miRNA-mediated epigenetic effects (5)

By: James V. Kohl | Published on: February 10, 2023

See: miRNA-mediated epigenetic effects (4)

On 1/30/23, Four hundred unique sessions on RNA-mediated.com led Facebook (FB) to lift their restrictions on my personal account in time for the FauciFiles drop on Twitter in February. See James Kohl or @microRNApro anytime between now and then for facts that reveal the level of corruption that led to Pfizer’s acquisition of a patent for naturally occurring stem cell creation and all biodiversity on Earth. The patent links energy-dependent fixation of amino acid substitutions in microtubules to the nutrient-dependent pheromone regulated genetic processes of reproduction in cyanobacteria/blue-green algae at the origin of life and the origin of consciousness via intrinsic chirality, epigenetic states, and machine learning. Pfizer bought Trillium and got this patent as part of the deal.

Pheromones and the luteinizing hormone for inducing proliferation of neural stem cells and neurogenesis

Thanks to FB for these memories:

1/27/22 Bacteria build communities using chemical signals comparable to radio waves

See “Darwin’s Radio” for the link to biophysically constrained HERVs.

1/28/22 Researchers discover how lactic acid weakens anti-tumor defenses

Increased acidity has been linked to viral replication since the dawn of Creation.

1/28/22 How worried should you be about the new COVID subvariant?

The number of recently discovered “new” variants links nutrient stress and social stress to reactivation of HERVs.

1/28/22 Many Pathogenic Genetic Variants Don’t Seem to Carry A Big Risk of Disease

What don’t these geneticists understand about naturally-attenuated human endogenous retroviruses HERVs?


I’m willing to bet that no one will read about “Oppositional COMT Val158Met effects on resting state functional connectivity in adolescents and adults” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667398, and link it from suicide prevention to prevention of mass murders via changes in one amino acid substitution.

Ignoring that fact has been linked to my decline in mental health during the past three decades. But obviously, it’s not just about me. I mentioned to a body-builder friend last Friday that I had become suicidal after I stopped taking my testosterone supplement (for 3 days during an illness).

He knew exactly what I was talking about. I’m waiting for him to tell me about the new doctor in town whose practice is focused on “peptide therapy” because I know that “Peptide synthesis at the origin of life” (11/13/20) was linked to life and death differences in species survival and the survival of all individuals since the dawn of God’s Creation.

1/28/22 Scientists have discovered how to stop and control cellular death.

The discovery of the cell death gene in the late 1990’s by researchers working for Abcam was linked to effective treatment of cancer in “Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene” 9/2/11 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166303 Conserved molecular mechanisms have since been linked from the effective treatment of #COVID19 to the effective treatment of all virus-driven pathology via the patent for RNA interference (#RNAi) held by George M. Church et al.


See for example on “…the architecture of RNA-peptide interactions at the origin of life” https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7285048 Footprints of a Singular 22-Nucleotide RNA Ring at the Origin of Life 4/25/20 –published two days after Trump linked God’s Creation of sunlight and humidity to weakened #COVID19. It’s why Biblical Creation is not taught in public schools.


One way to prevent you from learning about the microRNA-mediated cure for all cancers is to eliminate discussion on Twitter.


WHO knew that the delivery of this game for ages 14+ could change the course of history and end the nonsense touted by conspiracy theorists, Communists, and other atheists. Cellulose: A Plant Cell Biology Game


People with schizophrenia are THREE TIMES more likely to die from Covid-19 than those without mental health issues – with old age the only higher risk factor

All virus-driven pathology is microRNA-mediated, including schizophrenia. See: miRNAs and schizophrenia https://pubmed.ncbi.nlm.nih.gov/?term=microrna+schizophrenia&sort=date

For example: “Common schizophrenia risk variants are enriched in open chromatin regions of human glutamatergic neurons


Studying the Symphony of Cells

The human body has more than 37 trillion cells that form elaborate molecular networks. Aviv Regev has dedicated her career to understanding the cell, especially when things go wrong. As EVP, Genentech Research & Early Development, she’s focused on taking insights about the cell into potential treatments for some of the hardest-to-treat diseases. Learn more about Aviv and her work in a special episode of our #podcast, Two Scientists Walk Into a Bar:

The ability to adapt is microRNA-mediated


No one seems willing to mention the contribution that conspiracy theorists made to outcomes like this. They contributed as much as Communists and other atheists because they failed to learn enough about the science in Biblical Genesis that Trump linked from God’s Creation of sunlight and humidity to constraints on #Covid19, which have been linked to proton beam therapy for cancer.

You could say that conspiracy theorists are largely responsible for all virus-driven pathology because they are biologically uninformed science idiots, but you will never get one to admit that.


Genotype: A Mendelian Genetics Game

Excerpt: A worker placement and dice drafting game built upon Gregor Mendel’s work with genetics and pea plants.

I just backed Genotype: A Mendelian Genetics Game on @Kickstarter …. The ability to link God’s Creation of sunlight and water to all biodiversity on Earth via Biblical Genesis and genetics is essential to the understanding how to stop the #Wuhan#coronavirus

I tried to post a link with the comment above and immediately got this response from FB: “Your message couldn’t be sent because it includes content that other people on Facebook have reported as abusive.”


Waiting to see is if Atanas G. Atanasov ever cites my review of microRNA-mediated cell type differentiation in all living genera now that my claims are supported by more than 82,000 published works on microRNAs, which include:

Pro-Angiogenic Activity of Monocytic-Type Myeloid-Derived Suppressor Cells from Balb/C Mice Infected with Echinococcus Granulosus and the Regulatory Role of miRNAs. https://www.karger.com/Article/FullText/495498


In evolution, when a creature developed a new sense such as electrical signals, then many different species followed

New Sense Stimulates New Species, Attention stimulates Neurons


The brain’s system for removing waste is driven primarily by the pulsations of adjoining arteries, University of Rochester neuroscientists and mechanical engineers report in a new study. They also show that changes in the pulsations caused by high blood pressure slow the removal of waste, reducing its efficiency. This might explain the association between high blood pressure and Alzheimer’ disease, the researchers say.

How high blood pressure might contribute to Alzheimer’s


Learn more about mitochondrial dysfunction on the Disease Education page of our updated website today. http://ow.ly/bz5r50k0KlN


https://www.nature.com/articles/s41586-019-0885-0 Autophagic cell death restricts chromosomal instability during replicative crisis reported as: https://medicalxpress.com/news/2019-01-reversal-scientists-cellular-cancer.html “In surprising reversal, scientists find a cellular process that stops cancer before it starts.”

The same energy-dependent microRNA-mediated cellular process stops all pathology before it starts — until the innate immune system is overwhelmed by nutrient stress or social stress that links the virus-driven degradation of messenger RNA from mutations to all pathology.


Comparisons between their use of the term “destructive interference” and use of the term RNA interference must be considered in the context of genetic engineering, which uses viruses to repair DNA damage caused by virus-driven energy theft.

The parallels link electron spin from vibrations in supercoiled DNA to consciousness and from supercoiled DNA to healthy longevity.

Virus-driven energy theft causes “destructive interference” and all pathology. The differences between healthy longevity and pathology are the basis of what must be considered in the context of the Precision Medicine Initiative and National Microbiome Initiative.

Currently, however, alternative facts are the focus of complaints by pseudoscientists who cannot link anything except emergence to the evolution of all biodiversity. Trying to teach them that energy-dependent changes in angstroms to ecosystems are the basis for what is known to serious scientists about all biodiversity is like trying to teach a pig to ring a bell and sing along with the music of life.


Thanks to Anna Di Cosmo for bringing this to my attention. I did know that any dinosaur could display this level of flexibiilty and trained expertise.

I must begin to picture them in a new light. For example Mr. Lane just told me I needed to link temperature and pH from hydrogen-atom transfer in DNA base pairs in solution to dinosaur metabolism and to the pH and temperature dependent-cranking capacity of my motorcycle battery.

The battery was nearly dead as a dinosaur for the same reasons that link classical physics to chemistry and quantum physics to the molecular epigenetics of RNA-mediated cell type differentiation in all living genera.

How could I not have seen this coming from an engineer. Sometimes, they really do know everything required to live to ride, and ride to live. If this dinosaur were still alive, he could probably ride, too.


Metabolic theory predicts whole-ecosystem properties

How do you respond?

You tell the atheists to learn about light-activated carbon fixation and induced fixation of amino acid substitutions that link the sun’s biological energy to biodiversity via the biophysically constrained chemistry of protein folding. That’s how to respond to any pseudoscientific nonsense touted by theoretical physicists or by evolutionary theorists and all atheists.

Prepare for them to tell you “…please keep your theories to yourself ….I don’t need to read this when we have buried one of our babies losses.” — Jennifer Andrews (2/5/23) and “Timing dude. Come on. Have a heart.”–George Koch 2/5/23

Nobel Prize in Physiology or Medicine 1947

“Gerty Cori uncovered the process of cellular energy storage and release, answering a fundamental question about how the body works. Her work transformed the study of biology, proving that molecular chemistry could be applied to the mechanisms of biology.

Read her story.”

Then link the ATP-dependent Creation of RNA from RNA interference (1964) to prevention of all virus-driven diseases via what is known to all intelligent serious scientists about fixation of amino acid substitutions (1964) in microtubules, or glyphosate substitution for glycine, which alters every aspect of naturally occurring viral latency and links virus-driven energy theft to destructive interference.

Then, wait to see what Jennifer Andrews claims caused the stillbirth of her donkey.

Watch for my @microRNApro series about “The Science,” and women who failed to change it.

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