RNA-mediated silencing (8)

By: James V. Kohl | Published on: April 1, 2022

Now fully complete, human genome reveals new secrets 3/31/22 reports on:
A next-generation human genome sequence 3/31/22
From telomere to telomere: The transcriptional and epigenetic state of human repeat elements 4/1/22
The complete sequence of a human genome 4/1/22
Epigenetic patterns in a complete human genome 4/1/22
Complete genomic and epigenetic maps of human centromeres 4/1/22
The articles and the reporting obfuscate the fact that God’s Creation of energy-as-information links sunlight and humidity to His Creation of all biodiversity on Earth via oxygen-dependent RNA-mediated pH-dependent viral endemicity.
For a historical perspective on the amount of pseudoscientific nonsense included in the most recent attempts to keep the ignorant masses focused on stupid theories, see:
Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” (1964)

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

From Fertilization to Adult Sexual Behavior (1996)

The concept of the environment used for our discussion is very broad; it incorporates considerations of both the molar and the molecular levels.

Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems 4/18/18

This angstroms to ecosystems model of ecological adaptation links nutrient energy-dependent epigenetic effects on base pairs and amino acid substitutions to pheromone-controlled changes in the microRNA/messenger RNA balance and chromosomal rearrangements via the physiology of reproduction in species from microbes to humans. The nutrient-dependent pheromone-controlled changes are required for the thermodynamic regulation of intracellular signaling, which enables biophysically constrained nutrient-dependent protein folding; experiencedependent receptor-mediated behaviors, and organism-level thermoregulation in ever-changing ecological niches and social niches. Nutrient-dependent ecological, social, neurogenic and socio-cognitive niche construction are manifested in increasing organismal complexity. Species-specific pheromones link quorum-sensing in microbes from chemical ecology to the physiology of reproduction. The reciprocal relationships of species-typical nutrient-dependent morphological and behavioral diversity are enabled by pheromone-controlled reproduction. Ecological variations and biophysically constrained natural selection for codon optimality links nutritional epigenetics to the behaviors that enable ecological adaptations. All biodiversity is an ecologically validated proof-of-concept. Ideas from population genetics, which exclude ecological factors, are integrated with an experimental evidence-based approach that establishes what is currently known. Simply put, olfactory/pheromonal input links food odors and social odors from the epigenetic landscape to the physical landscape of supercoiled DNA in the organized genomes of species from microbes to man during their development.

See also for ages 8-14+ ION, Covalence, Subatomic, Periodic, Peptide, Virulence, Cytosis, Virus Expansion, Genotype, Ecosystem, and Cellulose: A Plant Cell Biology Game

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