Natural selection for adaptation (8)

By: James V. Kohl | Published on: September 2, 2021

Facts about natural selection for adaptation can be compared to theories of Evolution by Gene Duplication (1970)

The creation of metazoans, vertebrates and finally mammals from unicellular organisms… required the creation of new gene loci with previously nonexistent functions.

The persistent theories of evolution by gene duplication can be compared to facts natural selection for adaptation in the context of God’s Creation of subatomic particles, such as protons and the ATP-dependent creation of RNA, which was required to link the energy-dependent Creation of new gene loci to pH-dependent biophysically constrained viral latency via oxidative phosphorylation and protonated RNA interference (RNAi) via the physiology of pheromone-regulated genetic processes of reproduction in species from cyanobacteria to humans.
Stupid theories are much easier for biologically uninformed theorists to accept compared to the experimental evidence that links RNAi to proton therapy for cancer. Simply put, the links to proton therapy/proton beam therapy require God’s Creation of protons and the ATP-dependent synthesis of RNA. No ecologically relevant “magic traits” were required.
If you prefer to start with “magic traits” see: Genetic dissection of assortative mating behavior 2/7/19

Ecologically relevant mating cues (sometimes known as “magic traits” [2,6]) are now predicted to be widespread in nature [6,7], and the last few years have seen considerable progress in our understanding of their genetic basis.

See for comparison: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation”(1964)

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

Start with God’s Creation of subatomic particles and ATP-dependent RNA synthesis, and learn how Defective satellite DNA clustering into chromocenters underlies hybrid incompatibility in Drosophila 7/24/21
It was reported as So-called “junk” DNA plays a key role in speciation 8/20/21

…the researchers decided to focus on two branches of the fruit fly family tree: the classic lab model Drosophila melanogaster, and its closest relative, Drosophila simulans. These two species diverged from each other two to three million years ago.

No experimental evidence of biologically-based cause and effect suggests any species diverged from any other species during two to three million years of evolution. For contrast, in 1910, Thomas Hunt Morgan linked nutrient-dependent pheromone-regulated genetic processes of reproduction to chromosomal rearrangements and sympatric speciation in flies, and the claims have since been extended across species to prevention of virus-driven pathology, such as cancer.
See: The miR-200 family in normal mammary gland development 8/28/21 and Association between single-nucleotide polymorphisms in miRNA and breast cancer risk: an updated review 8/28/21

Single-nucleotide polymorphisms (SNPs) in microRNA (miRNA) genes have recently been identified as BC risk factors.

The SNPs rs2910164 (miRNA-146a), rs11614913 (miRNA-196a2), rs3746444 (miRNA-499) and rs6505162 (miRNA-423) were the most widely associated with increased BC risk; (e) The majority of studies had small samples, which may affect the precision and power of the results; and (f) The effect of an SNP on BC risk depends on the ethnicity of the population.

The facts about SNPs in microRNA genes and non-pathological mammary gland development loosely fit into the context of Environmental selection during the last ice age on the mother-to-infant transmission of vitamin D and fatty acids through breast milk 4/23/18

The frequency of the human-specific EDAR V370A allele appears to be uniquely elevated in North and East Asian and New World populations due to a bout of positive selection likely to have occurred circa 20,000 y ago.

EDAR V370A is a SNP in the ectodysplasin A receptor EDAR gene on chromosome 2. It is also known as rs3827760, 1540T/C, 370A or Val370Ala.
A better fit with facts about how rs3827760 and other SNPs in microRNA genes biophysical constrain viral latency was established in Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants 11/28/12 reported as: Past 5,000 years prolific for changes to human genome

The findings confirm their earlier work suggesting that the majority of variants, including potentially harmful ones, were picked up during the past 5,000–10,000 years.

How many food energy-dependent pheromone-regulated SNPs in microRNA genes such as the SNP, rs3827760 are required to protect you and your loved ones from unnecessary suffering and premature death?
See also: MicroRNA: A mediator of diet-induced cardiovascular protection

…diet-induced cardioprotection may result from the synergistic effects from both the modulation of endogenous and exogenous miRNAs (Figure 1).

Compare their Figure 1 to my Figure 1 from Nutrient-dependent/pheromone-controlled adaptive evolution: a model (2013)
Figure 1
An external file that holds a picture, illustration, etc. Object name is SNP-3-20553-g001.jpg
See also the diagram from What is life when it is not protected from virus driven entropy (2016).

It was published as:  Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems (2018)
No other model of biophysically constrained life on Earth can be discussed in the context of this report on  Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths 8/19/21
See:  Rogue antibodies involved in almost one-fifth of COVID deaths 8/31/21
If the virus-driven degradation of messenger RNA is not the link from the accumulation of rogue antibodies to COVID deaths, there is no explanation for everything known to intelligent serious scientists about the energy-dependent microRNA-mediated prevention of diseases across kingdoms.

Notify of
Inline Feedbacks
View all comments

Want more on the same topic?

Swipe/Drag Left and Right To Browse Related Posts: