Epistemic corruption (6)
Summary: The rapid pace of experimental evidence linked to Selective MicroRNA-Offset RNA Expression in Human Embryonic Stem Cells 3/30/15 can be compared to the nonsense touted by neo-Darwinian theorists published as Shining Light on the Evolution of Photosynthesis 12/1/03
Photosynthetic bacteria and eukaryotes collect light energy for photosynthesis in structures called light-harvesting antenna complexes.
Unless the light-harvesting complexes automagically created themselves, the facts about God’s Creation of sunlight link light-activated carbon fixation in cyanobacteria to pH-dependent microRNA-mediated protein folding chemistry, and to the patented cure for all virus-driven pathology, which is RNA interference (RNAi). RNAi is also known as the patented RNA-Guided Human Genome Engineering.
The title of the patent was probably used to obfuscate the facts about RNAi, which is required to protect all organized genomes from the virus-driven degradation of messenger RNA and all virus-driven pathology via the Creation of stem cells.
The author of the article on photosynthesis, Richard Swindell, blocked me on Facebook after our discussion led me to link the ATP-dependent creation of RNA from the patent for naturally occurring RNA interference to God’s Creation of stem cells via MicroRNAs organize intrinsic variation into stem cell states 3/5/20.
He ended discussion after I mentioned that Thomas Hunt Morgan’s prescient claims about chromosomal rearrangements in flies (1910) were linked to sympatric speciation across kingdoms in the 11/6/18 preprint and the 4/29/22 publication of Photoperiod-Dependent Expression of MicroRNA in Drosophila.
The accurate anticipation of the incoming season is vital for development, reproduction, and fitness, and requires a seasonal timer [2,3] that is often based on photoperiod measurement. The molecular details of this photoperiodic timer are still elusive, despite decades of intense research [2,4]. Recently, however, significant progress has been made [5,6,7,8].
Significant progress was first made when God’s Creation of sunlight and humidity were linked from microRNA-mediated protein-folding chemistry to the molecular details of differences in the hemoglobin variants of blood cells via the the photoperiodic timer, which links plant growth from what other animals eat, and what people eat, to differences in hemoglobin variants.
See: Updates of the HbVar database of human hemoglobin variants and thalassemia mutations 10/9/13
Hemoglobinopathies are the commonest single-gene genetic disorders in humans, resulting from pathogenic genome variants in the human α-like and β-like globin gene clusters (reviewed in 1). Single nucleotide substitutions or indels [INsertions/DELetionS] can lead to several hemoglobin variants owing to amino acid replacements, while molecular defects in either regulatory or coding regions of the human HBA2, HBA1, HBB or HBD genes can minimally or drastically reduce their expression, leading to α-, β- or δ-thalassemia, respectively.
For facts about prevention of hemoglobinopathes et al., see: Footprints of a Singular 22-Nucleotide RNA Ring at the Origin of Life 4/25/20 They authors linked a model of RNAi, fixation of amino acids and peptide interactions from biophysically constrained fixation of amino acid substitutions to more than 200 patents linked to stem cell creation ~6000 years ago, and to more than 141,000 indexed publications that mention microRNAs. There have been 1000 additions to the indexed publications since 5/2/22.
Given the rate of additions to the PubMed database of indexed publications that mention microRNAs, it is likely that all theorists will soon realize that they have behaved like biologically uninformed science idiots who failed to link energy-dependent change in microRNAs to the facts in: Map of Human Blood Stem Cell Development Created 4/13/22
“Now, we can place the cells in our roadmap to see where we’re succeeding, where we’re falling short and fine-tune the differentiation process according to the instructions from the embryo.”
See our 1996 Hormones and Behavior review of the energy-dependent differentiation process across kingdoms. We included a section on molecular epigenetics in From Fertilization to Adult Sexual Behavior
Energy-dependent epigenetic effects on organized genomes link ecological variation to natural selection for codon optimality and fixation of amino acid substitutions linked to ecological adaptations. That fact was reported as: Tracking niche variation over millennial timescales in sympatric killer whale lineages 10/7/13
Ecological variation is the raw material by which natural selection can drive evolutionary divergence [1–4].
The differences in amino acid composition among different tissues can lead to large differences in trophic discrimination .
See for comparison to an example of human idiocy: Morphology and Ultrastructure of the Amazon River Dolphin (Inia geoffrensis) Spermatozoa 3/3/17
The spermatozoa showed an elongated ellipsoid shaped head and a long tail with a well distinguishable midpiece.
This was reported as: Amazon river dolphin may actually be multiple species 5/11/22
…the skulls of these dolphins vary substantially between populations in different river basins in South America. If their physical differences represent evolutionary adaptations rather than just random variation within a population, there could be profound conservation implications for these animals…
Variation in skulls is a common example of how theorists link observations to cause and effect outside the context of energy-dependent cause and effect.
When statistical evidence fails to support the claims of stupid theorists, they are forced to make claims about the number of multiple species. They got stuck with the stupid theories, and failed to link the virus-driven extinction of Angel Trumpets in the wild to our species extinction via claims about the evolution of multiple species of humans in:
–from the 2013 book Shaping Humanity: How Science, Art and Imagination Help Us Understand Our Origins by John Gurche.
See for comparison my 2013 refutation of neo-Darwinian pseudoscientific nonsense: Nutrient-dependent/pheromone-controlled adaptive evolution: a model