microRNA-mediated biodiversity (8)

Former President Trump’s 4/23/20 claims about sunlight & humidity have been linked from light-activated carbon fixation in cyanobacteria to microRNA-mediated protein folding chemistry and from “Footprints of a Singular 22-Nucleotide RNA Ring at the Origin of Life (4/25/20) to microRNA-mediated prevention or effective treatment of cancer and other virus-driven pathology via Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants

Three different extant databases have established the facts:  Mammarena viruses database, HbVar and ClinVar. As noted in microRNA-mediated biodiversity (6)

…the Mammarena viruses database links…differences in soil bacteria to plant growth and microRNA-mediated protein folding chemistry via fixation of amino acid substitutions in hemoglobin variants that protect non-human primates and humans from the virus-driven degradation of messenger RNA.

See the updates to HbVar: A Database of Human Hemoglobin Variants and Thalassemias

The facts can now be linked from energy-dependent single nucleotide variants to all biodiversity via the ClinVar database .

ClinVar is a freely accessible, public archive of reports of the relationships among human variations and phenotypes, with supporting evidence. ClinVar thus facilitates access to and communication about the relationships asserted between human variation and observed health status, and the history of that interpretation. ClinVar processes submissions reporting variants found in patient samples, assertions made regarding their clinical significance, information about the submitter, and other supporting data. The alleles described in submissions are mapped to reference sequences, and reported according to the HGVS standard. ClinVar then presents the data for interactive users as well as those wishing to use ClinVar in daily workflows and other local applications. ClinVar works in collaboration with interested organizations to meet the needs of the medical genetics community as efficiently and effectively as possible.

Forensic medicine specialists have moved so far ahead of stupid theorists that “mutation-driven evolution” via natural selection for beneficial mutations is not something they are willing to discuss. How did that happen?

The alphavirus 3′-nontranslated region: size heterogeneity and arrangement of repeated sequence elements 1/5/98 was reported as:

The 19-nt conserved sequence element directly adjacent to the poly(A) tract was found in all viruses, supporting the hypothesis that this region is a cis-acting sequence element during viral replication and essential for virus growth in vitro.

See for comparison to newer information on conserved sequences:  Mutational analysis of Aedes aegypti Dicer 2 provides insights into the biogenesis of antiviral exogenous small interfering RNAs 1/7/22

Combined with the importance of the Dcr2 helicase domain, this suggests that the majority of 21 nt vsiRNAs originate by processive cleavage. This study sheds new light on Ae. aegypti Dcr2 functions and properties in this important arbovirus vector species.

Who failed to link the facts about conserved nucleotide (nt) sequences to Alphavirus RNA genome repair and evolution: molecular characterization of infectious sindbis virus isolates lacking a known conserved motif at the 3′ end of the genome 12/22/20

The 3′ nontranslated region of the genomes of Sindbis virus (SIN) and other alphaviruses carries several repeat sequence elements (RSEs) as well as a 19-nucleotide (nt) conserved sequence element (3’CSE). The 3’CSE and the adjoining poly(A) tail of the SIN genome are thought to act as viral promoters for negative-sense RNA synthesis and genome replication.

Why did it take ~24 years to link light-activated carbon fixation in cyanobacteria to microRNA-mediated protein folding chemistry and viral endemicity via conserved nucleotide sequences and the biogenesis of antiviral exogenous small interfering RNAs?