My first publication on the molecular epigenetics of RNA-mediated protein folding chemistry was our Hormones and Behavior review article: From Fertilization to Adult Sexual Behavior (1996)
We assumed that most other intelligent serious scientists would realize everything we claimed was based on pH-dependent protein folding chemistry at a time when microRNAs were called pre-mRNAs.
Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans (Adler and Hajduk, 1994; de Bono, Zarkower, and Hodgkin, 1995; Ge, Zuo, and Manley, 1991; Green, 1991; Parkhurst and Meneely, 1994; Wilkins, 1995; Wolfner, 1988). That similar proteins perform functions in humans suggests the possibility that some human sex differences may arise from alternative splicings of otherwise identical genes.
…nucleotides within the three base pair mismatches displayed unique structural properties, including varying dynamics and sensitivity to solution pH.
Ask a theorist about the role of pH in Non-cell autonomous disruption of nuclear architecture as a potential cause of COVID-19 induced anosmia 2/2/22
Our data provide a potential mechanism by which SARS-CoV-2 infection alters the cellular morphology and the transcriptome of cells it cannot infect, offering insight to its systemic effects in olfaction and beyond.
Other works by Benjamin R. tenOever and Stavros Lomvardas, a member of tenOever’s group, link my model of light-activated carbon fixation in cyanobacteria and energy-dependent microRNA-mediated protein folding chemistry to the end of all virus-driven pathology and changes in the potential of hydrogen (pH), via external factors such as temperature and stress that influence microRNA-mediated protein folding chemistry via changes in hydrogen bond.
See for comparison to tenOeer’s claims about systemic effects in olfaction and beyond: Olfaction Warps Visual Time Perception 3/17/17
For links from tenOeer’s claims to other facts that link olfaction to visual perception via microRNA-mediated protein folding chemistry, see: MicroRNA-based strategy to mitigate the risk of gain-of-function influenza studies 8/11/13
Recent gain-of-function studies in influenza A virus H5N1 strains revealed that as few as three-amino-acid changes in the hemagglutinin protein confer the capacity for viral transmission between ferrets1,2.
This was reported in 2005: Characterization of the reconstructed 1918 Spanish influenza pandemic virus 10/7/05.
This was reported in 2007: A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmission 2/2/07
Presumably, tenOever and Lamvardas are not too stupid to link stress-linked reactivation of endogenous retroviruses, including human endogenous retroviruses (HERVs) from one more virus-driven change in an amino acid substitution to the development of SARS-CoV-2-driven COVID-19 via the imbalanced response and one amino acid substitution in the virus that drives the reactivated pathological response. Indeed, that’s what tenOever’s group reported on 5/15/20.
We propose that reduced innate antiviral defenses coupled with exuberant inflammatory cytokine production are the defining and driving features of COVID-19.
Here, we demonstrate the balance that negative-sense RNA viruses must achieve both to replicate efficiently and to avoid induction of the host defenses.
Virus-driven constraint-breaking mutations have been linked to all pathology across kingdoms. They are antithetical examples of how microRNA-mediated protein folding chemistry has been linked to the prevention of all virus-driven pathology during 6000 years of ecological adaptations across kingdoms.
See: The Darwin Code: Intelligent Design without God and
If you are a biologically uninformed neuroscientist who refuses to discuss facts about energy-dependent microRNA-mediated protein folding chemistry & sympatric speciation in the context of fixation of amino acid substitutions and how olfaction warps visual perception, find others like you on the Neuroscience FB group. Support each others’ research by failing to mention anything about the microRNA-mediated protein folding chemistry that protects all organized genomes from the virus-driven degradation of messenger RNA.