RNAi 2002 to AI 2021 (4)

By: James V. Kohl | Published on: December 31, 2021

Happy New Year. Got SARS-Cov-2 or one of its synthetic mRNA vaccine-induced variants yet?
SARS-CoV-2 expresses a microRNA-like small RNA able to selectively repress host genes 12/28/21

…we unexpectedly discovered a viral miRNA-like small RNA, named CoV2-miR-O7a (for SARS-CoV-2 miRNA-like ORF7a-derived small RNA). Its abundance ranges from low to moderate as compared to host miRNAs and it associates with Argonaute proteins-core components of the RNA interference pathway.

For a historical perspective on the role of microRNA-like small RNAs in viruses, which they claim to have unexpectedly discovered, see for comparison to what is known about autophagy:
Autophagy is the antiphage defense strategy (2) 1/17/18
Claims about energy-dependent autophagy were linked to Viral MicroRNAs, Host MicroRNAs Regulating Viruses, and Bacterial MicroRNA-Like RNAs (2017), which was placed into the context of The emergence of light as energy from a life-giving star  6/20/17
Theorists claims about the automagical “emergence of light” were linked to:

The interactions of these small noncoding RNAs in such primitive species have wide-reaching effects, from increasing viral and bacterial proliferation, better responses to stress, increased virulence, to manipulation of host immune responses…

For instance: H5N1 influenza virus-specific miRNA-like small RNA increases cytokine production and mouse mortality via targeting poly(rC)-binding protein 2 1/12/18

We conclude that miR-HA-3p is the first identified influenza virus-encoded microRNA-like functional RNA fragment and a novel virulence factor contributing to H5N1-induced ‘cytokine storm’ and mortality.

Because stupid theorists refuse to look at, and refuse to comment on facts about microRNA-like RNAs, they tout their faith in evolution in the context of paleontology as if it was a molecular science.
See: Faith in evolution: Paleontology as a molecular science 10/16/17

Currently, only a limited number of miRNA and miRNA-like RNAs have been found in bacteria and viruses, a number that is sure to increase rapidly in the future.

Paleontologists and other stupid theorists also claim that God’s role in salvation is shrinking. See:
God’s shrinking role in salvation (2) 6/14/17

Disease is much more complicated when it cannot be linked from top-down causation via physics, chemistry, and molecular biology. See for comparison; ‘Liquid Light’ Can Bend Around Objects in a Frictionless Flow 6/10/17

Theorists who have not yet linked God’s Creation of sunlight and humidity to pH-dependent soil types, plant growth and all biodiversity via the physiology of reproduction appear to be biologically uninformed science idiots. See for comparison: Food energy-dependent cell type differentiation (2) 6/6/17
See also: Dysregulated expression and functions of microRNA-330 in cancers: A potential therapeutic target 12/27/21
Congratulations to USC’s Layla Shojaie and researchers from Iran for reminding us that every angstrom is dynamic (from the 5 prime to the 3) in the context of the cure or effective treatment for all microRNA-mediated pathology via RNA interference.
See also: miRNA-like RNAs and/or microRNA-like RNAs

Deliberately delayed obfuscation of facts about microRNA-mediated prevention of diseases is rare because energy-dependent changes in SNPs in microRNAs have been linked from light-activated carbon fixation to naturally attenuated viral endemicity across kingdoms via RNA interference since the ATP-dependent creation of RNA was experimentally established in 1964.

See: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation”

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

The new NIH director, Larry Tabak has since linked O-glycosylation from oxidative phosphorylation to amino acid substitutions and Furin cleavage of the SARS-CoV-2 spike is modulated by O-glycosylation 11/23/21
See also: Epigenetic Regulation of Epidermal Differentiation 1/1/21, which was indexed on 12/30/21.

…amino acid residues, are subject to many covalent modifications, most of which (e.g., acetylation, methylation, phosphorylation, or ubiquitination) are reversible.

See for comparison: The Postmodernism Generator web page (generates a random postmodernist article each time loaded).
Obfuscate the facts about microRNA-like RNA’s for as long as you can, but remember that you are causing unnecessary suffering and premature deaths, possibly including yours — and probably in someone you love.

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