acid substitutions in P. fluorescens.
The facts were placed into the context of biophysically constrained SARS-CoV-2 viral latency in: A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmission (2007) and light-activated microRNA biogenesis in plants was linked to Differential microRNA expression and virulence of avian, 1918 reassortant, and reconstructed 1918 influenza A viruses (2011)
It has since become perfectly clear to all intelligent serious scientists that MicroRNAs organize intrinsic variation into stem cell states 3/5/20

…the results presented here suggest that naturally arising cell-to-cell variation, sometimes described as stochastic fluctuation, is in fact coherently organized biology.

See also: RNA Secondary Structure as a First Step for Rational Design of the Oligonucleotides towards Inhibition of Influenza A Virus Replication 11/7/20

In light of the continuous evolvement of IAV and its increasing resistance to existing drugs and vaccines, finding target sites in IAV RNA that are sequentially or structurally conserved and less prone to drug resistance is a very important issue. That conclusion could be extended to other RNA viruses, including SARS-CoV-2. A novel therapy concerning the regulation of pathogenic RNA by using RNA-targeting strategies is still being developed.

The first step for rational design of the molecular mechanisms that inhibit viral replication requires God’s Creation of hydrogen and water for the link to oxidative phosphorylation and constrained viral latency across kingdoms.
The patent for naturally occurring light-activated carbon fixation and biophysically constrained viral latency across kingdoms attests to the fact that claims about RNA-targeting strategies, which are still being developed, are made by profiteers who will continue to contribute to unnecessary suffering and premature death.
See for instance: RNA-Guided Human Genome Engineering

5. Repetitive elements or endogenous viral elements can be targeted with engineered Cas+gRNA systems in microbes, plants, animals, or human cells to reduce deleterious transposition or to aid in sequencing or other analytic genomic/transcriptomic/proteomic/diagnostic tools (in which nearly identical copies can be problematic).

See also: MicroRNA Involvement in Signaling Pathways During Viral Infection 3/10/20

Knowing the roles of miRNAs in host response to various viral infections provides an interesting tool for identifying key genes and pathways that must be activated, enhanced, silenced or repressed in order to impel an effective immune response.

See also: The Global Phosphorylation Landscape of SARS-CoV-2 Infection 6/28/20

The pathophysiology of severe coronavirus disease 2019 (COVID-19) is similar to that of severe disease caused by SARS-CoV and is characterized by acute respiratory distress and excessive inflammation capable of inducing respiratory failure, multi-organ failure, and death (; ).

The pathophysiology of all virus-driven diseases was linked to constraint-breaking mutations in 1964. See: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” 

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

McEwen et al., (1964) started with God’s energy-dependent Creation of ATP and RNA.
Theorists start with the emergence of energy from the void and link it to the “magic traits” of ecological adaptations. Have you ever tried to discuss facts with a theorist? Many of them are extremists.
See: Respectful disagreement cannot divide us 10/20/20

National Commander Daniel Foley, wrote a message in 1964 that still resonates. What follows is an abbreviated version of his magnificent words:

“At a time of rapid change and recurring crisis in national affairs, one factor remains constant. The loudest noise and the most confused counsel continue to come from extremists.

The extremists have become “public-health patriots” who fully intend to eliminate the “individual-liberty patriots” from consideration. See Separated we survive 9/29/20

Partnering with educators, we can share America’s story, explain why we sometimes must sacrifice for the public good and sometimes must fight for individual liberty, and remind young Americans – and each other – that what unites us is bigger than what separates us.

USA veterans have sacrificed many things, including their lives, for the public good, which equates with individual liberty. That fact is bigger than what separates us. What separates is the pseudoscientific nonsense touted by biologically uninformed theorists and their supporters for comparison to those who support the American Legion’s Motto: “For God and Country.”

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