microRNA-mediated cures (9)
(click to enlarge)
Systematic Characterization of MicroRNA Processing Modes in Plants With Parallel Amplification of RNA Ends 12/7/21 links light-activated carbon fixation from the ATP-dependent creation of RNA and Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” (1964) to microRNA-mediated cures via this claim:
The synthesis of RNA in isolated thymus nuclei is ATP dependent.
Moving forward, The two-step process of ovarian follicular growth and maturation in mammals can be compared to a fruit ripening where quality depends on the second step 12/23/21
As long as FSH stimulates growth, follicles remain green, and it is only when FSH is replaced by LH that the ripening process begins, and “apples” become red. Both fruits, follicles and apples, depend on a perfect timing of events to generate offspring.
Here’s the model for that: Nutrient-dependent/pheromone-controlled adaptive evolution: a model (6/14/13)
An environmental drive evolved from that of nutrient ingestion in unicellular organisms to that of pheromone-controlled socialization in insects. In mammals, food odors and pheromones cause changes in hormones such as LH, which has developmental affects on pheromone-controlled sexual behavior in nutrient-dependent reproductively fit individuals across species of vertebrates.
Figure 1
My model is a refutation of neo-Darwinian nonsense. See Mutation-Driven Evolution, which was published on the same day. On page 136, Masatoshi Nei inadvertently linked what is known about God’s Creation of sunlight and humidity from energy-dependent light-activated carbon fixation to microRNA biogenesis and pH-dependent Peptide synthesis at the origin of life 11/13/20.
Nei’s spurious claims from 2013 can be linked to my claim about the biophysically constrained evolution of a food energy-dependent pheromone-regulated environmental drive. He then helped to clarified the fact that microRNAs control levels of protein production by degrading mRNAs, and linked the microRNA-mediated control to altered expression of phenotypes before claiming that all alterations of phenotypes arise in the context of mutations.
His idea of a mutation includes virtually anything that alters the functional structure of supercoiled DNA. For examples: single nucleotide substitutions, insertion/deletion, segmental gene duplication, genomic duplication, changes in gene regulatory systems, transposition of genes, and horizontal gene transfer.
Instead of linking natural selection for energy-dependent codon optimality to the perfect timing of events required to generate offspring across kingdoms, he claims that natural selection saves advantageous mutations and eliminates harmful mutations. “… therefore natural selection is an evolutionary process initiated by mutation.”
See for comparison: Crosstalk between codon optimality and cis-regulatory elements dictates mRNA stability 1/5/21, which was presciently placed into the context of facts in Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems 4/18/18
…pheromones appear to control the nutrient-dependent epigenetically-effected hormone-dependent organization and hormone-activation of reproductive sexual behavior in mammals such as mice and humans, but also in invertebrates and in microbes as previously indicated.
The ecological adaptations, which appear to be manifested in the human population are detailed in these two reports [159,160]. The ecological adaptations are likely to be nutrient-dependent and pheromone-controlled. If so, ecological variation probably leads to ecological, social, neurogenic, and socio-cognitive niche construction, which is manifested in increasing organismal complexity and species diversity. If not, there may be something as yet unknown about mutations and evolution that makes sense in the light of what is known about nutritional epigenetics and the molecular biology of species from microbes to man.
Nothing known to intelligent serious scientists has since been linked to mutations and evolution across billions to millions of years. Everything known to theorists has been dismissed in the context of facts that link energy-dependent furin cleavage from fixation of amino acid substitutions to naturally attenuated viral latency and the end of SARS-CoV-2 and all cancers now that Lawrence A. Tabak is the new director of the NIH.
See also: Evolving use of ancestry, ethnicity, and race in genetics research—A survey spanning seven decades 12/2/21 Before he disappeared and was found dead, CDC’s Timothy J. Cunningham linked microRNA-mediated sex differences and ethnicity to predictable differences in naturally attenuated viral endemicity and cures for all virus-driven pathology.
Differences in food and pheromone-regulated genetic processes of reproduction in species from cyanobacteria to humans are the key to understanding sex differences in cell types linked to ethnicity via the physiology of reproduction and fixation of amino acid substitution in organized genomes.
Before she was murdered, Suzanne Eaton had also published on this. See: Hedgehog Signaling Strength Is Orchestrated by the mir-310 Cluster of MicroRNAs in Response to Diet
For a historical perspective on what may be getting intelligent serious scientists killed, see: Museum für Naturkunde Explores Maria Sibylla Merian’s Legacy and Editions of Her Metamorphosis, which cites “The Wondrous Transformation of Caterpillars and their Remarkable Diet of Flowers” (1679).
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11 MIN READ
0
Bacteria see the light and they adapt
7 MIN READ
0
Organic Compounds and the Miracle of Smell and Taste
7 MIN READ
0
Stress-induced energy-dependent DNA repair
4 MIN READ
0
Ecological genomics: teleophobes respond (too late)
10 MIN READ
0
Neo-Darwinian sink testing
2 MIN READ
0
Did Brain Atrophy Evolve?
2 MIN READ
0
RNA-mediated theory killers (6) (7) (8) (9) (10)
5 MIN READ
0
Manufacturing fossil “evidence”
4 MIN READ
0
RNA-mediated theory killers
6 MIN READ
0
A two-faced protein enables RNA-mediated DNA repair (5)
4 MIN READ
0
Rivals cast doubt on facts about HGT
2 MIN READ
0
The Sherlock lab: Beneficial mutations
5 MIN READ
0
Organization of biological sequences
2 MIN READ
0
Stress-perturbed mitochondrial dysfunction
4 MIN READ
0
Cyclic cosmology and the stability of organized genomes
4 MIN READ
0
Ecological speciation. Get it, theorists?
< 1 MIN READ
0
Mystery machine vs model (2)
2 MIN READ
0
Pathology: Eating and breathing viruses
2 MIN READ
0
Nucleic acids: Stability of DNA/RNA
2 MIN READ
0
Multi-omic analysis features (SNPs, miRNA)
3 MIN READ
0
A “new” code enables ecological adaptation
4 MIN READ
0
Thermotolerance and Longevity
57 MIN READ
0
RNA-mediated permanent symbioses
11 MIN READ
0
Ecological speciation vs revised evolutionary syntheses
6 MIN READ
0
Ecology replaces the extended evolutionary synthesis
4 MIN READ
0
The stability of organized genomes (2)
5 MIN READ
0
Is the best Chinese research from China?
3 MIN READ
0
Viruses, amino acids, and somatic cell types (3)
9 MIN READ
0
Koonin: viruses killed neo-Darwinism
3 MIN READ
0
MicroRNA controlled growth and brain development
7 MIN READ
0
microRNAs and memory: Why trust a theory?
2 MIN READ
0
Protein folding and Google page rank
2 MIN READ
0
RNA-mediated development
2 MIN READ
0
Creating and maintaining the human virome
2 MIN READ
0
microRNAs, glycosylation, and genomes
4 MIN READ
0
A lighting requirement for life
11 MIN READ
3
Scientists lose. A sci-fi author gains credibility
2 MIN READ
0
Vitamin B3 and DNA repair
4 MIN READ
0
Targeting theories to fight disease
2 MIN READ
0
Five years of Ferguson
2 MIN READ
0
A special issue on nutritional epigenetics
5 MIN READ
0
Tissue type variation and expression of genes
< 1 MIN READ
0
Effect and affect of a single base-pair change
4 MIN READ
0
RNA-mediated silencing of a chromosome
3 MIN READ
0
DNA Methylation and organized genomes
7 MIN READ
0
Nutrient-dependent microRNAs control cell types
6 MIN READ
0
Anti-entropic solar energy
5 MIN READ
0
Correctly modeling ecological adaptation
4 MIN READ
0
Luis P. Villarreal tells it like it is
3 MIN READ
0
Is DNA-directed transcription RNA-mediated?
2 MIN READ
0
Virus-driven cell type differentiation
2 MIN READ
0
Rejecting what is known about viral microRNAs and nutrient-dependent microRNAs
2 MIN READ
0
Let there be anti-entropic light (1)
11 MIN READ
0
Atheism: Arrogant, useless, and divisive ignorance
7 MIN READ
0
Theoretical physics and molecular biology
5 MIN READ
0
Atoms to ecosystems is not almost a molecular ecology
3 MIN READ
0
Physicists: Desperate Acts
16 MIN READ
0
An epigenetic trap (the sequel)
10 MIN READ
0
Mute points: most are afraid to mention them
6 MIN READ
0
All of “like kind” (Part 2)
2 MIN READ
0
Models by evolutionary biologists are not models
2 MIN READ
0
Model organisms: the birds and the bees
3 MIN READ
0
Chemical ecology and RNA-mediated control of DNA loops
< 1 MIN READ
0
Dual genomes: exposing the evolution industry
5 MIN READ
0
RNA-mediated events and "The Theory of Everything"
4 MIN READ
0
Thermodynamic constraints and ecological adaptations sans evolution
6 MIN READ
0
Are mutations beneficial?
4 MIN READ
0
Biologists puzzled by evolved RNAs and decaying DNA
6 MIN READ
0
Intelligent viruses and cancers?
10 MIN READ
0
Complex behaviors of cell types in cancer
6 MIN READ
0
RNA eclipses the importance of DNA to cell type differentiation
4 MIN READ
0
Are evolutionary theorists 'nob ends'?
5 MIN READ
2
ALPHA GENOMIX
7 MIN READ
2
Nutrient-dependent gene duplication in plants (but not animals?)
4 MIN READ
0
Understanding physical forces of ecological variation and adaptation
< 1 MIN READ
0
Ecological variation and niche construction: 1, 2, 3
6 MIN READ
0
Can epigenetic inheritance occur without concurrent changes in morphology AND behavior?
3 MIN READ
0
Quantum physics meets Evolutionary Psychology News
2 MIN READ
0
RNA-mediated species diversification from microbes to primates
3 MIN READ
0
Some neuroscientists think a mutation led to human language development
< 1 MIN READ
0
Biophysically constrained beginnings of RNA and DNA
4 MIN READ
0
microRNAs and species relationships
3 MIN READ
0
Genes and Race: Human History?
2 MIN READ
0
MiRNAs methylation and ecological adaptation sans mutations
2 MIN READ
0
Don't tell the Creationists
2 MIN READ
0
Understanding the role of mutations and evolution
4 MIN READ
0
