Photonics in Forensics (5)
Crosstalk between codon optimality and cis-regulatory elements dictates mRNA stability 1/5/21
However, the strength of this mechanism during embryogenesis, as well as its relationship with other known regulatory elements, such as microRNA, remains unclear.
God’s Creation of sunlight and humidity biophysically constrains the pH-dependent crosstalk via oxidative phosphorylation and stem cell creation. That fact about microRNAs is perfectly clear.
See: MicroRNAs organize intrinsic variation into stem cell states 3/5/20
…the results presented here suggest that naturally arising cell-to-cell variation, sometimes described as stochastic fluctuation, is in fact coherently organized biology.
For an example of how far stupid theorists will go to avoid stating clearly that natural selection for energy-dependent codon optimality links quantum coherence to coherently organized biology via the sense of smell in bacteria, what organisms eat, the physiology of reproduction, and light-activated microRNA biogenesis in plants, see:
Answers here deepen any current understanding for the process of abiogenesis.
(c) A current view adds the standard amino acid alphabet to the list of central dogma components, which appear optimized relative to plausible alternatives, along with strengthened evidence for RNA and the genetic code as outcomes of natural selection. Emerging insights about adaptive, evolutionary behaviour from collections of molecules far removed from nucleic acid sequences suggest that biological evolution by natural selection is a narrowed (refined) subset of broader processes by which matter (chemicals) change over time. Philosophically, this view aligns with calls to re-think life’s emergence as a continuous process rather than any specific point in time or biochemistry. More practically, these same findings dissolve any clear distinction between the evolution of genetic versus metabolic aspects of life’s biochemistry.
Theorists love the idea of abiogenesis. Most of the other claims from this article regurgitate the nonsense from Jeremy England’s A New Physics Theory of Life (1/23/14)
If England’s approach stands up to more testing, it could further liberate biologists from seeking a Darwinian explanation for every adaptation and allow them to think more generally in terms of dissipation-driven organization.
No stupid theories of dissipation-driven organization (i.e., entropy) have ever stood up to testing. Ecological adaptations are energy-dependent. They are not driven by dissipation of energy.
Thank God, intelligent biologists do not think in terms of dissipation-driven organization of cell types across species. Natural selection for energy-dependent codon optimality links light-activated carbon fixation in cyanobacteria to biophysically constrained microRNA-mediated protein folding chemistry and healthy longevity across all kingdoms on Earth via more that 136,380 indexed publications that mention microRNAs.
On 11/5/21, our NIH director helped to expose the facts about energy-dependent furin cleavage. See: Furin cleavage of the SARS-CoV-2 spike is modulated by O-glycosylation. Simply put, he linked it to former President Trump’s claims on 4/23/20 that sunlight and humidity weaken coronaviruses, which forced the resignation of Francis S. Collins and Eric Lander. Both of them failed to link Lawrence A. Tabak’s claims to Footprints of a Singular 22-Nucleotide RNA Ring at the Origin of Life 4/25/20
Trump’s scientific advisor was KB Whaley. Biden’s was Eric Lander, until intelligent people noticed that Lander had already linked naturally occurring energy-dependent RNA interference (RNAi) to Trump’s 4/23/20 claims in 2012 via a patent held by George M. Church et al., from Harvard. That exposed the overwhelming corruption at every level of US government, and in most other governments. See:
See: MicroRNA 3′-compensatory pairing occurs through two binding modes, with affinity shaped by nucleotide identity and position 2/22/22
David P Bartel’s lab has consistently shown that stupid neo-Darwinian theorists will never be anything more than stupid neo-Darwinian theorists who believe in stupid things like abiogenesis and dissipation-driven organization.
For a historical perspective linked from effective treatment of COVID19 to effective treatment of cancer and to the war in the Ukraine, see also:
MicroRNA-based regulation of epithelial–hybrid–mesenchymal fate determination 11/5/13
Mesenchymal Stem Cell-Derived Extracellular Vesicles as Therapeutics and as a Drug Delivery Platform 5/2/19
Influence of mesenchymal stem cell-derived extracellular vesicles in vitro and their role in ageing 1/3/20
Mesenchymal Stem Cell-Derived Extracellular Vesicles in Tissue Regeneration 3/24/20
Mesenchymal Stem Cell-Derived Extracellular Vesicles Carrying miRNA as a Potential Multi Target Therapy to COVID-19: an In Silico Analysis 1/28/21
[MicroRNAs as the Potential Regulators of SARS-CoV-2 Infection and Modifiers of the COVID-19 Clinical Features]1/28/22
When researchers from Russia reported they knew how to regulate the modifiers of SARS-CoV-2 infection, it was a green light for Putin to invade a NATO-protected country. He realized that if researchers in the USA couldn’t stop COVID-19 via what former President Trump knew, that President Biden could do nothing to stop him from taking control of the Ukraine.
Next we will probably see China take control of Taiwan, because researchers in China reported they know how to cure or effectively treat cancer by regulating microRNA-mediated autophagy and epithelial-mesenchymal transition (EMT).
See: Regulatory effects of lncRNAs and miRNAs on the crosstalk between autophagy and EMT in cancer: a new era for cancer treatment 1/27/22
Everything that goes on in Communist and non-Communist countries has been linked from God’s Creation of sunlight and humidity to the ATP-dependent creation of RNA and the patent for naturally occurring RNA interference.
RNA-Guided Human Genome Engineering, which was reported on 3/3/16 to be A Billion Dollar Baby in Therapy in Get Well in the RNAi Way-RNAi,
RNAi has targeted exogenous genes in models of viral infection…