microRNA-mediated election cycles (6)
(click to enlarge)
Hyperglycaemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis 7/13/21
Conclusions: Hyperglycaemia-induced trained immunity… suggests new targets for disease prevention and therapy.
Reported on 7/14/21 as High blood sugar levels ‘reprogram’ stem cells
Our study is the first to show that diabetes causes long-term changes to the immune system… By focussing too narrowly on a managing a person’s blood sugar levels we’re only addressing part of the problem.
Every intelligent serious scientist in the world already knows how diabetes causes long-term changes to the immune system.Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation”
The synthesis of RNA in isolated thymus nuclei is ATP dependent.
More than 124,000 indexed published works link the light-activated assembly of the microRNA-RNA-peptide nanocomplex from carbon fixation to fixation of amino acid substitutions that differentiate all cell types in all individuals of all species via the physiology of reproduction.microRNA Viral Micro-RNAs Are Detected in the Early Systemic Response to Injury and Are Associated With Outcomes in Polytrauma Patients
Our findings suggest that transcription of viral micro-RNAs occurs early in the response to trauma and may be associated with the biological processes involved in polytrauma-induced complicated recovery.
Glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” were linked to the ATP-dependent Creation of RNA and differentiation of all cell types in 1964. George M. Church patented the naturally occurring process of light-activated carbon fixation and cell type differentiation as RNA-Guided Human Genome Engineering
5. Repetitive elements or endogenous viral elements can be targeted with engineered Cas+gRNA systems in microbes, plants, animals, or human cells to reduce deleterious transposition or to aid in sequencing or other analytic genomic/transcriptomic/proteomic/diagnostic tools (in which nearly identical copies can be problematic).
The repetitive elements are typically biophysically constrained in the context of energy-dependent fixation of amino acid substitutions manifested as endogenous retroviruses across kingdoms and as human endogenous retroviruses.VIDEO whaley k birgitta MicroRNAs organize intrinsic variation into stem cell states and what is known by former President Trump about how to prevent all virus driven pathology. See: MicroRNA Involvement in Signaling Pathways During Viral Infection Are multi-quasiparticle interactions important in molecular ionization?
The quantitative understanding of electronic excitations in complex molecular extended systems is one of the most fundamental open challenges in modern theoretical chemistry.
Accept the fact that modern theoretical chemistry cannot answer questions that have been answered by those who start with facts about God’s Creation of sunlight and humidity. The facts have been linked from RNA interference to protection from the virus-driven degradation of messenger RNA and all diseases since the dawn of Creation and Peptide synthesis at the origin of life 11/13/20
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2
0
Did Dobzhansky see the UV light of creation?
10
0
Manufacturing fossil “evidence”
4
0
RNA-mediated theory killers (4)
9
0
RNA-mediated theory killers (2)
8
0
MicroRNAs vs Red Queen hypothesis
4
0
A two-faced protein enables RNA-mediated DNA repair
2
0
Life and death predicted by DNA methylation
3
0
Behavioral Immune System model
4
0
Theorists can’t understand biology
6
0
Neuroplasticity
4
0
Receptor methylation controls behavior
2
0
Models are not theories (2)
2
0
Fossils vs cell types and the brain
3
0
Unraveling the secrets of RNA-mediated events
2
0
Designing, engineering, and protecting biodiversity
3
0
The virome, microbiome, replisome and supercoiled DNA
2
0
Skip the politics; embrace the facts
5
0
700 million years of evolution?
5
0
Biophysically constrained or unconstrained?
2
0
Mutated mitochondrial genes vs Supercoiled DNA
2
0
RNA-mediated retrotransposon-mediated biodiversity
3
0
Mystery machine vs model (2)
2
0
Preventing genomic entropy
4
0
Energy and evolution: another opinion?
2
0
Supercoiled DNA constrains virus-driven genomic entropy
2
0
Let there be anti-entropic light (2)
4
0
Foundamentals of theory
4
0
Microbes to humans 2015 Nobel Prize
2
0
Non-mainstream scientist shares Nobel prize in Medicine
3
0
Is mainstream science in “Science” pseudoscience?
5
0
Mechanisms of stress: from genes to cancer
9
0
Viruses come alive: Tree of life pseudoscience
6
0
Theorists have not seen the light (2)
3
0
Hijacked light energy and vertebrate pathology
4
0
Theorists have not seen the light
4
0
Alternative pre-mRNA splicing and ecological adaptation
7
0
Pathology: Eating and breathing viruses
2
0
Exosomes and the RNA-mediated future of medicine
5
0
Somatic hypermutation vs RNA-mediated events
2
0
Phytochemical link from the sun to cell types
2
0
Genome sequencing, cadherins, and quantum consciousness
6
0
“New” quantum biology. Pirating the old
3
0
Cell types, SNVs, CNVs, and chromosomes
3
0
Thermotolerance and Longevity
57
0
Is life the balance between quantum and classical physics?
3
0
Anti-entropic containment of energy: symbiosis 1.0
5
0
Information and communication (2)
6
0
Information and communication
2
0
From “Blood Music” to Evolution 2.0
5
0
Olfaction & the octopus and human genomes (2)
4
0
Olfaction & the octopus and human genomes
3
0
Thermodynamic constraints did not evolve
3
0
Mammalian-wide interspersed repeats (MIRs)
2
0
Ecological speciation vs revised evolutionary syntheses
6
0
Ecology replaces the extended evolutionary synthesis
4
0
The stability of organized genomes (4)
3
0
The stability of organized genomes (3)
3
0
Epimutation.com: a domain of confusion
8
0
Light -induced nucleic acid-mediated gene duplication?
< 1
0
Viruses, amino acids, and somatic cell types (2)
5
0
RNA-mediated terms of virus-induced en-deer-ment
2
0
Domestication via a single amino acid substitution
2
0
Becoming biologically informed (3)
3
0
Easy editing: Reinventing our RNA world
3
0
Is photic-zone ribosomal diversity linked to all biodiversity?
2
0
Picornaviruses moving between primates (or not)
2
0
Faithfully repaired DNA
5
0
RNA-mediated gene duplication, fixation, and ecological adaptation
6
0
MicroRNA controlled growth and brain development
7
0
MicroRNA – controlled ecological adaptations
5
0
Becoming biologically informed
2
0
Celebrating independence from ridiculous theories
3
0
Is SUMOylation RNA-directed DNA methylation? (revisited)
4
0
“New” epigenetic mechanism for lifelong learning?
3
0
The sum of our RNA-mediated parts
2
0
Protein folding and Google page rank
2
0
Iron, ferritin, thyroxine
2
0
Virus-driven death by evolutionary theory
3
0
“Evolution” of sex differences?
2
0
Nutrient stress-induced RNA-mediated pathology
< 1
0
Amino acid substitutions are not mutations
2
0
What I cannot create I eliminate from discussion
3
0
Creating and maintaining the human virome
2
0
Healthy mutants
2
0
Uniquely epigenomic gene regulation
2
0
Alternative splicings: epigenetics meets pharmacogenomics
4
0
Epigenetic regulation of aging by glycine and GnRH
5
0
Physicians who practice evolutionary medicine?
3
0
Pattern recognition: biogeochemical structure and function
5
0
Viruses and the human-like microbiome
3
0
Informing the biologically uninformed
< 1
0
I forgot. How do mutations cause evolution?
4
0
One amino acid substitution, genes, and brain activity
3
0
Batch effect vs epigenetic effects
3
0
Gene expression, immortality, and cancer
6
0
Scientists lose. A sci-fi author gains credibility
2
0
Vitamin B3 and DNA repair
4
0
Bees and primates automagically evolve
3
0
Ignoring systems complexity (it’s too complicated)
3
0
Virus-driven cancer treatment and prevention
2
0
The microbiome, pharmacogenetics, and privacy
< 1
0
A special issue on nutritional epigenetics
5
0
Retinoic acid + one receptor regulate the genome
3
0
Epigenetics: microRNAs effect an integrative pathway
4
0
Protein isoforms do not evolve
3
0
Tissue type variation and expression of genes
< 1
0
From gut bacteria to breast milk and back
5
0
Chance mutations — not natural selection
5
0
Viruses in gut microbes
4
0
How to find a “holy grail” under your nose
3
0
Physics, chemistry, light, and life
2
0
An epigenetic mark links algae, worms, and flies
2
0
Effect and affect of a single base-pair change
4
0
Thermodynamics and protein folding landscapes
2
0
Pathology constrains X-linked evolution
2
0
Feedback loops link insects to human brains
2
0
Viruses and cell type differentiation
3
0
RNA-mediated cell types and precision medicine
5
0
DNA Methylation and organized genomes
7
0
Misunderstanding cancer
7
0
Nutrient-dependent RNA interference (2)
4
0
Mutisensory integration: watching the paradigm shift
12
0
Origin of life and cancer (1,2,3)
2
0
Silencing genes and serious scientists
3
0
The miRNA/mRNA balance: a suboptimal strategy?
2
0
Nutrient-dependent microRNAs control cell types
6
0
Too many targets for theories
3
0
Methylation maintains cell type differences (2)
2
0
Creating nothing but a theory (3)
4
3
Creating nothing but a theory (2)
4
0
The quantum / classical RNA-mediated ‘tipping point’
3
0
Epigenetic switch links MicroRNAs to RNA-protein interactions
4
0
Quantum correlations/pseudoscience
3
0
Anti-entropic solar energy
5
0
Correctly modeling ecological adaptation
4
0
Is DNA-directed transcription RNA-mediated?
2
0
RNA directed DNA methylation and cell types
4
0
From 3-D to epigenetically-effected 4-D genome make-up
5
0
Biological energy and a microbiome model of a light-driven time machine
3
0
Quantum Superpositions: let there be light
4
0
Eliminating correlations from evolutionary ecology
6
0
Different physical locations and different molecular mechanisms of health and disease
2
0
Ecological variation and niche construction: 1, 2, 3
6
0
Memory of repression and memory of behavior (2)
< 1
0
Insect homology and diversity attributed to mutations
2
0
Comparing divergent model organisms
2
1
(click to enlarge)