Pheromone-regulated genetic processes (1)

By: James V. Kohl | Published on: September 11, 2022

See: The physics of existence (1-10)

 

Moving forward:

Microtubule regulation: Transcending the tenet of K40 acetylation 2/7/2

…acetylation of lysine 394 in α-tubulin also mediates microtubule stabilisation in neurons.

That fact has been linked to The potential role of the mobile and non-coding genomes in adaptive response  9/1/22

Energy-dependent pheromone-regulated genetic processes of reproduction link miRNAs and human endogenous retroviruses (HERVs) from feedback loops to viral endemicity or to healthy longevity across kingdoms via fixation of amino acid substitutions in microtubules via the role that glycine plays in construction of the cell wall, which constrains viral endemicity across kingdoms.

If you have 2.5 hours to waste, see this moronic display of human idiocy by the “snake was Right” for comparison.

For facts, see: MiR-34a-5p promotes hepatic gluconeogenesis by suppressing SIRT1 expression. It exemplifies the levels of complexity required to link food energy-dependent miRNA-mediated glucose metabolism to feedback loops and ecological adaptations via RNA interference (RNAi). The facts can be compared to stupid theories about natural selection for beneficial mutations or natural selection for energy-dependent codon optimality.

For example, changes in host fitness protect against the virus-driven degradation of messenger RNA, which links mutations to all virus-driven pathology. Fixation of amino acid substitutions in microtubules and constraints on human endogenous retroviruses (HERVs) are the key to longevity in this model:

For comparison, nutritional stress and social stress cause constraint breaking mutations. See: Optimal Nutritional Status for a Well-Functioning Immune System Is an Important Factor to Protect against Viral Infections 4/23/20 and

See also: Pheromonal Regulation of Genetic Processes: Research on the House Mouse  (1994)

The failure to link the metabolism of food to pheromone-regulated feedback loops and regulation of social stress is the epic failure of all stupid theorists. They may kill us all rather than admit they have always been wrong.

Sabine Hossenfelder is a noteworthy exception:

The Big Bang is the simplest explanation to the universe that we know, and it’s probably wrong.

Neo-Darwinian theorists built their theories on claims about cosmology that have never been validated with experimental evidence of top-down energy-dependent causation, which must be linked to the physics of existence via what is known to chemists and molecular biologists.


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