Positive as a proton (1)

By: James V. Kohl | Published on: May 9, 2023

The proton motive force has been linked to all biodiversity on Earth via the physiology of reproduction at the origin of life and the origin of consciousness. Here’s how that was done. Intelligent serious scientists started with light-activated carbon fixation in cyanobacteria and linked the facts to:

MicroRNAs reshape the immunity of insects in response to bacterial infection (indexed 5/8/23)

“One mRNA is likely to be regulated by multiple miRNAs, and a miRNA can control the expression patterns of a diverse set of target mRNAs. As a result, it has become obvious that miRNAs play critical biological roles in a wide range of physiological activities, including cell immune responses, proliferation, differentiation, metabolism, and autophagy.”

The links to autophagy became obvious via the history of indexed published works that linked the ATP-dependent Creation of RNA in regulatory T cells to fixation of amino acid substitutions in microtubules via RNA interference and biophysically constrained viral latency across kingdoms via the honeybee model organism in: Nutrient-dependent/pheromone-controlled adaptive evolution: a model 6/14/13

“Conclusion

An environmental drive evolved from that of nutrient ingestion in unicellular organisms to that of pheromone-controlled socialization in insects. In mammals, food odors and pheromones cause changes in hormones such as LH, which has developmental affects on pheromone-controlled sexual behavior in nutrient-dependent reproductively fit individuals across species of vertebrates.”

More recently, heterogeneity across kingdoms was linked to A phosphate-sensing organelle regulates phosphate and tissue homeostasis 5/3/23, which was reported as New cellular ‘organelle’ discovered inside fruit-fly intestines 5/4/23 and linked to Systematic characterization of small RNAs associated with C. elegans Argonautes 5/5/23 via the conserved molecular mechanisms reported in the molecular epigenetics section of our 1996 Hormones and Behavior review: From Fertilization to Adult Sexual Behavior.

We linked the fact that even the yeast Saccharomyces cerevisiae has a gene-based equivalent of sexual orientation (i.e., a-factor and alpha-factor physiologies) to differences that arose from different epigenetic modifications of an otherwise identical MAT locus (Runge and Zakian, 1996; Wu and Haber, 1995). Theorists hated that fact about sexual orientation.

But, see the recapitulation of our claims in: On the origin and nature of nongenetic information in eumetazoans 5/8/23

“I examine seven nongenetically determined phenomena: placement of locus-specific epigenetic marks on DNA and histones, changes in snRNA expression patterns, neural induction of gene expression, site-specific alternative gene splicing, predator-induced morphological changes, and cultural inheritance. Based on the available evidence, I propose a general model of the common neural origin of all these forms of nongenetic information in eumetazoans.”

Don’t be the last to ask “What were biologically uninformed theorists thinking?” You may be accused of being one of them.


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