microRNA-mediated cures (2)

By: James V. Kohl | Published on: December 2, 2021

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If you find a recently published article that does not link “How microRNAs control cell division, differentiation and death” (2005) to healthy longevity instead of virus-driven diseases, please share it for comparison to “Advances in Genetics: Chapter One – miRNA, Development and Disease (2012) and Human pheromones and food odors: epigenetic influences on the socioaffective nature of evolved behaviors (3/15/12).
Neo-Darwinian theorists and Big Bang cosmologists desperately need experimental evidence of energy-dependent top-down causation to support their stupid theories, and they are running out of time to find it.
See for comparison: Genetic variations creating microRNA target sites in the FXN 3′-UTR affect frataxin expression in Friedreich ataxia (1/30/13), Nutrient-dependent/pheromone-controlled adaptive evolution: a model (6/14/13), and the textbook-length pseudoscientific nonsense published on the same day: Mutation-Driven Evolution
For comparison to Genetic variations creating microRNA target sites…, and Nutrient-dependent/pheromone-controlled adaptive evolution, Masatoshi Nei claimed that nucleotide substitutions, insertion/deletion, segmental gene duplication, genomic duplication, changes in gene regulatory systems, transposition of genes, horizontal gene transfer et al., were mutations. His stupid claims linked natural selection to saved changes of genomic structure via advantageous mutations, but he eliminated harmful mutations based on the type of DNA change and DNA damage that must be repaired across kingdoms for species survival. Simply put, epigenetic effects on genes were linked from natural selection to an evolutionary process initiated by mutation.
But wait, all epigenetic effects are energy-dependent and microRNA-mediated. That fact does not fit any model of mutation-driven animal evolution. How did theorists arrive at the claims in: MirGeneDB 2.1: toward a complete sampling of all major animal phyla 11/25/21
It extends natural selection from an evolutionary process initiated by mutation to claims about ∼800 million years of animal evolution but the authors also link evolution to a total number of 16,670 microRNAs from 1549 families. Remember, the microRNAs do not automagically create themselves, and yet here we have a disparate claim that suggests they did during ~800 million years of mutation-driven evolution.
For comparison to the confusion associated with pseudoscientific nonsense, Alexandra Caude-Henrion’s group patented a bioinformatic tool, “MiRiFix.” It links light-activated energy-dependent changes from carbon fixation to single nucleotide polymorphisms (SNPs) in microRNAs, which links light-activated carbon fixation from microRNA biogenesis to patents linked to microRNA-mediated cures for all virus-driven diseases.
See for instance: RNA-Guided Human Genome Engineering

5. Repetitive elements or endogenous viral elements can be targeted with engineered Cas+gRNA systems in microbes, plants, animals, or human cells to reduce deleterious transposition…

The bioinformatic tool, MiRiFix already linked reduction of deleterious transpositions to healthy longevity across kingdoms. It was disingenuous for George M. Church to patent naturally occurring light-activated carbon fixation as if no one had already linked it from microRNA biogenesis to healthy longevity via a bioinformatic tool and Biblical Genesis.
But see also: miRTarBase update 2022: an informative resource for experimentally validated miRNA-target interactions 11/30/21

In recent years, the interaction between miRNAs and their target genes has become one of the mainstream directions for drug development. As a large-scale biological database that mainly provides miRNA–target interactions (MTIs) verified by biological experiments, miRTarBase has undergone five revisions and enhancements.

There would be no need for revisions and enhancement in the context of drug development, if all intelligent serious scientists started with God’s Creation of energy-as-information and linked experimental evidence of top-down causation to the claims from our award-winning 2001 review.
See: Human pheromones: integrating neuroendocrinology and ethology

The effect of sensory input on hormones is essential to any explanation of mammalian behavior, including aspects of physical attraction. The chemical signals we send have direct and developmental effects on hormone levels in other people. Since we don t know either if, or how, visual cues might have direct and developmental effects on hormone levels in other people, the biological basis for the development of visually perceived human physical attraction is currently somewhat questionable. In contrast, the biological basis for the development of physical attraction based on chemical signals is well detailed.

Since 2001, Olfaction Warps Visual Time Perception (2017) and Pheromone effects on the human hypothalamus in relation to sexual orientation and gender have linked Footprints of a Singular 22-Nucleotide RNA Ring at the Origin of Life 4/25/20 from Peptide synthesis at the origin of life 11/13/20 to Visualizing a protonated RNA state that modulates microRNA-21 maturation 10/26/20 and to healthy longevity or virus-driven pathology.
The facts exist whether you start with God’s Creation of energy, or with a mathematical model. However, if you start with a mathematical model, you exemplify human idiocy.