Impeaching the God of Abraham (6)
(click to enlarge)
I repeat: “The epigenetic effects of olfactory/pheromonal input calibrate and standardize molecular mechanisms for genetically predisposed receptor-mediated changes in intracellular signaling and stochastic gene expression…”
Catalytic Asymmetric Synthesis of the anti‐COVID‐19 Drug Remdesivir 9/1/20
The catalytic asymmetric synthesis of the anti-COVID-19 drug Remdesivir… showed that this DyKAT is a first-order visual kinetic reaction dependent on the catalyst concentration. The unique chiral bicyclic imidazole skeleton and carbamate substituent of the catalyst are both required for the racemization process…
The racemization process involved a subsequent stereodiscriminating step that was linked to its potential for industrial application.
See for comparison this link to a naturally occurring process: Catalytic asymmetric and stereodivergent oligonucleotide synthesis 2/12/21
Two different CPA scaffolds have proven to be essential for achieving stereodivergence: peptide-embedded phosphothreonine-derived CPAs, which reinforce and amplify the inherent substrate preference, and C2-symmetric BINOL-derived CPAs, which completely overturn this stereochemical preference. The presently reported catalytic method does not require stoichiometric activators or chiral auxiliaries and enables asymmetric catalysis with readily available phosphoramidites.
Even if you start with Peptide synthesis at the origin of life and “…peptide-embedded phosphothreonine-derived CPAs…’ you may never be able to fully grasp the extent of what gene-centric theorists will do to try to support the pseudoscientific nonsense of their gene-centric theories.
But see: Crosstalk between codon optimality and cis-regulatory elements dictates mRNA stability 1/5/21
…it is the driving power represented by the oxidation potential of the radical ion, which controls the repair. Thus, repair capacities are strongly sequence-dependent, creating DNA regions with different tendencies of self-repair. This self-healing activity represents the simplest sequence-dependent DNA repair system.
See also: Oxidation-dependent ion-mediated DNA repair was linked from photosynthesis to protonated RNA interference via Quintillionths of a second in slow motion (2018)
An important intermediary step in many chemical processes is ionization. A typical example of this is photosynthesis. The reactions take only a few femtoseconds (quadrillionths of a second), or even a few hundred attoseconds (quintillionths of a second). Because they run so extremely fast, only the initial and final products are known, but not the reaction paths or the intermediate products.
Femtosecond blasts of UV light repair virus-damaged DNA. The reaction paths and intermediate products link subatomic particles to biophysically constrained viral latency in the context of the cell biology game “Cytosis” and the forthcoming game “Subatomic.” Cryo-EM technology is the key to linking energy-dependent changes in electron spin to all biodiversity via the physiology of reproduction in all living genera.
It is tempting to link the works of all theorists to examples of human idiocy via
Virus-cutting enzyme helps bacteria remember a threat 2/20/15
Our work reveals an overlooked role for Cas9: forming the memories that make adaptive immunity possible for bacteria,” Marraffini says.
The role of viral microRNAs in the inhibition of cell type differentiation has become much clearer during the past decade in the context food energy-dependent microRNAs. The contrast links the epigenetic landscape to the biophysically constrained chemistry of protein folding via the conserved molecular mechanisms of RNA-directed DNA methylation and RNA-mediated amino acid substitutions.
What remains to be seen is how thermodynamic cycles of nutrient-dependent protein biosynthesis and degradation are constrained by the physiology of reproduction, which enables the entropic plasticity of epigenesis that leads to anti-entropic epistasis in species from microbes to man.
Want more on the same topic?
Swipe/Drag Left and Right To Browse Related Posts:
Pheromone-regulated genetic processes (3)
3 MIN READ
0
Separated we survive (2)
3 MIN READ
0
Biophotonically charged life (9)
2 MIN READ
0
Biophotonically charged life (2)
2 MIN READ
0
Codon optimality vs systemic fraud (10)
3 MIN READ
0
Biophotonically charged life (1)
3 MIN READ
0
Codon optimality vs systemic fraud (7)
3 MIN READ
0
Codon optimality vs systemic fraud (5)
6 MIN READ
0
Crimes against humanity (1)
5 MIN READ
0
Codon optimality vs systemic fraud (3)
2 MIN READ
0
Epistemic corruption (10)
4 MIN READ
0
Epistemic corruption (3)
2 MIN READ
0
MicroRNA-mediated existential threats (8)
4 MIN READ
0
MicroRNA-mediated existential threats (2)
2 MIN READ
0
MicroRNA-mediated existential threats (1)
4 MIN READ
0
Photonics in Forensics (6)
2 MIN READ
0
Photonics in Forensics (5)
4 MIN READ
0
Peptide synthesis and therapy update 2/28/22
< 1 MIN READ
0
RNAi 2002 to AI 2021 (5)
2 MIN READ
0
RNAi 2002 to AI 2021 (3)
3 MIN READ
0
RNAi 2002 to AI 2021 (1)
3 MIN READ
0
microRNA-mediated cures (9)
3 MIN READ
0
microRNA-mediated cures (7)
2 MIN READ
0
Naturally attenuated viral endemicity (9)
1 MIN READ
0
Naturally attenuated viral endemicity (4)
2 MIN READ
0
Orchestrated death: Francis S. Collins (2)
4 MIN READ
0
Orchestrated death: Kevin J. Mitchell
2 MIN READ
0
God’s microRNA-mediated Creation of genotypes (4)
3 MIN READ
0
MicroRNA-mediated population control (10)
2 MIN READ
0
MicroRNA-mediated population control (9)
< 1 MIN READ
0
MicroRNA-mediated population control (4)
2 MIN READ
0
MicroRNA-mediated population control (2)
3 MIN READ
0
microRNA-mediated election cycles (1)
2 MIN READ
0
microRNA-mediated replication cycles (6)
2 MIN READ
0
Quantum biology vs atheism (1)
< 1 MIN READ
0
Quantum Darwinism (10)
3 MIN READ
0
Quantum Darwinism (9)
2 MIN READ
0
Quantum Darwinism (8)
2 MIN READ
0
Quantum Darwinism (4)
< 1 MIN READ
0
Quantum Darwinism (3)
3 MIN READ
0
Quantum Darwinism (1)
2 MIN READ
0
Pheromones protect us from viruses (10)
4 MIN READ
0
Pheromones protect us from viruses (8)
2 MIN READ
0
Defeating disease and Communism (4)
2 MIN READ
0
Defeating disease and Communism (3)
2 MIN READ
0
Impeaching the God of Abraham (9)
2 MIN READ
0
Impeaching the God of Abraham (1)
4 MIN READ
0
Life or death facts about theories (4)
3 MIN READ
0
Life or death facts about theories (1)
2 MIN READ
0
God’s protection from SARS COV-2 and other viruses (3)
2 MIN READ
0
God’s protection from SARS COV-2 and other viruses (1)
2 MIN READ
0
Racist fascism vs individual liberty (1)
3 MIN READ
0
Protonated RNA interference vs stupid theories (10)
2 MIN READ
0
The assassination of intelligence (1)
3 MIN READ
0
Protonated RNA interference vs stupid theories (7)
2 MIN READ
0
From optoribogenetics to HelioRiboGenetics (1)
2 MIN READ
0
The microRNA-mediated future of humanity (8)
4 MIN READ
0
The microRNA-mediated future of humanity (7)
4 MIN READ
0
The microRNA-mediated future of humanity (6)
4 MIN READ
0
The microRNA-mediated future of humanity (5)
< 1 MIN READ
0
The microRNA-mediated future of humanity (4)
4 MIN READ
0
The tipping point (revisited): 100K (2)
5 MIN READ
0
WHO’s ignorance: From roots to shoots (2)
3 MIN READ
0
The tipping point (revisited): 96K (1)
2 MIN READ
0
Dmitri Petrov refutes theistic evolution, again
3 MIN READ
0
mRNA Structure and Function (1)
2 MIN READ
0
Pheromones biophysically constrain disease (1)
2 MIN READ
0
#SFN2019 to 2012: Hiding the facts (7)
2 MIN READ
0
Patented Creation vs Evolution of Disease (5)
3 MIN READ
0
Chemogenetic kinetics (7): DHA vs consensus (3)
3 MIN READ
0
Chemogenetic kinetics (6): Plants-Mice-Cattle-Humans
5 MIN READ
0
Trans-kingdom RNA interactions (3)
3 MIN READ
0
Sunlight, hydrophobicity and biodiversity (3)
5 MIN READ
0
Bastardized health care (4)
4 MIN READ
0
Genetic endemism: apologetics vs epigenetics (2)
3 MIN READ
0
Codon-dependent mRNA stability (1)
5 MIN READ
0
The tipping point (revisited): 88K (2)
2 MIN READ
0
The tipping point (revisited): HYL1
3 MIN READ
0
Light and life-sucking black holes (3)
5 MIN READ
0
Olfaction and microRNA signaling constrain longevity (1)
4 MIN READ
0
Kohl and Francoeur at 25 (5)
2 MIN READ
0
Epic failure of the FDA: Gottlieb resigns (2)
2 MIN READ
0
Ecological adaptation vs neo-Darwinian nonsense (4)
2 MIN READ
0
Light-activated constrained biodiversity (2)
4 MIN READ
0
Life and death at base pair resolution (1)
< 1 MIN READ
0
The eternal significance of microRNAs and the Vietnam Memorial (1)
3 MIN READ
0
The eternal significance of microRNAs (8)
2 MIN READ
0
A single base change refutes theistic evolution
5 MIN READ
0
Environmental selection is natural selection
3 MIN READ
0
The eternal significance of microRNAs (4)
5 MIN READ
0
Do not refute cherished theories
2 MIN READ
0
From photons to the proton motive force (2)
3 MIN READ
0
Diet-driven RNA interference and cancer prevention (3)
6 MIN READ
0
Kinetically Stable Thermodynamically Activated Cell Metabolism (2)
4 MIN READ
0
Elsevier fails to support the concept of autophagy
4 MIN READ
0
From Autophagy.pro (transitions)
4 MIN READ
0
Two retractions of human idiocy
2 MIN READ
0
Natural selection for racism and all pathology
6 MIN READ
0
Proteins “evolve” (revisited)
2 MIN READ
0
Sci-Hub vs limits on the dissemination of information
6 MIN READ
0
Methylation and the Innate Immune System
< 1 MIN READ
0
Your indifference is killing you and others
5 MIN READ
0
The Origin of Information (4)
4 MIN READ
0
Energy-dependent physical and biophysical constraints (6)
8 MIN READ
0
Energy-dependent physical and biophysical constraints (3)
2 MIN READ
0
Energy-dependent physical and biophysical constraints (1)
5 MIN READ
0
Energy-dependent epigenetic translation to mRNA stability (5)
4 MIN READ
0
Energy-dependent epigenetic translation to mRNA stability (3)
5 MIN READ
0
Energy-dependent epigenetic translation to mRNA stability
8 MIN READ
0
What energy source do proteins prefer?
6 MIN READ
0
Energy-dependent microRNA biogenesis
4 MIN READ
0
Virus-driven downsizing of the human brain (4)
2 MIN READ
0
Open Science: Closed to facts about microRNAs
6 MIN READ
0
What is life without sunshine?
2 MIN READ
0
Functionally interdependent editing and methylation
4 MIN READ
0
Light-activated feedback loops vs self-organization of ecosystems
7 MIN READ
0
Sal Giardina: apologetics revisited
8 MIN READ
0
Theistic evolutionists fight back and lose (3)
4 MIN READ
0
Wikipedia refutes theistic evolution
4 MIN READ
0
Pseudoscientists fail to refute theistic evolution
4 MIN READ
0
Stuart Kauffman refutes theistic evolution
3 MIN READ
0
Francis S. Collins refutes theistic evolution
6 MIN READ
0
Energy is information. Objections over ruled. You’re fired!
7 MIN READ
0
Happy Darwin Day (2017)
4 MIN READ
0
George Church refutes theistic evolution (3)
5 MIN READ
0
George Church refutes theistic evolution (2)
2 MIN READ
0
Energy as information and constrained endogenous RNA interference (3)
4 MIN READ
0
Dobzhansky 1973 and precision medicine (5)
3 MIN READ
0
Dobzhansky 1973 and Precision Medicine (2)
5 MIN READ
0
Dobzhansky 1973 and precision medicine
6 MIN READ
0
Autophagy: from pre-mRNAs to microRNAs, enhancers, QTLs et al.
6 MIN READ
0
Energy-dependent hydrogen bonds in supercoiled DNA
7 MIN READ
0
Energy-dependent chirality (2)
3 MIN READ
0
Vietnam Veterans and others with glioblastoma
3 MIN READ
0
Energy-dependent sensory maps (1996-2016)
5 MIN READ
0
Energy-dependent oscillating gene networks organize life
4 MIN READ
0
2016 obfuscated facts about energy as information
5 MIN READ
0
More refutations of neo-Darwinian nonsense
7 MIN READ
0
Energy-dependent de novo creation and neurogenesis (2)
5 MIN READ
0
Tasting light links energy from creation to adaptation
9 MIN READ
0
De novo gene creation: Ignoring the experimental evidence
7 MIN READ
0
Energy-dependent coulombic, autophagic, polycombic healthy longevity
4 MIN READ
0
Epigenetically effected energy-dependent fluorescence (2)
6 MIN READ
0
From Precis to Proof in 6000 years (3)
2 MIN READ
0
Polycombic ecological adaptation as a science, not a theory
3 MIN READ
0
80 years of causal analysis (1936 – 2016)
11 MIN READ
0
Predictable idiosyncratic evolved convergence
3 MIN READ
0
The natural success of RNAi and failed treatment
7 MIN READ
0
Hecatombic evolution via oncocers and oncohistones
9 MIN READ
0
Did evolution autophosphorylate your kinases? (2)
5 MIN READ
1
Nutrient-dependent pheromone-controlled autophagy (2)
6 MIN READ
0
Nutrient-dependent pheromone-controlled autophagy
3 MIN READ
0
Life is energy-dependent task management
3 MIN READ
0
Hypothesis free pseudoscience vs facts (5)
6 MIN READ
0
The last RNA-mediated theory killer
< 1 MIN READ
0
Chromatin: The structure of DNA
6 MIN READ
0
DNA repair via junk DNA (2)
5 MIN READ
0
Light energy-induced base pair changes (2)
4 MIN READ
0
Light energy-induced base pair changes (1)
6 MIN READ
0
Lawless evolution: No physics
4 MIN READ
0
Virus-driven energy theft: honeybee model
3 MIN READ
0
Antithetical conclusions (4)
3 MIN READ
0
RNAi: From magic bullet to billion dollar baby
4 MIN READ
0
GC-rich neo-Darwinian train wreck
5 MIN READ
0
Biophotonics, glycobiology, quantized biodiversity (2)
19 MIN READ
0
The Origin of Information (1)
6 MIN READ
0
Light ‘drives’ adaptation; nothing ‘drives’ evolution
6 MIN READ
0
Molecular Diagnostics: What is unprotected life? (2)
7 MIN READ
0
