microRNA-mediated cures (10)

By: James V. Kohl | Published on: December 25, 2021

Merry Christmas 2021!

Summary: microRNA-mediated cures for all virus-driven pathology have been linked from the 2002 Breakthrough of the Year: Small RNAs (12/19/02) to the 2021 Breakthrough of the year: Protein structures for all (12/16/21) via light-activated carbon fixation and biophysically constrained naturally-attenuated viral endemicity/latency in species from cyanobacteria to humans.
As presciently predicted in Biblical Genesis, the physiology of pheromone-regulated genetic processes is required. That fact has been exemplified in at least 3 different patents, all of which attest to the pseudoscientific nonsense touted by biologically uninformed theorists and public health fascists via recent publications on miRNAs-viral mRNAs interaction and furin cleavage.
See: microRNA-mediated cures (6)

Pfizer may not have included any information on how synthetic mRNA alters the microRNA/mRNA balance that biophysically constrains viral latency across kingdoms…”

See for comparison: Identification of homologous human miRNAs as antivirals towards COVID-19 genome 10/10/21

Host miRNAs-viral mRNAs interaction can effectively inhibit viral transmission and replication.

More than 132,000 indexed published works that mention “microRNA” link God’s Creation of anti-entropic virucidal light from energy-dependent miRNAs-viral mRNAs interaction to biophysically constrained naturally attenuated viral latency and healthy longevity across kingdoms.
These energy-dependent interactions biophysically constrain viral latency across kingdoms. That fact forced theorists acknowledge the role of the electron transfer chain and change the definition of energy.
See: Charge conservation, entropy current and gravitation 11/2/21
Reported as: Einstein finally warms up to quantum mechanics? Research team redefines energy to explain black holes 12/14/21

Surprised that other researchers have not already applied this new definition of the energy-momentum tensor… Shinya Aoki, adds that he is “also intrigued that in general curved spacetime, a conserved quantity can be defined even without symmetry.”

Intelligent serious scientists are surprised to see how far theoretical physicists will go to avoid starting with facts about God’s Creation of energy-as-information. Now that energy-dependent miRNAs-viral mRNAs interaction have been linked to naturally attenuated viral endemicity, we can revisit the fact that all theorists exemplify human idiocy in the context of Feynman’s claims about food energy. See:

If you link God’s Creation of sunlight and humidity to plant growth and food energy, you are much less likely to exemplify human idiocy. See for instance:

Moving forward, it’s been 25 years since we included a section on food energy-dependent pheromone-regulated genetic processes of reproduction that presciently linked our section on molecular epigenetics in From Fertilization to Adult Sexual Behavior to miRNAs-viral mRNAs interaction. In 1996 miRNAs were called pre-mRNAs

For the latest information about where the energy for the miRNAs-viral mRNAs interaction came from, see:

HY5 regulates light-dependent expression and accumulation of miR858a-encoded peptide, miPEP858a (12/14/21)

Peptide assay in light and dark clearly showed the essential requirement of light.

You can use facts about the light-dependent creation of the miR858a-encoded peptide to link Peptide synthesis at the origin of life (11/13/20) to the fact that MiR-290 family maintains developmental potential by targeting p21 in mouse pre-implantation embryos (12/14/21) via claims in Pre-miRNA-149 G-quadruplex as a molecular agent to capture nucleolin (12/15/21).

Alternatively, you could accept the fact that all intelligent serious scientists start with energy, not stupid theories about mutations and evolution across billions to millions of years.
The experimental evidence of light-activated energy-dependent changes in cell types completes the paradigm shift that started several decades before we included our section on molecular epigenetics in From Fertilization to Adult Sexual Behavior (1996). For instance, you could link our claims about DNA methylation to claims from DNA methylation mediates the association between breastfeeding and early-life growth trajectories 12/22/21.

…this work could help identify miRNAs responsible for breastfeeding-induced epigenetic variations, including those with positive impact and those detrimental to human health. As a whole, the evidence on milk miRNA bioactivity in health and disease remains very limited and warrants further investigations, both observational and experimental. If such function were to be validated, it could offer a tremendous paradigm shift, from a nutritional perspective, which would represent great opportunities for disease management [43, 44].

However, in a bizarre twist of fate made possible only by stupid theorists, the paradigm shift was ignored and the fact that the G-quadruplex formation was induced by K(+) ions and stabilized by ligands was inexplicably linked to self-cleaving activities despite the fact that nucleolin contains intrinsic DNA and RNA helicase, nucleic-acid-dependent and ATPase.
Theorists simply skipped past the requirement for God’s Creation of energy and experimental evidence of energy-dependent microRNA-mediated changes in cell types. They reported the cell type changes in the context of self-cleaving activities by redefining energy outside the context of energy-as-information.

Intelligent people will obviously conclude that use of the term self-cleaving activities is an attempt to dismiss the facts about energy-dependent furin cleavage.
Furin cleavage is the focus of debate about whether the SARS-CoV-2 virus was genetically engineered in the Wuhan lab, or if the novel variant emerged and evolved outside the the context of the creation of energy, which reportedly emerged from the cosmic void billions of years ago before everything on Earth began to evolve. The nonsense about self-cleaving activities is an extension of the nonsense touted by neo-Darwinian theorists.
See for comparison to the nonsense about self-cleaving activities: Roles of the polybasic furin cleavage site of spike protein in SARS-CoV-2 replication, pathogenesis, and host immune responses and vaccination 12/22/21

This review will help to provide novel insights into the effects of polybasic furin cleavage site on the current COVID-19 pandemic.

The claim can be reduced to the fact that every aspect of naturally-attenuated viral latency across kingdoms was linked from energy-dependent changes in base pairs to the functional structure of supercoiled DNA in: Structural diversity of supercoiled DNA 10/12/15
For comic relief from the pseudoscientific nonsense touted by theorists, see:

For more pseudoscientific nonsense, see: This Terrible Book Shows Why the Covid-19 Lab Leak Theory Won’t Die 12/10/21
Not only will it not die, the lab leak theory will continue to be supported by everything known to intelligent serious scientists about how to alter the microRNA-mediated energy-dependent stability of all cell types in all individuals of all species via what is known about how to alter the furin cleavage site in the context of the electron transport chain.
See: Fumarate is a terminal electron acceptor in the mammalian electron transport chain 12/2/21

…we delineate a circuit of electron flow in the mammalian ETC that maintains mitochondrial functions under oxygen limitation.

Reported as: How some tissues can “breathe” without oxygen 12/2/21

“We think there’s a lot of exciting work downstream of this to figure out how exactly this process is regulated differently in different tissues,” Spinelli said.

In 2012, I learned that all energy-dependent downstream processes of cell type differentiation in all tissues are microRNA-mediated. Theorists can no longer link the emergence of energy to the evolution of the variations in viruses unless they dismiss all the facts about the prevention of virus-driven pathology reported in MicroRNAs organize intrinsic variation into stem cell states  3/5/20
For example, on 4/25/20 Footprints of a Singular 22-Nucleotide RNA Ring at the Origin of Life confirmed the fact that one energy-dependent change in one single nucleotide polymorphism (SNP) of one microRNA could be linked to differences in all genotypes in the context of the STEM toy: “Genotype” and  Visualizing a protonated RNA state that modulates microRNA-21 maturation  10/26/20
Since then, NIH director Francis S. Collins has resigned. Our new NIH director, Lawrence A. Tabak, co-authored this refutation of all neo-Darwinian pseudoscientific nonsense: Furin cleavage of the SARS-CoV-2 spike is modulated by O-glycosylation. It was published on 11/23/21.

The novel SARS-CoV-2 coronavirus that is responsible for the global pandemic contains a unique insertion of four amino acids within the spike protein (S).

The claim about the unique insertion of four amino acids within the spike protein can be compared to stupid neo-Darwinian theories via this 2005 claim from a group of stupid theorists: Amino acid composition of proteins varies substantially between taxa and, thus, can evolve.
The ignorance of the claim that amino acids evolve was revealed by the fact that the claim was made after the 2002 Breakthrough of the Year: Small RNAs and the attempt to obfuscate top-down causation in Breakthrough of the year Protein structures for all. 12/16/21
Clearly, amino acids do not evolve and neither do proteins.
Instead, microRNA-mediated cures link Darwin’s “conditions of life” to biophysically constrained ecological adaptations.
If you are a stupid theorist who missed the paradigm shift, you will need to invent more stupid theories to protect yourself from the ridicule of intelligent serious scientists until finally the masses of intelligent people link God’s Creation of energy as information from light-activated carbon fixation to naturally attenuated viral latency and healthy longevity via these patents, which have been linked to the cure for all virus-driven diseases.

Pheromones and the luteinizing hormone for inducing proliferation of neural stem cells and neurogenesis

RNA-Guided Human Genome Engineering

The ability of different peptides to inhibit autophosphorylation of EGFR is presented by the decrease of the fluorescent signal (Y axis). 12/25/18

See also: The Science Behind Genotype: A Medelian Genetics game (page 10). It links food energy-dependent pheromone-regulated genetic processes and chromosomal rearrangements in flies from UV light-activated color changes and the fragrance of flowers to the physical characteristics and behavior of labradoodles.

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