MicroRNA-mediated population control (7)

By: James V. Kohl | Published on: August 6, 2021

Quantum coherence was linked across kingdoms to coherently organized biology in MicroRNAs organize intrinsic variation into stem cell states and via the STEM toy for ages 14+ Genotype.
Every fact that links quantum coherence to coherently organized biology via the energy-dependent structural diversity of supercoiled DNA and microRNA-mediated stem cell Creation via RNA interference () was replaced by claims of cryptic transcription in mammals.
See: Altered chromatin states drive cryptic transcription in aging mammalian stem cells 8/2/21

We show that cryptic transcription is elevated in aged mammalian stem cells, including murine hematopoietic and neural stem cells and human mesenchymal stem cells.

The claim about cryptic transcription can be linked to claims made by by foolish theorists about ecologically relevant “magic traits.” See: Genetic dissection of assortative mating behavior 2/7/19

Ecologically relevant mating cues (sometimes known as “magic traits” [2,6]) are now predicted to be widespread in nature [6,7], and the last few years have seen considerable progress in our understanding of their genetic basis.

See also:  Core promoter activity contributes to chromatin-based regulation of internal cryptic promoters 7/28/21

During RNA polymerase II (RNA Pol II) transcription, the chromatin structure undergoes dynamic changes, including opening and closing of the nucleosome to enhance transcription elongation and fidelity. These changes are mediated by transcription elongation factors, including Spt6, the FACT complex, and the Set2-Rpd3S HDAC pathway. These factors not only contribute to RNA Pol II elongation, reset the repressive chromatin structures after RNA Pol II has passed, thereby inhibiting aberrant transcription initiation from the internal cryptic promoters within gene bodies.

Cryptic promoters, cryptic transciption, and magic traits are not discussed by intelligent serious scientists in the context of energy-dependent autophagy, which requires dynamic changes that including opening and closing of the nucleosome to enhance transcription elongation and fidelity.
Intelligent serious scientists recognize the fact that claims about internal cryptic promoters within gene bodies are claims about the energy-dependent Creation of pH-dependent endogenous substrates that biophysically constrain cell type differentiation across kingdoms in the context of viral replication via autophagy.
For facts about biophysically constrained cell type differentiation across kingdoms, see: MicroRNA Involvement in Signaling Pathways During Viral Infection 3/10/20

Though scientists are far from completely understanding all the molecular mechanisms behind the complex cross-talks between miRNA pathways and viral infections, the general knowledge is increasing on the different roles played by miRNAs during viral infections.

See also: Diet-derived transmission of MicroRNAs from host plant into honey bee Midgut 8/3/21

…based on the findings of present study, it is suggested that the probability of plant miRNAs being transferred from nurse bees to larvae during feeding be explored further in the future.

and Nutrient-dependent/pheromone-controlled adaptive evolution: a model 6/14/13

An environmental drive evolved from that of nutrient ingestion in unicellular organisms to that of pheromone-controlled socialization in insects. In mammals, food odors and pheromones cause changes in hormones such as LH, which has developmental affects on pheromone-controlled sexual behavior in nutrient-dependent reproductively fit individuals across species of vertebrates.

…the epigenetic ‘tweaking’ of the immense gene networks that occurs via exposure to nutrient chemicals and pheromones can now be modeled in the context of the microRNA/messenger RNA balance, receptor-mediated intracellular signaling, and the stochastic gene expression required for nutrient-dependent pheromone-controlled adaptive evolution. The role of the microRNA/messenger RNA balance (Breen, Kemena, Vlasov, Notredame, & Kondrashov, ; Duvarci, Nader, & LeDoux, ; Griggs et al., ; Monahan & Lomvardas, ) in adaptive evolution will certainly be discussed in published works that will follow.

Apparently, the missing link from what organisms eat to the physiology of reproduction stayed missing from 6/14/13 to 8/3/21?
Perhaps the problem was linked to mathematical models that failed to start with energy-dependent microRNA-mediated viral latency. That may be why the mathematical models touted by theorists did not make sense to intelligent serious scientists. All intelligent serious scientists learned that the differences between environmental drives that evolved and ecological adaptations. Simply put, light-activated carbon fixation since been linked to the patent for naturally occurring protonated RNA interference and biophysically constrained viral latency across kingdoms.
See: RNA-Guided Human Genome Engineering
What will pseudoscientists, atheists, Communists and other theorists do now that mathematical models have been linked from quantum coherence to coherently organized biology via microRNA-disease associations?
See: Identification of miRNA-disease associations via multiple information integration with Bayesian ranking 8/4/21

To improve the efficiency of miRNA–disease association discovery, some calculation methods were developed as auxiliary tools for researchers. In the current study, we raised a novel model named Bayesian Ranking for MiRNA–Disease Association prediction (BRMDA) by improving Bayesian Personalized Ranking from three aspects: (i) taking advantage of similarity of diseases and miRNAs; (ii) incorporating miRNA bias for miRNAs associated with different number of diseases; and (iii) implementing neighborhood-based approach for new miRNAs and diseases.

See also: Identification of potential biomarkers in dengue via integrated bioinformatic analysis 8/4/21

…our study displayed the effectiveness of bioinformatics analysis methods in screening potential pathogenic genes in dengue fever and their underlying mechanisms.

And see:
An Overview of Mesenchymal Stem Cell-based Therapy Mediated by Noncoding RNAs in the Treatment of Neurodegenerative Diseases 8/4/21

…we summarize the potential role and regulatory mechanism of two major types of ncRNAs, including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), during the neurogenesis of MSCs with gene expression profile analyses. We also overview the realization of MSC-based therapy mediated by ncRNAs in the treatment of spinal cord injury, stroke, Alzheimer’s disease and peripheral nerve injury.

Former President Trump and intelligent serious scientists who followed his lead finally have linked light-activated biophysically constrained pH-dependent microRNA-mediated RNA interference () and fixation of amino acid substitutions in organized genomes to God’s microRNA-mediated future of humanity (the 10-part series was completed on 5/10/20).
How many theorists were stupid enough to ridicule former President Trump for this claim from 4/23/20:

President Donald Trump touted a federal study Thursday that indicates sunlight and humidity can weaken the coronavirus – a finding that prompted the president to float the idea of treating patients with “light inside the body.”

Peptide synthesis at the origin of life 11/13/20 was linked to treatment with light inside the body via Visualizing a protonated RNA state that modulates microRNA-21 maturation 10/26/20, which appeared first as a preprint on 11/23/19

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