microRNA-mediated election cycles (3)
See: microRNA-mediated election cycles (2)
The most recent addition to the 124,062 indexed published works that mention ‘microRNA’ is A paradigm shift in cell-free approach: the emerging role of MSCs-derived exosomes in regenerative medicine
For background on this paradigm shift, see the following works: US Air Force Studying Impact of Exome Sequencing in Routine Care 10/19/17
The special considerations around fitness for duty and privacy make this a particularly challenging study to design and implement, but also an extremely important domain in which to gather empirical data around benefits and risks.
On 7/7/21, researchers from China and the USA published: A dual-luciferase reporter system for characterization of small RNA target genes in both mammalian and insect cells
They linked the light-activated assembly of the microRNA-RNA-peptide nanocomplex to biophysically constrained viral latency and healthy longevity via pheromone-regulated genetic processes of reproduction in species from insects to primates and the claims from MicroRNAs organize intrinsic variation into stem cell states, which linked quantum coherence to coherently organized biology.
…naturally arising cell-to-cell variation, sometimes described as stochastic fluctuation, is in fact coherently organized biology.
The molecular mechanisms of virus-related malignant transformation of non-tumorous tissues are diverse and involve molecules encoded by viruses or induced on viral infection.
Similar published works led George M. Church to collaborate with the Chinese and publish Regulation of host and virus genes by neuronal miR-138 favours herpes simplex virus 1 latency 2/8/21
The similar works include works that attest to how viral latency is biophysically constrained by microRNAs. Here are a few that cite MicroRNA Involvement in Signaling Pathways During Viral Infection
See for instance:
The Enigma of Low COVID-19 Fatality Rate in India 7/28/20
The Role of Non-coding RNAs in Viral Myocarditis 8/6/20
SARS-CoV-2 may regulate cellular responses through depletion of specific host miRNAs 8/31/20
MiRNAs: A Powerful Tool in Deciphering Gynecological Malignancies 10/23/20
MicroRNA-Based Fingerprinting of Cervical Lesions and Cancer 11/15/20
Comprehensive MicroRNA Expression Profile of the Mammary Gland in Lactating Dairy Cows With Extremely Different Milk Protein and Fat Percentages 12/3/20
Unravelling host-pathogen interactions: ceRNA network in SARS-CoV-2 infection (COVID-19) 12/15/20
MicroRNAs for Virus Pathogenicity and Host Responses, Identified in SARS-CoV-2 Genomes, May Play Roles in Viral-Host Co-Evolution in Putative Zoonotic Host Species 1/16/21
Regulation of Hedgehog Signaling by miRNAs and Nanoformulations: A Possible Therapeutic Solution for Colorectal Cancer 1/7/21
MicroRNAs and Natural Compounds Mediated Regulation of TGF Signaling in Prostate Cancer 1/27/21
MicroRNA Mimics or Inhibitors as Antiviral Therapeutic Approaches Against COVID-19 2/27/21
The Roles of MicroRNAs in Male Infertility 3/13/21
microRNA-21: a key modulator in oncogenic viral infections 3/22/21
The potential of miRNA-based therapeutics in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection: a review 3/24/21
The role of microRNAs in modulating SARS-CoV-2 infection in human cells: a systematic review 3/31/21
Downregulation of miR-218 by porcine reproductive and respiratory syndrome virus facilitates viral replication via inhibition of type I interferon responses 4/20/21
Announcements linked to publication of Mitochondrial-derived vesicles compensate for loss of LC3-mediated mitophagy 6/24/21 and to Developmental Consequences of Defective ATG7-Mediated Autophagy in Humans 6/24/21 claim that this is groundbreaking work.
I responded to the announcements with this comment: “Energy-dependent autophagy was linked to the ATP-dependent microRNA-mediated peptide synthesis at the origin of life and the creation of RNA in 1964.”
I provided the link to Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” (1964)
The synthesis of RNA in isolated thymus nuclei is ATP dependent.
Then I read that: Cells have evolved highly regulated and complex mechanisms to maintain mitochondrial homeostasis involving mitochondrial biogenesis, dynamics, and turnover.
Virus-driven energy theft causes defective autophagy. The facts have been linked from Eukaryotic plankton diversity in the sunlit ocean 5/22/15 to global biogeochemical cycles of protein biosynthesis and degradation in Virus-mediated archaeal hecatomb in the deep seafloor 10/12/16
No intelligent serious scientist has ever supported the claim that Cells have evolved highly regulated and complex mechanisms.
Instead, former President Donald J. Trump established the fact that microRNA-mediated cell type differentiation is pH dependent via his claim that sunlight and humidity weakend COVID-19.
Some people do not recognize that pH stands for the potential of hydrogen, which has been linked from God’s Creation of sunlight and humidity and hydrogen-atom transfer in DNA base pairs in solution to biophysically constrained viral latency and protonated RNA interference (RNAi).
Protonated RNAi protects organized genomes from the virus-driven degradation of messenger RNA (mRNA) because most organisms are not stupid enough to allow injection of synthetic mRNA.
For information on post-synthetic mRNA vaccine therapeutics that you may not have seen, see: Hydrogen: A Potential New Adjuvant Therapy for COVID-19 Patients 10/15/20 and 118 other articles on the topic of Coronavirus Disease (COVID-19): Molecular Mechanisms, Translational Approaches and Therapeutics