The devil is in the dirt (4)
“…laser beams excited even smaller building blocks within tubulin in microtubules.”
Happy New Year! That links energy-dependent fixation of amino acid substitutions in microtubules to biophysically constrained stem cell Creation and cell type differentiation across kingdoms from microbes to humans during the time since the origin of peptide synthesis at the origin of life via the carbon content of soil bacteria (dirt).
For review: My top tweet from December @microRNApro made 7900 impressions and it can now be viewed in the context of
- the half-life of Carbon 14 (~ 5700 yrs);
- light-activated carbon fixation in cyanobacteria (dirt);
- naturally occurring miRNA-mediated RNA interference (#RNAi); and
- healthy longevity.
For comparison to virus-driven pathology, see: A novel regulator in cancer initiation and progression: long noncoding RNA SHNG9 12/31/22
“Small nucleolar RNA host gene 9 (SNHG9) binds with miRNAs, inducing miRNA downregulation. The downregulated miRNAs enhance downstream target gene expression via ceRNA networks. Dysregulation of SNHG9 is widely observed in tumors and is associated with clinical prognosis features, which makes it a valuable target for cancer biomarkers and therapeutics. Dysregulated SNHG9 in tumor cells also functions in tumor proliferation, colony formation, migration, invasion and inhibition of apoptosis and tumor cell metabolism. This systematic review of SNHG9 in tumors provides new perspectives on cancer diagnosis and treatment.”
For comparison to what is known about virus-driven energy theft and dysregulation of small nucleolar RNA host gene 9 during the past ~5700 yrs, see: Nature Timespiral, a visual misrepresentation of the space-time continuum and Transformer: The Deep Chemistry of Life and Death 7/12/22 by the moronic Nick Lane.
Both fail to link what is known about the energy-dependent miRNA-mediated fixation of amino acid substitutions in supercoiled DNA from light-activated carbon fixation in cyanobacteria to the creation of all soil types. The microbial life-based soil types (dirt) link energy-dependent plant growth from the ATP-dependent Creation of RNA in thymus cells (T-cells) to stem cell Creation and biophysically constrained viral latency via Peptide synthesis at the origin of life 11/13/20, Visualizing a protonated RNA state that modulates microRNA-21 maturation 10/26/20, and Cellulose: A Plant Cell Biology Game for ages 14+