Codon optimality vs systemic fraud (2)

By: James V. Kohl | Published on: June 9, 2022

See first: Codon optimality vs systemic fraud (1)

  1. Researchers identified over 5,500 new viruses in the ocean, including a missing link in viral evolution 4/8/22 and
  2. Ocean water samples yield treasure trove of RNA virus data 4/8/22
  3. attest to facts about the Footprints of a Singular 22-Nucleotide RNA Ring at the Origin of Life 4/25/20
  4. that link God’s ATP-dependent Creation of RNA from RNA-peptide interactions at the origin of life to the Mapping and characterization of structural variation in 17,795 human genomes 7/1/20 via
  5. the Biogenesis and Regulatory Roles of Circular RNAs 5/24/22

The biogenesis of circular RNAs and their regulatory roles link our claims in the molecular epigenetics section of From Fertilization to Adult Sexual Behavior (1996) to reports on experimentally established facts about biophysically constrained viral endemicity across kingdoms.
For a historical perspective see:
See: Centromeres cross over, a lot 6/12/08
Portuguese scientists working on chromosome segregation 7/1/09
At the crossroads of chromosomes: Study reveals structure of cell division’s key molecule 9/16/10
Kinetochores prefer the ‘silent’ DNA sections of the chromosome 7/5/11
Two unsuspected proteins may hold the key to creating artificial chromosomes 4/28/11
Making and breaking heterochromatin 9/25/12
Illuminating the dark side of the genome 7/29/14
Humans may have benefited from mobile genetic element insertions 9/10/14
Thousands of never-before-seen human genome variations uncovered 11/10/14
A thorough characterization of structural variants in human genomes 4/16/19
Thai scientists catch bats to trace virus origins 8/13/20
Bats in Switzerland harbor diverse viruses, some potentially zoonotic 6/16/21
15,000-year-old viruses discovered in Tibetan glacier ice 7/20/21
Novel coronavirus discovered in British bats 11/23/21
See for review of nutrient-dependent pheromone-regulated genetic processes of reproductiion: Rapid evolution of male reproductive genes in the descent of man 1/20/2000
Positive Darwinian selection (natural selection for food energy-dependent codon optimality) is obviously the driving force behind rapid ecological adaptations, which are exemplified in Drosophila, marine invertebrates, mouse, rat and in primates.
In primates, Dobzhansky (1973) linked natural selection for energy-dependent codon optimality to fixation of one amino acid substitution that differentiated humans and chimpanzees from gorillas.

For example, the so-called alpha chains of hemoglobin have identical sequences of amino acids in man and the chimpanzee, but they differ in a single amino acid (out of 141) in the gorilla (p. 127).

For differences in hemoglobin variants and individuals of the same species, see: HbVar: A Database of Human Hemoglobin Variants and Thalassemias

The hemoglobinopathies, or Hb variants, are attributable to amino acid substitution(s) in either globin chain. Currently, 1417 total hemoglobin variants have been characterized.

Knowing that hemoglobin variants are nutrient-dependent and constrained by the physiology of pheromone-regulated genetic processes of reproduction in species from yeasts to primates, led Pfizer to acquire Trillium Therapeutics.
See: Pfizer Completes Acquisition of Trillium Therapeutics 11/17/21 The acquisition attests to the fact that nutrient-dependent pheromone-regulated genetic processes of reproduction have been linked to this patent, which is assigned to Trillium. Pheromones and the luteinizing hormone for inducing proliferation of neural stem cells and neurogenesis
It was previously assigned to Stem Cell Therapeutics Corp., but it’s been linked to the Official Twitter handle of the RNA Therapeutics Institute, which claims to be uniting nucleic acid scientists with clinicians to devise human therapies.
Save the dates for June 22-24, 2022 for the 4th annual RNA Therapeutics Symposium.  2022 RNA Therapeutics: From Concept to Clinic
Wait to see if obfuscation of the facts prevents you from understanding what led Thomas Ichim to patent 207 therapeutic solutions for virus-driven pathology based on his knowledge of light-activated biophysically constrained stem cell Creation at the origin of life ~6000 years ago, and the Biogenesis and Regulatory Roles of Circular RNAs 5/24/22.

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