microRNA-mediated replication cycles (9)

By: James V. Kohl | Published on: July 6, 2021

See first: microRNA-mediated replication cycles (8)
Rotavirus research: 2014-2020 7/2/21

A temperature sensitive mutant… in the triplet encoding amino acid 138 of VP1 (L138P)…was separately expressed as a… protein, shown to interact with viroplasm-like particles (VLPs) in uninfected cells and to synthesize RNA in vitro…”

My summary: The rotavirus steals the energy required for the ATP-dependent synthesis of RNA, which typically biophysically constrains viral latency across kingdoms. Contextual constraints occur via light-activated carbon fixation, oxidative phosphorylation and RNA interference (RNAi).
RNAi links pheromone-regulated genetic processes and the physiology of reproduction to healthy longevity in species from microbes to humans. Plant growth linked to what organisms eat is the key to the Creation of RNAi.
Rotavirus research has shown that viruses steal the food energy that sustains healthy longevity at every level of examination from changes in angstroms to ecosystems.
Luis P. Villarreal did not understand why I failed to include information on the evolution of the vomeronasal organ (VMO) in what he referred to as “The Kohl Papers.” Had he linked the virus-driven degradation of messenger RNA from mutations to all pathology, he would know why intelligent serious scientists do not base their claims on stupid theories. For differences between stupid theories and facts about biophysically constrained viral latency, see the links to additional presenters during this conference. How Evolution Learnt to Learn 7/6/22 – 7/9/22
Note, Koonin, Krupovic, and other theorists have been forced to abandon their stupid theories because bacterial and archaeal adaptive immunity is energy-dependent and innate.
Mart Krupovic >
Département de Microbiologie, Institut Pasteur, Paris, France
Spindle-shaped viruses infect marine ammonia-oxidizing thaumarchaea 7/16/19

…viral predation has a profound impact on thaumarchaeal functioning and mortality, thereby regulating global biogeochemical cycles.

Eugene Koonin >
National Center for Biotechnology Information, National Institutes of Health, Bethesda, USA

CRISPR: a new principle of genome engineering linked to conceptual shifts in evolutionary biology 1/19/19

The CRISPR-Cas systems of bacterial and archaeal adaptive immunity have become a household name among biologists…

Igor Kovalchuk >
Department of Biological Sciences, University of Lethbridge, Lethbridge, Alberta, Canada
Christopher Lennon >
Microbiology. Murray State University, USA
Erez Levanon >
The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat-Gan, Israel

Stem cells. m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation 2/27/15

Colin Logie >
Molecular Biology Department, Radboud University, Nijmegen, The Netherlands
Frank Lyko >
Division of Epigenetics, German Cancer Research Center, Heidelberg, Germany

Rapid Epigenetic Adaptation in Animals and Its Role in Invasiveness 8/1/20

John Mattick >
Garvan Institute of Medical Research, Sydney, Australia

The State of Long Non-Coding RNA Biology 8/10/18 Update: Neural activity controls mitochondrial transfer of RNA modifiers to the nucleus  2/4/21 by John Hewitt

Patrick McGowan >
Cell and Systems Biology, Psychology and Physiology, University of Toronto, Canada

Epigenetic pathways through which experiences become linked with biology 5/6/15

Karin Moelling >
Max Planck Institute for Molecular Genetics, Berlin, Germany

The intron-enriched HERV-K(HML-10) family suppresses apoptosis, an indicator of malignant transformation 12/7/16

David S. Moore >
Pitzer College and Claremont Graduate University, Claremont, California, USA

Behavioral epigenetics 12/1/16

Mariusz Nowacki >
Institute of Cell Biology, University of Bern, Switzerland

RNA-mediated transgenerational inheritance in ciliates and plants 12/11/17

Programmed genome rearrangements in ciliates 5/27/20

Barry Pogson >
ARC Centre of Excellence in Plant Energy Biology, The Australian National University, Acton, Australia

Reconsidering plant memory: Intersections between stress recovery, RNA turnover, and epigenetics 2/19/16

Excess Light Priming in Arabidopsis thaliana Genotypes with Altered DNA Methylomes 9/4/19

Minoo Rassoulzadegan >
Inserm, U1091, Nice, F-06108, France

Sperm RNA: Quo vadis? 7/12/19

Oded Rechavi >
Department of Neurobiology, Wise Faculty of Life Sciences & Sagol School of Neuroscience, Tel Aviv University, Israel

Neuronal Small RNAs Control Behavior Transgenerationally 6/6/19

Stress resets ancestral heritable small RNA responses 3/17/21

Johannes Reul >
Neuro-Epigenetics Research Group, Bristol Medical School, University of Bristol, Bristol, UK
Tania L. Roth >
Department of Psychological and Brain Sciences, University of Delaware, USA
Marcel Schulz >
Institute of Cardiovascular Regeneration, Uniklinikum and Goethe University, Frankfurt, Germany
CpG content-dependent associations between transcription factors and histone modifications 4/15/21
Upasna Sharma >
Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, USA
Jason Shepherd >
Departments of Neurobiology, Biochemistry and Ophthalmology & Visual Sciences, University of Utah, Salt Lake City, USA
Marla Sokolowski >
Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Canada

Biological embedding of experience: A primer on epigenetics 10/17/19

Corrado Spadafora >
Laboratory of Translational Pharmacology, National Research Council, Rome, Italy

Transgenerational epigenetic reprogramming of early embryos: a mechanistic model 7/18/20

Moshe Szyf >
Department of Pharmacology and Therapeutics, McGill University Medical School, Montreal, Canada

Perinatal stress and epigenetics

Data that have emerged in the last 15 years suggest that like its role in defining cell-specific phenotype during development, DNA methylation might be involved in defining experiential identities, programming similar genes to perform differently in response to diverse experiential histories.

Katalin Fejes Tóth >
Division of Biology and Bioengineering, California Institute of Technology, Pasadena, USA

Small but sturdy: small RNAs in cellular memory and epigenetics 3/1/14

The piRNA Pathway Guards the Germline Genome Against Transposable Elements 8/19/16

Peter Unrau >
Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, Canada
Gianluca Ursini >
Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, USA

Brain-derived neurotrophic factor and schizophrenia 10/29/19

…BDNF represents a potentially relevant gene for schizophrenia, and indeed BDNF and its non-synonymous functional variant, rs6265 (C → T, Val → Met) have been widely studied in psychiatric genetics.

The social and winding road between inflammation and PTSD 2/18/21

Gertrudis Van de Vijver >
Centre for Critical Philosophy, Gent University, Belgium

No genetics without epigenetics? No biology without systems biology? 10/15/09

Sophie Juliane Veigl >
Cohn Institute for the History and Philosophy of Science and Ideas, Tel Aviv, Israel

Seeing “Lamarckian” More Positively: The Use/Disuse Paradigm Increases Understanding 5/20/19

Luis Villarreal >
Center for Virus Research, Department of Molecular Biology and Biochemistry, Irvine, USA

Force for ancient and recent life: viral and stem-loop RNA consortia promote life 11/6/14

My comment: May the Creator of “The “Force” be with you if you insist on touting more pseudoscientific nonsense.
See for comparison:
Guenther Witzany >
Telos-Philosophische Praxis, Buermoos, Austria

Memory and Learning as Key Competences of Living Organisms 4/24/18

What is Life? 3/18/20

…new nucleotide sequences now appear to have originated from social agents such as viruses, their parasitic relatives, and related RNA networks, not from errors.

A new definition of life must integrate the current empirical knowledge about interactions between cells, viruses, and RNA networks to provide a better explanatory power than the twentieth century narrative.

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