miRNA-mediated epigenetic effects (6)

By: James V. Kohl | Published on: February 10, 2023

mirnas 154,025 results

Parallelized multidimensional analytic framework applied to mammary epithelial cells uncovers regulatory principles in EMT 2/8/23

Simultaneous examination of protein abundance from whole-cells, nucleus, exosomes, secretome & membrane; N-glycosylation, phosphorylation; metabolites; and the miRNA-mRNA balance uncovered the regulatory principles in EMT, which link the virus-driven degradation of messenger RNA to all virus-driven pathology.

For a historical perspective, see: MicroRNA-based regulation of epithelial–hybrid–mesenchymal fate determination 11/5/13

We found that miR-200/ZEB forms a tristable circuit that acts as a ternary switch, driven by miR-34/SNAIL, that is a monostable module that acts as a noise-buffering integrator of internal and external signals.

Everything known to intelligent serious scientists about how internal and external signals are linked to energy-dependent biophysically constrained viral latency across kingdoms was placed into the context of energy-dependent “Bacterial self-organization: co-enhancement of complexification and adaptability in a dynamic environment” 5/7/03

Sex-dimorphic and age-dependent organization of 24-hour gene expression rhythms in humans 2/3/23 linked the claims about complexification and adaptability to refutations of all stupid theories about beneficial mutations via Silencing of genes in cultured Drosophila neurons by RNA interference 7/23/07, which linked the energy-dependent miRNA-mediated Creation of all genotypes and phenotypes to biophysically constrained viral latency via the effects of sunlight and humidity on oxygen-dependent life during the past 5-10,000 years of ecological adaptation. The effects are manifested as sexually dimorphic age-dependent gene expression in species from microbes to humans via what is known about energy-dependent changes in exosomal miRNAs and therapeutic solutions for all virus-driven pathology.

For historical perspective, Nobel Prize in Physiology or Medicine 1947

“Gerty Cori uncovered the process of cellular energy storage and release, answering a fundamental question about how the body works. Her work transformed the study of biology, proving that molecular chemistry could be applied to the mechanisms of biology.

Read her story.

Then link the ATP-dependent Creation of RNA (1964) from RNA interference (#RNAi) to prevention of all virus-driven diseases via what is known to all intelligent serious scientists about fixation of amino acid substitutions (1964) in microtubules, or glyphosate substitution for glycine, which alters every aspect of naturally occurring viral latency. Glyphosate toxicity links virus-driven energy theft to destructive interference in Toxic Legacy: How the Weedkiller Glyphosate Is Destroying Our Health and the Environment (2022)

Watch for the end of this 10-part series about “The Science” of miRNA-mediated epigenetic effects, and see what happened to the men and women who failed to change “The Science” for profit.

For instance, theorists are still touting moronic theories that require people to believe that energy automagically emerged from the cosmic void billions of years ago, and that beneficial mutations somehow led to all extant biodiversity — despite the fact that no experimental evidence of Top-down causation and quantum physics 10/23/18 supports their claims.

See: Comparative Analysis and Data Provenance for 1,113 Bacterial Genome Assemblies 5/2/22

Synonymous variants represent alterations to a coding sequence that does not change the amino acid upon translation. Nonsynonymous variants represent alterations to a coding sequence that does change the amino acid upon translation.

Top-down energy-dependent quantum causation has linked Eukaryotic plankton diversity in the sunlit ocean 5/22/15 to survival of 90% of extant species on Earth via the potential of hydrogen (pH) to constrain the Virus-mediated archaeal hecatomb in the deep seafloor 10/12/16. Energy-dependent fixation of amino acid substitutions in microtubules links the physiology of reproduction to viral latency across kingdoms via synonymous and nonsynonymous variants.

See for comparison: A universal trend of amino acid gain and loss in protein evolution1/19/05

Amino acid composition of proteins varies substantially between taxa and, thus, can evolve.


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