microRNA-mediated replication timing (4)

By: James V. Kohl | Published on: July 1, 2021

See first:
microRNA-mediated replication timing (1) 6/17/21
microRNA-mediated replication timing (2) 6/27/21
microRNA-mediated replication timing (3) 6/29/21
Non-B DNA: a major contributor to small- and large-scale variation in nucleotide substitution frequencies across the genome 1/15/21 was reported on 6/29/21 as Study provides first genome-wide evidence for functional importance of unusual DNA structures

Some regions of the human genome where the DNA can fold into unusual three-dimensional structures called c (G4s) show signs that they are preserved by natural selection.

The structural diversity of supercoiled DNA is microRNA-mediated in the context of epigenetic effects of nutrients on the physiology of reproduction that biophysically constrain replication timing, which is how the physiology of pheromone-regulated genetic processes controls replication stress in species from microbes to humans.
After former president Trump linked sunlight and humidity from biophysically constrained replication stress to weakened Covid19 on 4/23/20, natural selection for energy-dependent codon optimality was linked to the refutation of all stupid theories, and to the prevention or effective treatment of cancer in Crosstalk between codon optimality and cis-regulatory elements dictates mRNA stability on 1/5/21.
Biophyscially constrained RNA interference has been linked to mRNA stability by all intelligent serious scientists.

Nate Weymouth, who claims to be a “Pharmacologist Cell Biologist Patent Analyst,” and other biologically uninformed science idiots missed the scientific progress that was made during the past 25 years, after we reported on RNA-mediated cell type differentiation in the molecular epigenetics section of our 1996 Hormones and Behavior review: From fertilization to adult sexual behavior.
He exemplifies human idiocy in our discourse from twitter.  Others can see how futile it is to attempt discussion with pride-filled stupid academics.
NW: Frankly, you don’t know what you’re talking about. You’re taking credit for papers you don’t understand & didn’t do any work on. It appears you’re a med tech working in N GA who has no expertise in biomedical research or life sciences. Conflates science with religious beliefs.
JK: Please comment on my model, or the patent awarded to @geochurch et al for naturally occurring RNA interference (#RNAi). https://www.omicsonline.org/peer-reviewed/pnutrientdependent-pheromonecontrolled-ecological-adaptations-from-angstroms-to-ecosystemsp-101158.html Alternatively, offer a model for comparison. You stupid fool!
NW: Good grief, you’re full of boloney. Doubt George Church or Bill Marzluff even knows you. Now now a Christian wouldn’t insult or take credit for someone else’s patent. https://pic.twitter.com/LnxZhx6Oys
JK: My mentors, the late Robert L. Moss & the late Bruce S. McEwen linked energy-dependent changes in SNPs to all biodiversity across kingdoms. You will be credited for nonsense. https://www.sciencedirect.com/science/article/abs/pii/S0014480021000630 “rs11614913 is a polymorphism affecting function of miR-196a in complex diseases”
NW:  You didn’t do anything. You didn’t do any work on this technology from MIT and you don’t understand the papers you’re quoting. This is not your patent and you weren’t part of its prosecution.
JK: I exposed the fact that researchers from MIT and Harvard worked for Abcam at the time the death gene was discovered in the late 1990’s. See: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166303 You have done nothing important for comparison to help prevent virus-driven diseases such as cancer.
NW: There is nothing cogent in what you’re saying. You’re not cited on this paper nor any of the papers you quote. The one paper where you’re cited deals with sexual behavior, not vaccines, siRNA, mRNA therapeutics, or SNP. All word salad & excrement.
JK: You fool! Sex differences in cell types are microRNA-mediated in the context of food energy-dependent pheromone-regulated genetic processes of RNA interference. See the molecular epigenetics section in our 1996 review: https://pubmed.ncbi.nlm.nih.gov/9047261
NW: No you didn’t co author a book on processing of histone transcripts. Actually, I could ask Bill or Bert if you want? Bc I actually helped Bert with those experiments.
JK: Our target audience was intelligent people. Theorists ignored our claims, which made them look like the fools they have been since 1679. See: https://www.amazon.com/The-Scent-Eros-Mysteries-Sexuality/dp/059523383X for comparison to Merian’s “The Wondrous Transformation of Caterpillars and their Remarkable Diet of Flowers”
NW: You have exposed nothing. Suggest you read my CV closely. You keep quoting people I actually know. Don’t think you real want me to fact check your scientific background.
JK: Suggest you link the claims of Biden’s science advisor @EricLander46 to the claims of @geochurch et al., in the patent for naturally occurring light-activated carbon fixation and pH-dependent viral latency across kingdoms from cyanobacteria to humans. https://youtu.be/Vh3-NHdjnyQ
NW: This has nothing to do with histone mRNA processing.
JK: https://www.nature.com/articles/ncomms9440 “Structural diversity of supercoiled DNA” is https://youtu.be/gwy2lD1reos
Olfaction warps visual time perception of energy and mass across the space-time continuum at that level of biophysically constrained microRNA-mediated cell type differentiation. UFOOL!
NW: A Christian wouldn’t:
1) attack someone for being skeptical
2) take credit for the works of others
3) impose their unfounded beliefs on others
5) peddle inaccurate information
I am a Christian & respect your right to say whatever but you’re wrong scientifically
JK: Tell me what I am wrong about. Be specific! I’ve asked you to comment on my model. Are you too stupid to do that? It’s been more than 7 years since I published this refutation of stupid theories. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960065
NW: Why don’t you ask this guy @Kevin_McKernan who actually worked for Eric Lander? James you’re all over the place with your scientific claims and you conflate these unfounded claims with your religious beliefs.
JK: Why not ask @EricLander46? In 2012, he fully supported Trump’s 4/23/20 claim about the effect sunlight and humidity have on coronaviruses via RNA interference (#RNAi) The effects were revealed in https://science.sciencemag.org/content/315/5812/655.full (2007)
NW:: Nothing to do with histone mRNA processing. You’re not a research scientist. It is apparent you are a medical technologist performing tests at local hospital in N. Georgia. I have worked in some rigorous biomedical research labs, you haven’t. Go ask some of researchers you quote.
JK: Re: “I have worked in some rigorous biomedical research labs, you haven’t.”
Thank God. If I had learned what people taught you, I might not have recognized this scientific truth in 2013

“2013 was the year in which prophesy from the bible became reality.”
NW: Face it. You haven’t. Science shouldn’t be conflated with religious beliefs.
JK: Every intelligent serious scientist I know has linked God’s Creation of energy-as-information to pH-dependent biophysically constrained viral latency via the physiology of reproduction. See for example: https://www.frontiersin.org/article/10.3389/fphys.2018.01966 from the 2004 Templeton Prize winner and his friend.
NW: @markmcdougall13 this guy is a charlatan.
JK: George FR Ellis stated I was correct in his comment on https://journal.frontiersin.org/article/10.3389/fnhum.2014.00127/full “This is absolutely correct and forms part of the larger concept that top-down causation is a key factor not just in the way the brain works but in broader contexts in biology and even physics.”

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