microRNA-mediated biodiversity (3)

By: James V. Kohl | Published on: February 6, 2022

See first: The tipping point (revisited): 135K

Conclusion: Eating food, for example, is the required link to ecological adaptations.

See also: Museum für Naturkunde Explores Maria Sibylla Merian’s Legacy and Editions of Her Metamorphosis

The Wondrous Transformation of Caterpillars and their Remarkable Diet of Flowers

Moving forward:
Fixation of amino acid substitutions in organized primate genomes is food energy-dependent. Pheromone-regulated genetic processes of reproduction link the fixation of the amino acid substitutions to sympatric speciation across kingdoms. This is how the virus-driven degradation of messenger RNA in soil bacteria is linked to plant growth and the physiology of pH-dependent reproduction in mammals. It is how microRNA-mediated protein folding chemistry is linked to prevention or to the effective treatment of all virus-driven pathology.
See for example: Whole-Genome Analysis to Determine the Rate and Patterns of Intra-Subtype Reassortment Among Influenza Type-A Viruses in Africa 1/29/22

…this study provides evidence and heightens our knowledge on IAVs evolution which is integral in directing vaccine strain selection and the update of master donor viruses used in recombinant vaccine development.

Food energy-dependent pheromone-regulated genetic processes of reproduction link microRNA-mediated protein folding chemistry to prevention of virus-driven pathology during the past 6000 years of ecological adaptations.
For more than 1800 examples, see: HbVar: A Database of Human Hemoglobin Variants and Thalassemias

“…humans and chimpanzees have identical beta chain hemoglobin… The beta chain has 146 amino acids, the alpha chain has 141 amino acids… A person with sickle cell anemia would have 1 difference…compared to a normal human or chimpanzee.

See for comparison: Evolution of host-microbe cell adherence by receptor domain shuffling 1/25/22. It was reported on 2/4/22 as Primate proteins evolve to guard against pathogens, study finds

The fact that hemoglobin variants are not typically linked to fixation of amino acid substitutions and protection from viruses fits perfectly with the most ignorant claim ever made by any theorists: See:  A universal trend of amino acid gain and loss in protein evolution 2/10/05

Amino acid composition of proteins varies substantially between taxa and, thus, can evolve.

See for comparison: Genotype for ages 14+
Tomi Aalto and many others like him have taken the facts I have detailed about microRNA-mediated protein folding chemistry and fixation of amino acid substitutions, and presented them as if the facts were their discovery. See for instance:

Epigenetic mechanisms and factors behind protein diversity 9/7/21

Instructions for protein production are not stored in DNA

My first publication on the molecular epigenetics of RNA-mediated protein folding chemistry was our Hormones and Behavior review article: From Fertilization to Adult Sexual Behavior (1996)
We assumed that most other intelligent serious scientists would realize everything we claimed was based on pH-dependent protein folding chemistry at a time when microRNAs were called pre-mRNAs.

Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans (Adler and Hajduk, 1994; de Bono, Zarkower, and Hodgkin, 1995; Ge, Zuo, and Manley, 1991; Green, 1991; Parkhurst and Meneely, 1994; Wilkins, 1995; Wolfner, 1988). That similar proteins perform functions in humans suggests the possibility that some human sex differences may arise from alternative splicings of otherwise identical genes.

See for comparison: pH dependence of C•A, G•A and A•A mismatches in the stem of precursor microRNA-31

…nucleotides within the three base pair mismatches displayed unique structural properties, including varying dynamics and sensitivity to solution pH.

Ask a theorist about the role of pH in Non-cell autonomous disruption of nuclear architecture as a potential cause of COVID-19 induced anosmia 2/2/22

Our data provide a potential mechanism by which SARS-CoV-2 infection alters the cellular morphology and the transcriptome of cells it cannot infect, offering insight to its systemic effects in olfaction and beyond.

Other works by Benjamin R. tenOever and Stavros Lomvardas, a member of tenOever’s group, link my model of light-activated carbon fixation in cyanobacteria and energy-dependent microRNA-mediated protein folding chemistry to the end of all virus-driven pathology and changes in the potential of hydrogen (pH), via external factors such as temperature and stress that influence microRNA-mediated protein folding chemistry via changes in hydrogen bond.

See for comparison to tenOeer’s claims about systemic effects in olfaction and beyond: Olfaction Warps Visual Time Perception 3/17/17
For links from tenOeer’s claims to other facts that link olfaction to visual perception via microRNA-mediated protein folding chemistry, see: MicroRNA-based strategy to mitigate the risk of gain-of-function influenza studies  8/11/13

Recent gain-of-function studies in influenza A virus H5N1 strains revealed that as few as three-amino-acid changes in the hemagglutinin protein confer the capacity for viral transmission between ferrets,.

This was reported in 2005: Characterization of the reconstructed 1918 Spanish influenza pandemic virus 10/7/05.
This was reported in 2007:  A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmission 2/2/07
Presumably, tenOever and Lamvardas are not too stupid to link stress-linked reactivation of endogenous retroviruses, including human endogenous retroviruses (HERVs) from one more virus-driven change in an amino acid substitution to the development of SARS-CoV-2-driven COVID-19 via the imbalanced response and one amino acid substitution in the virus that drives the reactivated pathological response. Indeed, that’s what tenOever’s group reported on 5/15/20.

See:  Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

We propose that reduced innate antiviral defenses coupled with exuberant inflammatory cytokine production are the defining and driving features of COVID-19.

See also:  Reduced Nucleoprotein availability impairs negative-sense RNA virus replication and promotes host recognition 4/12/21

Here, we demonstrate the balance that negative-sense RNA viruses must achieve both to replicate efficiently and to avoid induction of the host defenses.

Virus-driven constraint-breaking mutations have been linked to all pathology across kingdoms. They are antithetical examples of how microRNA-mediated protein folding chemistry has been linked to the prevention of all virus-driven pathology during 6000 years of ecological adaptations across kingdoms.
See: The Darwin Code: Intelligent Design without God and

The Darwin Code: Intelligent Design without God” (2)

The Darwin Code: Intelligent Design without God” (3)

The Darwin Code: Intelligent Design without God” (4)

If you are a biologically uninformed neuroscientist who refuses to discuss facts about energy-dependent microRNA-mediated protein folding chemistry & sympatric speciation in the context of fixation of amino acid substitutions and how olfaction warps visual perception, find others like you on the Neuroscience FB group. Support each others’ research by failing to mention anything about the microRNA-mediated protein folding chemistry that protects all organized genomes from the virus-driven degradation of messenger RNA.

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