MicroRNA-mediated existential threats (4)

By: James V. Kohl | Published on: April 24, 2022

See first:  MicroRNA-mediated existential threats (3)

How can it not be perfectly clear that stupid theories about the evolution of amino acid composition in proteins ignore everything known to all intelligent serious scientists about light-activated carbon fixation, pH-dependent microRNA biogenesis and every aspect of biophysically constrained viral latency that was altered by SARS-CoV-2 mRNA vaccinations?
See: RBM6 splicing factor promotes homologous recombination repair of double-strand breaks and modulates sensitivity to chemotherapeutic drugs 10/28/21
See for comparison to claims about alternative splicings see claims about non-homologous end joining.
Energy-dependent alternative splicings are consistently linked to ecological adaptations via microRNA-mediated protein folding chemistry. See for comparison: RNA-binding proteins and cancer metastasis 3/23/22

…recent advances for helping us understand the role of RBPs in tumor metastasis, and discuss dysfunctions and dysregulations of RBPs affecting metastasis-associated processes including epithelial-mesenchymal transition (EMT), migration, and invasion of cancer cells.

For the latest report on scientific progress that links energy-dependent epithelial-mesenchymal transitions to ecological adaptations, see: Mechanisms of non-coding RNA-modulated alternative splicing in cancer  4/15/22

Over 90% of human intron-containing genes undergo alternative splicing (AS) to form multiple mRNA isoforms [1–3]. AS is generated via splicing at different splice sites or selective removal of introns from a single precursor mRNA (pre-mRNA) [2]. The process is highly and tightly controlled, mainly relying on splicing sites and splicing factors (SFs) such as serine/arginine-rich (SR) proteins, heterogeneous nuclear ribonucleoproteins (hnRNPs), and tissue-specific SFs [4–6].

No experimental evidence links natural selection for beneficial mutations to evolution across billions to millions of years.
Historical perspective
https://www.tandfonline.com/doi/full/10.1080/15476286.2022.2062846 Earlier tonight I discussed our 1996 review of facts about alternative splicings of pre-mRNA with an intelligent woman who understood the role that fixation of amino acid substitutions plays in #viral_endemicity and prevention of stress-linked diseases.
The link from my military service & training as a medical laboratory scientist led to a 10-part series on the microRNA-mediated future of humanity 2 years ago, before Trump’s claim that sunlight & humidity weaken #COVID19 was confirmed in the context of #cancer prevention.
An anonymous fool replied:

None of this is of any consequence to anybody unless you can explain it in terms which they can understand.

And as you can’t your ideas will likely follow you to the grave.

Publication of “The scent of eros: mysteries of odor in human sexuality” https://t.co/SHapW5AHOQ (for a general audience) and the tech-savvy “From Fertilization to Adult Sexual Behavior” in Hormones and Behavior https://www.hawaii.edu/PCSS/biblio/articles/1961to1999/1996-from-fertilization.html preceded my death by at least 2.5 decades.
See: From Fertilization to Adult Sexual Behavior

Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation…

I woke last night to the sound of thunder. Before I went back to sleep, I linked God’s Creation of sunlight and humidity at the origin of life ~6000 years ago to His energy-dependent protection from all virus-driven diseases via the growth of Angel_Trumpets and Visualizing a protonated RNA state that modulates microRNA-21 maturation (10/26/20).
I did not try to link virus-driven energy theft from mutations to evolution during billions to millions of years because no experimental evidence links mutations to anything except diseases.
Stop the unnecessary suffering and premature deaths caused by the arrogance and ignorance of theorists who used “big data” for fun at your expense. Energy is information. Data is manipulated by theorists for profit.
Be like Elon Musk.
Promote free speech, not censorship by people like Leslie Thurston, Susie Byrne, Tammy Alenduff and several of their friends who have blocked me on Facebook after repeatedly claiming that, like former President Trump, I am a bully.
Biophysically constrained viral endemicity was linked from the ATP-dependent Creation of RNA to healthy longevity via fixation of amino acid substitutions in the cell wall via my mentor. See McEwen et al. (1964)

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

See also: Brain on stress: How the social environment gets under the skin 10/8/12 and
Correction for McEwen, Brain on stress: How the social environment gets under the skin

The authors note that on page 17184, right column, first paragraph, line 4, “effect” should instead appear as “affect.”

I learned to differentiate between “effect” and “affect” from Bruce S. McEwen. In my model, stress-linked virus-driven degradation of mRNA in intracellular microbiota causes metastatic colonization  of cancerous tissues via virus-drivent failed activation of the cell death gene.
See for comparison:  Tumor-resident intracellular microbiota promotes metastatic colonization in breast cancer 4/7/22

…tumor-resident microbiota, albeit at low biomass, play an important role in promoting cancer metastasis, intervention of which might therefore be worth exploring for advancing oncology care.

Thanks to Thomas E. Ichim for menitoning this.
Link the energy-dependent creation of RNA to Thomas E. Ichim’s patents for mRNA-based therapeutic strategies. Get GenScript’s New Free in vitro transcribed (IVT) mRNA Infographic
My top follower on twitter now has 310,000 followers. The “Medvira Newsroom” may help you put Thomas E. Ichem’s 204 patents for therapeutic solutions to healthy longevity across kingdoms.
May be a Twitter screenshot of text that says 'Top Follower followed by 310K people BNO/MEDRIV NEWS BNO|Medriva Newsroom @medriva FOLLOWS YOU In collaboration with @MedrivaLife, BNO is your most trusted coronavirus media newsroom bringing you up to the minute news, research & coverage. DM for tips'
For example, on 4/18/22 Medvira.com reported on The Unfortunate Situation China Finds Itself In

China has been experiencing a wave of coronavirus outbreaks attributed to the emergence of new, different variants…

Protection from the variants is food energy-dependent and microRNA-mediated. Learn how “Therapeutic Solutions” established that fact by eliminating stupid theories about mutation-driven evolution.
Q: Are Evolution and Adaptation the Same? 4/30/18
A: No. I detailed the differences on 4/18/18 via publication of Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems
The consistent failure of theorists to explain the difference between evolution and adaptations was caused by the fact that they do not start with God’s Creation of energy. That fact led other fools to claim that former President Trump and I are bullies because we start with God’s Creation of sunlight and humidity and link it from the weakening of COVID19 to effective therapeutic solutions for all virus-driven pathology via RNA interference (RNAi).

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