miRNA-mediated epigenetic states (2)

By: James V. Kohl | Published on: January 18, 2023

153,000 indexed publications link the energy-dependent Creation of miRNA-mediated epigenetic states to healthy longevity via Spl elements protect a CpG island from de novo methylation 9/29/94.

They also link the virus-driven degradation of messenger RNA to Loss of epigenetic information as a cause of mammalian aging 1/12/23

Instruction of epigenetic states from DNA sequences 1/16/23 links our claims about RNA-mediated cell type differentiation in our section on molecular epigenetics to naturally occurring RNA interference across kingdoms From Fertilization to Adult Sexual Behavior.

The first irrelevant comments made by theorists include this reminder that epigenetics is mostly genetics underneath and the claim that @SpringerNathan’s labs series of papers on Maize epigenetic variation had shown that awhile ago.

James Hadfield,, co-author of RNA sequencing: the teenage years 7/24/19 added that:

“It’s the sequnce stupid” was the comment from Hillary Coller & @leonidkruglyak
back in 2018 in response to @odom_lab

That comment was based on Species-specific transcription in mice carrying human chromosome 21 9/11/08, which linked the claims of TH Morgan (1910) about nutrient-dependent pheromone-regulated genetic processes of reproduction in flies (1910) to the origin of life and the origin of consciousness via effects of anesthesia on flies and octopuses.

Remember, before his death at age 48, Dr. Zelenko was rightfully concerned that mRNA vaccines may cause cancer. See also Wang, C (2014) “Investigating biomolecular recognition at the cell surface using atomic force microscopy” (2014), which cites Kohl et al., Human pheromones: integrating neuroendocrinology and ethology.

Now that others have integrated what is known to all intelligent serious scientists about how quantum coherence must be linked to coherently organized biology via microRNA-mediated stem cell creation, we will see more attempts to deny that there is No Boundary Really Between Genetic and Epigenetic — Mae-Wan Ho 3/26/15

Theorists will continue to use inferences from mathematical models because of their history of denying everything that was linked from the Creation of sunlight, humidity, and oxygen to the ATP-dependent Creation of RNA and naturally occurring RNA interference in 1964: See: Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation”

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

See also: Energy as information and constrained endogenous RNA interference 2/15/17 (video from Labroots: Precision Medicine Virtual Conference February 22-23. 2017)

Feedback loops link quantized energy as information to biophysically constrained RNA-mediated protein folding chemistry. Light induced energy-dependent changes link angstroms to ecosystems from classical physics to chemistry/chirality and to molecular epigenetics/autophagy.
The National Microbiome Initiative links microbial quorum sensing to the physiology of reproduction via endogenous RNA interference and chromosomal rearrangements. The rearrangements link energy-dependent fixed amino acid substitutions to the Precision Medicine Initiative via genome wide inferences of natural selection.
This detailed representation of energy-dependent natural selection for codon optimality links biologically- based cause and effect from G protein-coupled receptors to RNA-mediated amino acid substitutions and the functional structure of supercoiled DNA. Energy-dependent polycombic ecological adaptations are manifested in supercoiled DNA. Chromosomal inheritance links the adaptations from morphological phenotypes to healthy longevity via behavioral phenotypes.
For contrast, virus-driven energy theft is the link from messenger RNA degradation to negative supercoiling, constraint breaking mutations, and hecatombic evolution. The viral hecatomb links transgenerational epigenetic inheritance from archaea to Zika virus-damaged DNA, which typically is repaired by endogenous RNA interference and fixation of RNA-mediated amino acid substitutions in organized genomes


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