Naturally attenuated viral endemicity (3)
(click to enlarge)
See first: Naturally attenuated viral endemicity (2) peptide synthesis at the origin of life and single nucleotide polymorphisms (SNPs) in microRNAs.Spatiotemporal regulation and roles of reproductive phasiRNAs in plants 11/11/21
…co-suppression was discovered as a pioneer silencing phenomenon of RNA interference (RNAi) in petunia in 1990…
President Joe Biden’s scientific advisor, Eric Lander linked the facts about co-suppression and RNAi in petunias from biophysically constrained viral latency in plants to healthy longevity in humans in this 2012 representation of light-activated microRNA-mediated cause and effect.VIDEO RNA-Guided Human Genome Engineering
5. Repetitive elements or endogenous viral elements can be targeted with engineered Cas+gRNA systems in microbes, plants, animals, or human cells to reduce deleterious transposition or to aid in sequencing or other analytic genomic/transcriptomic/proteomic/diagnostic tools (in which nearly identical copies can be problematic).
The fact that energy-dependent RNAi biophysically constrains endogenous viral elements / human endogenous retroviruses (HERVs), which are reactivated by nutrient stress or social stress, can be examined in the context of a recent publication that was co-authored by George M. Church in collaboration with researchers from China.Regulation of host and virus genes by neuronal miR-138 favours herpes simplex virus 1 latency 2/8/21
In summary, miR-138 targets ICP0, Oct-1 and Foxc1 to repress HSV-1 lytic cycle genes and promote epigenetic gene silencing, which together enable favourable conditions for latent infection.
Latent infection is biophysically constrained viral latency manifested in the context of HERVs. The importance of HERVs can be linked to the importance of biophysically constrained endogenous retroviruses in all other species. But, if you want to keep the focus on humans, see:MicroRNA-376b-3p Promotes Porcine Reproductive and Respiratory Syndrome Virus Replication by Targeting Viral Restriction Factor TRIM22 11/10/21
TRIM22 has recently been identified as a key restriction factor that inhibited the replication of a number of human virus such as HIV, ECMV, HCV, HBV, IAV, and RSV.
Any intelligent serious scientist who has not yet publicly linked light-activated carbon fixation to inhibited replication of all viruses and HERVs across kingdoms via pattern recognition in the context of RNAi is a fool or a liar.Get Well in the RNAi Way-RNAi, A Billion Dollar Baby in Therapy
RNAi has targeted exogenous genes in models of viral infection…
The importance of this therapy cannot be overestimated. It can be linked to my 10-part series on the microRNA-mediated future of humanity.
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4
0
Automagical protein creation sans energy
9
0
Pattern recognition vs evolutionary processes (revisited)
7
0
Energy-dependent physical and biophysical constraints (9)
3
0
Energy-dependent physical and biophysical constraints (3)
2
0
Cell type assembly and the space-time continuum
2
0
Epigenetic effects of stress by Bruce McEwen (2)
3
0
The emergence of light as energy from a life-giving star (2)
2
0
God’s shrinking role in salvation (3)
9
0
God's shrinking role in salvation (3)
9
0
Food energy-dependent cell type differentiation (2)
10
0
Hard Science vs the neo-Darwinian “magic box”
9
0
Infections and age change the odor of wine and people
4
0
From E. coli to monkeys and mankind: Theories vs models (4)
2
0
Food energy-dependent epigenetic adaptation (2)
< 1
0
Food energy-dependent epigenetic adaptation
11
0
Cytosis in the light of evolution
5
0
Energy-dependent epigenetic translation to mRNA stability
8
0
Energy as information and constrained endogenous RNA interference (4)
7
0
What energy source do proteins prefer?
6
0
Draining the academic swamp of parasites
3
0
The death of CRISPR; long live endogenous RNAi
5
0
Feng Zhang refutes theistic evolution
4
0
Open Science: Closed to facts about microRNAs
6
0
Viruses in pathogenic variants disrupt alternative splicings
2
0
Respiration-dependent endogenous RNA interference
4
0
Epigenetically-effected nucleosome repositioning sheds Dobzhansky’s light on evolution
3
0
Synthetic RNA-based switches
2
0
Functionally interdependent editing and methylation
4
0
Cytosis: Biology Content
7
0
Light-activated feedback loops vs self-organization of ecosystems
7
0
Cytosis: A Cell Biology Board Game
< 1
0
Food for thought: Penrose v Ellis (1)
5
0
Magnussen’s “Faith fools” keep the faith
3
0
Energy-dependent pheromone-controlled entropy (4)
3
0
Sunlight: the essence of precision medicine and world peace
6
0
The essence of precision medicine: drug targets or healthy longevity?
4
0
Ab initio cell wall invention, emergence, and evolution (2)
8
0
RNA-mediated adult learning, memory, and neurogenesis
3
0
Energy-dependent allelic imbalances, viruses, and pathology
3
0
Ab initio cell wall invention, emergence, and evolution (1)
2
0
Biologically uninformed biologists fight back and lose
3
0
Theistic evolutionists fight back and lose (3)
4
0
Theistic evolutionists fight back and lose
4
0
Young earth creationists refute theistic evolution
3
0
Bill Gates refutes theistic evolution (prequel)
2
0
Bill Gates refutes theistic evolution (sequel)
8
0
Bill Gates refutes theistic evolution
4
0
Emily Witkin refutes theistic evolution
2
0
RNA editing refutes theistic evolution
4
0
Pseudoscientists fail to refute theistic evolution
4
0
Francis S. Collins refutes theistic evolution
6
0
Energy is information. Objections over ruled. You’re fired!
7
0
Happy Darwin Day (2017)
4
0
George Church refutes theistic evolution (3)
5
0
George Church refutes theistic evolution (2)
2
0
George Church refutes theistic evolution
5
0
Physicists: Desperate Acts (revisited)
6
0
Energy as information and constrained endogenous RNA interference (3)
4
0
Virus-driven energy theft and premature death
3
0
Fighting for virus-driven pathology
5
0
Dobzhansky 1973 and precision medicine (5)
3
0
Atomic theory vs facts about hydrogen-atom transfer
4
0
Dobzhansky 1973 and precision medicine
6
0
Twisted theories and weaponized facts
3
0
Autophagy: from pre-mRNAs to microRNAs, enhancers, QTLs et al.
6
0
Mutations: the “driving force” behind human brain complexity?
6
0
Mutations: the "driving force" behind human brain complexity?
6
0
Critical values expose virus-driven energy theft (2)
4
0
Theorists sell hidden energy (2)
4
0
Critical values expose virus-driven energy theft
6
0
Theorists sell hidden energy
3
0
Evolved patterns of brain stimulation
3
0
Chirality is reality
6
0
Energy-dependent hydrogen bonds in supercoiled DNA
7
0
Energy-dependent chirality
6
0
Energy-dependent alternative splicings 1996 – 2016 (2)
5
0
Vietnam Veterans and others with glioblastoma
3
0
Energy-dependent sensory maps (1996-2016)
5
0
Energy-dependent alternative splicings 1996 – 2016
12
0
Energy-dependent oscillating gene networks organize life
4
0
2016 obfuscated facts about energy as information
5
0
More refutations of neo-Darwinian nonsense
7
0
Re-inventing mutation-driven evolution (2)
4
0
Sudden death indel polymorphism
4
0
Anti-entropic virucidal energy as information
10
0
Energy-dependent natural translational selection
4
0
Tasting light links energy from creation to adaptation
9
0
Combating evolution: Battlefield medicine vs politicized science
6
0
The futility of The Battlefield FB group
10
0
Metabolic Phenotyping Research
2
0
Phylogenetic similarity sans energy
2
0
Happy biophysically constrained Thanksgiving (in the USA)
3
0
De novo gene creation: Ignoring the experimental evidence
7
0
Energy-dependent coulombic, autophagic, polycombic healthy longevity
4
0
Light, behavior and autophagy, a gender-specific risk factor
4
0
Controlled amino acid treatment of all pathology
4
0
Energy-dependent purifying selection / autophagy (3)
2
0
Energy-dependent purifying selection / autophagy (6)
3
0
Optogenetics: Let there be virucidal light!
2
0
Base pairs, amino acids and phenotypes
10
0
Survivors of RNA-mediated terrorism
5
0
Building delicious base pairs in class. It’s elementary Watson and Crick
3
0
Building delicious base pairs in class. It's elementary Watson and Crick
3
0
Epigenetically effected energy-dependent fluorescence
5
0
Epigenetics and autophagy vs mutations and evolution (4)
< 1
0
Coulombic interactions facilitate polycombic adaptation
5
0
Top-down adaptation vs bottom-up evolution
6
0
Polycombic ecological adaptation as a science, not a theory (2)
12
0
Polycombic ecological adaptation as a science, not a theory
3
0
80 years of causal analysis (1936 – 2016)
11
0
Did evolution autophosphorylate your kinases? (3)
2
1
The natural success of RNAi and failed treatment
7
0
Hecatombic evolution via oncocers and oncohistones
9
0
Life is energy-dependent task management
3
0
Hypothesis free pseudoscience vs facts (5)
6
0
The last RNA-mediated theory killer
< 1
0
Base pairs, olfaction and RNA thermometers
4
0
Chromatin: The structure of DNA
6
0
Consciousness is simply food rearranged
2
0
Hydrogen-atom energy in DNA base pairs
6
0
DNA repair via junk DNA (2)
5
0
The Aquatic Ape / Waterside Ape divergence
6
0
Light energy-dependent active motifs
6
0
Light energy-induced base pair changes (2)
4
0
Light energy-induced base pair changes (1)
6
0
Displays of ecological adaptation
2
0
Virus-driven energy theft causes cancer
2
0
How did the innate immune system evolve?
4
0
Plant microRNAs slow virus-driven aging
3
0
Increased soil pH and nutrient availability
4
0
Virus-driven energy theft: honeybee model
3
0
Antithetical conclusions (7)
3
0
Anthetical conclusions
3
0
RNAi: From magic bullet to billion dollar baby
4
0
Co-evolution and co-speciation replace neo-Darwinian nonsense
4
0
Pseudoscientists ignore what serious scientists prove
6
0
Food supplement or licensed immunostimulant?
6
0
Virus-driven downsizing of the human brain (3)
4
0
Biophotonics, glycobiology, quantized biodiversity (2)
19
0
The end of neo-Darwinism
5
0
Biophotonics, glycobiology, quantized biodiversity
4
0
The Origin of Information (2)
6
0
The Origin of Information (1)
6
0
Light ‘drives’ adaptation; nothing ‘drives’ evolution
6
0
Funding the Human Genome Project-Write
2
0
RNA-mediated programming of E.coli
< 1
0
Virus-driven downsizing of the human brain (2)
< 1
0
Virus-driven downsizing of the human brain
2
0
MicroRNAs and sexual orientation
8
0
Innate immunity and multiplexing
7
0
Amino acids and virus penetration
3
0
Masters of deception about nature (2)
7
0
The Mind’s Eyes (revisited)
10
0
Cracking the Olfactory Code?
5
0
RNA methylation, behavior, and disease
6
0
Energy-dependent RNA methylation (10)
4
0
Energy-dependent RNA methylation (8)
4
0
Energy-dependent RNA methylation (7)
7
0
Energy-dependent RNA methylation (5)
3
0
Energy-dependent RNA methylation (3)
10
0
Energy-dependent RNA methylation (2)
5
0
Energy-dependent RNA methylation (1)
6
0
Secular humanism and ecoterrorism
4
0
War Games: False Flag Terrorism
5
0
Energy-dependent biodiversity (2)
2
0
The tipping point? 50,000 publications (3)
6
0
Neo-Darwinism failed in 1995
3
0
Countdown to Genetics and Genomics
< 1
0
Energy-dependent creation and entropy
4
0
RNA-mediated physics, chemistry, and molecular epigenetics (4)
5
0
RNA-mediated physics, chemistry, and molecular epigenetics (3)
5
0
RNA-mediated physics, chemistry, and molecular epigenetics
9
0
RNA splicing, genetic variation, and disease
2
0
Wasted Templeton Funding (3)
2
0
Wasted Templeton Funding (2)
2
0
Millions of water molecules vs years of evolution
2
0
A bumper crop of virus-infected weeds and people
2
0
Molecular Diagnostics: What is unprotected life (4)
2
0
Molecular Diagnostics: What is unprotected life (3)
5
0
Molecular Microbial Ecology
8
0
Molecular Diagnostics: What is unprotected life? (2)
7
0
Molecular Diagnostics: What is unprotected life?
2
0
Creating and/or programming the immune system
< 1
0
Half truths support theories without facts
4
0
Ricki Lewis’ Time Machine (3)
5
0
Creating nutrient-dependent life with enough genes to survive
3
0
Confusing effects and affects of visual input
2
0
Selective reporting of inferences: examples of pseudoscience
14
0
Ignore the evidence: Rachel Feltman
5
0
Virus-driven disorder prevention and health promotion
6
0
Stress-linked population-level history dependence
5
0
Do not miss the misrepresentations
2
0
Energy dependent RNA-mediated immunity (3)
8
0
RNA-mediated DNA modifications
5
0
Science vs semantics
4
0
From angstroms to ecosystems and entropy
2
0
Bacteria see the light and they adapt (2)
5
0
Soil bacteria, bulls, cows, microRNAs, and mammary glands (2)
3
0
Soil bacteria, bulls, cows, microRNAs, and mammary glands
3
0
Effects on invertebrate GnRH and affects on primate behavior
6
0
Creating gravity, nucleic acids, receptors, and supercoiled DNA
2
0
Hydrogen-atom transfer in DNA base pairs (7)
5
0
Organic Compounds and the Miracle of Smell and Taste
7
0
Neuroscience Virtual Event vs AAAS Symposium
3
0
Cancer: Evolution 2.0’s Blind Spot
13
0
Ricki Lewis’ Time Machine (2)
6
0
Blood test links atoms to ecosystems
2
0
Teleophobes vs teleophiles: a recent history
2
0
Ecological genomics: teleophobes respond (too late)
10
0
Genes, orchid odors, and pheromones from blonds
5
0
Amino acid substitutions, stress, and human behavior
3
0
RNA methylation, RNA-directed DNA methylation, learning and memory
3
0
Finding peace and π in the light of H bond energy
5
0
Assumptions prove ignorance (2)
5
0
Epigenetic (re)programming of behavior
4
0
Assumptions prove ignorance
5
0
Neo-Darwinian sink testing
2
0
NORAD: air defense and defense against genomic entropy
7
0
Life history transitions and RNA-mediated survial
2
0
Did Dobzhansky see the UV light of creation?
10
0
RNA-mediated theory killers (6) (7) (8) (9) (10)
5
0
Manufacturing fossil “evidence”
4
0
RNA-mediated theory killers (4)
9
0
RNA-mediated theory killers (5)
2
0
RNA-mediated theory killers (3)
7
0
RNA-mediated regulatory mechanisms link microbes to humans (3)
5
0
RNA-mediated theory killers
6
0
Natural cooperation and Evolution 2.0
6
0
A two-faced protein enables RNA-mediated DNA repair (3)
8
0
Organization of biological sequences
2
0
Virally derived RNA molecules and cell types
2
0
Positive feedback loops and epigenetic traps
2
0
Stress-perturbed mitochondrial dysfunction (2)
5
0
Behavioral Immune System model
4
0
Stress-perturbed mitochondrial dysfunction
4
0
Sensationalizing no new mechanism
2
0
Too complex for the Complex Biological Systems Alliance
4
0
Receptor methylation controls behavior
2
0
Virus, transposon and plasmid evolution
< 1
0
Models are not theories (2)
2
0
Models are not theories (1)
2
0
Can veterans and other prisoners escape pseudoscience?
2
0
Unraveling the secrets of RNA-mediated events
2
0
Ecological speciation. Get it, theorists?
< 1
0
Designing, engineering, and protecting biodiversity
3
0
The virome, microbiome, replisome and supercoiled DNA
2
0
Skip the politics; embrace the facts
5
0
Neo-Darwinian logic is nonsense
3
0
FREE* SAMPLE: Histone modification
4
0
Biophysically constrained or unconstrained?
2
0
Mutated mitochondrial genes vs Supercoiled DNA
2
0
Mystery machine vs model
2
0
Mystery machine vs medical intelligence
2
0
Molecule of life vs animal experiments
< 1
0
Keep the gay gene theory?
< 1
0
Supercoiled DNA constrains virus-driven genomic entropy
2
0
Olfaction & the octopus and human genomes (2)
4
0
The stability of organized genomes (4)
3
0
Is SUMOylation RNA-directed DNA methylation? (revisited)
4
0
microRNAs, glycosylation, and genomes
4
0
Viruses in gut microbes
4
0
Pathology constrains X-linked evolution
2
0
An epigenetic trap (the prequel)
5
0
Nutritional epigenetics, exercise, and immune system integrity
4
0
RNA eclipses the importance of DNA to cell type differentiation
4
0
Pheromone-controlled thermodynamics and cancer
2
0
(click to enlarge)