Natural selection for adaptation (3)

By: James V. Kohl | Published on: August 23, 2021

See: Natural selection for adaptation (2)

Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths 8/19/21

Senior author Jean-Laurent Casanova‘s claims have consistently linked energy-dependent biophysically constrained viral latency across kingdoms. They can be linked to prevention of unnecessary suffering and premature COVID-19 deaths via my 10-part series on microRNA-mediated replication.
Facts about microRNA-mediated replication were presciently placed into the context of healthy longevity via refutations of stupid theories by researchers from the Rockefeller Institute in 1964.
See: Biology, molecular and organismic
See also: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation”
Fifty-six years later, you can see also: MicroRNAs organize intrinsic variation into stem cell states 3/5/20 and MicroRNA Involvement in Signaling Pathways During Viral Infection 3/10/20
Summary: All intelligent serious scientists have since linked oxidative phosphorylation to biophysically constrained viral latency across kingdoms. Theorists ignored all the experimental evidence of cause and effect.
For example of what’s been ignored, see the works of David M. Sabatini, which include links from oxidative phosphorylation to RNA interference (RNAi) such as: Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides. 4/3/14

Sensitivity to low glucose varies amongst cell lines, and an RNA interference (RNAi) screen pinpointed mitochondrial oxidative phosphorylation (OXPHOS) as the major pathway required for optimal proliferation…

For comparison to everything known to intelligent serious scientists about oxidative phosphorylation and RNA interference, see: Mammalian retrovirus-like protein PEG10 packages its own mRNA and can be pseudotyped for mRNA delivery 8/20/21
Senior co-authors Eugene V. Koonin and Feng Zhang’s claims have been linked from microRNA-mediated prevention of the virus-driven degradation of mRNA to biophysically constrained healthy longevity via human endogenous retroviruses (HERVs). But their most recent claims have not been linked to anything known about energy-dependent constraints on RNA-mediated fixation of amino acid substitutions in organized genomes.

Instead, they link an “…endogenous fusogenic transmembrane protein” to the creation of Human Endogenous Retroviruses (HERVs).

If David M. Sabatini was dead and buried, he would be turning over in his grave. Instead he has reportedly been charged with sexual harassment.
MIT professor, biotech founder placed on leave following investigation into sexual harassment 8/20/21

“In sum, the investigation found that Dr. Sabatini violated the Institute’s policies on sexual harassment among other Whitehead policies…

My investigation of sexual harassment charges brought against me by hospital administrator, Shawn Wiscombe led me to find that he promised a female lab trainee, Linda Bond continued employment if she claimed that accidentally brushing against her breasts was an act of sexual harassment.  He was angry with me because I would not agree to perform saliva alcohol testing in the lab. (The test kit was substandard, and the Medical Director did not believe the harassment charges).

HHMI fires prominent biologist for sexual harassment 8/21/21

“…the firing will have “significant implications” for the 39 people who worked in the Sabatini lab, which focuses on the mechanisms that regulate growth and metabolism in mammals. All 39 will be meeting with Whitehead human resources personnel next week, she wrote, with the aim of transitioning them smoothly to other situations.”

A clear message was sent to anyone who might otherwise be willing to follow up on:  Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex 2/18/05

The rictor-mTOR complex directly phosphorylated Akt/PKB on Ser473 in vitro and facilitated Thr308 phosphorylation by PDK1.

Attempts to link that fact to drug therapies, or from food energy-dependent pheromone-regulated genetic processes to ecological adaptations via RNA interference will continue to be thwarted by the same people responsible for the charges against Sabatini.  Who are they?
All stupid theorists and profiteers who know how viral latency is biophysically constrained share the same reasons for not wanting others to learn the scientific truth about RNA-guided human genome engineering. It is naturally occurring.
Attempts to profit from God’s naturally occurring genetic processes of light-activated carbon fixation and biophysically constrained viral latency would not be allowed if more people linked God’s Creation of sunlight and humidity to oxygen-dependent plant growth and all life on Earth via what organisms eat and their physiology of reproduction — as detailed for a general audience of non-scientists in Biblical Genesis.

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