microRNA-mediated replication timing (5)

By: James V. Kohl | Published on: July 2, 2021

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Facts about energy-dependent microRNA-mediated biophysical constraints, which link protonated RNA interference (RNAi) to cell type differentiation across kingdoms via the physiology of reproduction and fixation of amino acid substitutions in organized genomes, are included in:

pre-mRNA spatial distributions suggest that splicing can occur post-transcriptionally 6/29/21

Our results suggest a model in which transcription and splicing are largely independent, and the existence of a slow moving zone around the transcription site allows for the unification of co-transcriptional and post-transcriptional models of splicing.

The “slow moving zone” is required to link energy-dependent changes in autophagy to microRNA-mediated RNA interference in the context of microRNA-mediated replication timing and the patent for naturally occurring light-activated carbon fixation, which has been linked to the prevention or effective treatment of all virus-driven pathology.
See: RNA-Guided Human Genome Engineering

5. Repetitive elements or endogenous viral elements can be targeted with engineered Cas+gRNA systems in microbes, plants, animals, or human cells to reduce deleterious transposition or to aid in sequencing or other analytic genomic/transcriptomic/proteomic/diagnostic tools (in which nearly identical copies can be problematic).

Former US President, Donald J. Trump placed this into a concise statement on 4/23/20. This initial report was changed from the claim that President Donald Trump touted a federal study Thursday that indicates sunlight and humidity can weaken the coronavirus – a finding that prompted the president to float the idea of treating patients with “light inside the body.”
The change was to “The genesis of Trump’s remarks was a Department of Homeland Security study that found the lifespan of the virus on a surface or in the air could be significantly reduced by exposure to sunlight, humidity and other factors.”
For comparison, this claim soon went missing in most of the curated news:

Jonathan Reiner, professor of medicine at The George Washington University Hospital, said there’s no medical basis for Trump’s statements about sunlight.

Everything known to intelligent serious scientists such as Edward S. Boyden, Shelley L. Berger, and Arjun Raj, can be linked from God’s Creation of sunlight and humidity to food energy-dependent pheromone-regulated genetic processes of reproduction via epigenetic effects on cell type differentiation manifested in the social behavior of species from microbes to humans.
For example, see: Epigenetic Regulator CoREST Controls Social Behavior in Ants 11/12/19 and the section on molecular epigenetics from our 1996 Hormones and Behavior review of RNA-mediated cell type differentiation. From Fertilization to Adult Sexual Behavior.
See also: Social reprogramming in ants induces longevity-associated glia remodeling 8/19/20.
Atheists, Communists, other pseudoscientists, and all biologically uninformed science idiots have been forced to respond to experimental evidence of validated scientific progress with claims like these:

Nurse cell–derived small RNAs define paternal epigenetic inheritance in Arabidopsis 7/2/21 reported as Small RNAs on the move in male germ cells and How information beyond the genetic sequence is encoded in the plant sperm

How this process worked during plant reproduction has until now, been unclear.

The exciting research, published in Science, reveals the molecular mechanism of DNA methylation reprogramming in the male germline of plants.

Nothing has been unclear since 1964. Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation”

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

Start with God’s ATP-dependent synthesis of RNA, and see for comparison: Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems 4/18/18

…olfactory/pheromonal input links food odors and social odors from the epigenetic landscape to the physical landscape of supercoiled DNA in the organized genomes of species from microbes to man during their development.

See also: Barcoded oligonucleotides ligated on RNA amplified for multiplexed and parallel in situ analyses 3/8/21 with co-authors Edward S Boyden, George M Church (To whom correspondence should be addressed.)

We used fluorescence in situ sequencing to detect error-robust 8-base barcodes associated with each of these genes. We then used this data to uncover the spatial relationship among cells and transcripts by performing single-cell clustering and gene–gene proximity analyses.

Write to George M. Church, and ask if light-activated fluorescence in Pseudomonas fluorescens linked two amino acid substitutions from the weekend resurrection of the bacterial flagellum to his claims about light-activated carbon fixation in cyanobacteria.
See:

The claims of George M. Church about cyanobacteria have been linked to all biologically-based diversity on Earth via light-activated carbon fixation and nutrient-dependent pheromone-controlled RNA interference (RNAi) in species from microbes to humans.
Remember, the color and fragrance of flowers depends on light-activated microRNA-mediated replication timing in the context of RNA interference. See: Striking a balance: Trade-offs shape flower diversity 7/1/21 and this representation of facts about RNA interference by Biden’s scientific advisor, Eric Lander from 2012.