microRNA-mediated biodiversity (1)
I started this series to show biologically uninformed evolutionary theorist that all intelligent serious scientists know how stupid the theorists have always been
A clinical and in-silico study of MicroRNA-21 and growth differentiation factor-15 expression in pre-diabetes, type 2 diabetes and diabetic nephropathy 2/1/22
RESULTS: MicroRNA-21 was found to directly target GDF15 downregulating transcription factors KLF4, TP53, and CEBPB. A significant difference in the levels of serum GDF15 was observed in Pre-diabetes (708.56 ±76.37), T2DM (1528.87 ±140.75) and DN patients (10-fold higher; 5507.90 ±503.88) when compared to healthy controls (567.36 ±69.99). The FCE of circulating hsa-miR-21 was 6.19 (Pre-diabetes), 8.22 (T2DM), 9.19 (DN), folds higher in cases as compared to controls, reflecting an increasing trend and several folds higher levels of hsa-miR-21 in patients.
You are what you eat. See also:
The end of all stupid theories was published on 1/14/22 as De novo mutation rates at the single-mutation resolution in a human HBB gene-region associated with adaptation and genetic disease
Tell me what you don’t believe about the facts. Remember, however, that light-activated carbon fixation has been linked from microRNA-mediated protein folding chemistry to healthy longevity across all kingdoms on Earth via naturally attenuated viral endemicity, the pH-dependent Creation of all soil types, RNA interference (RNAi).
Light-activated microRNA biogenesis links God’s Creation of differences in soil types from the energy-dependent physiology of pheromone-regulated genetic processes of reproduction in cyanobacteria to biophysically constrained viral latency in all cell types of all living genera via protection from the virus-driven degradation of messenger RNA during the past 6000 years.
Watch theorists appeal to their examples of human idiocy in attempts to prevent you from learning more about the facts.
Attachment is energy-dependent and microRNA-mediated
Vital Conversations Among Cells in the Lungs 4/16/17
I got lung cancer because this biologically uninformed science idiot failed to learn about light-activated carbon fixation and microRNA-mediated protection from viruses at the origin of life.
See: A substitution in the glutathione reductase lowers electron leakage and inflammation in modern humans 1/5/22
Almost all present-day humans carry an amino acid substitution (S232G) in this enzyme relative to apes and Neanderthals.
The facts about energy-dependent biophysically constrained microRNA-mediated cause and effect can be viewed in the context of energy-dependent fixation of amino acid substitutions. See: Focus on Structure to Verify Protein Function
However, the facts have been deliberately obfuscated by the failure to start with God’s energy-dependent Creation of microRNAs-mediated protein folding chemistry and RNA interference (#RNAi). In fact, the term microRNA is not mentioned in the details published as Focus on Structure to Verify Protein Function.
See for comparison: Structural diversity of supercoiled DNA 10/12/15
See for comparison my blog posts that mention: glycine, which start with