Positive as a proton (3)

By: James V. Kohl | Published on: May 11, 2023

In philosophy, naturalism is the idea or belief that only natural laws and forces (as opposed to supernatural ones) operate in the universe.[1]

Most philosophers skip past facts about the energy-dependent origin of life and link moronic theories to the evolution of all species after energy automagically emerged from the cosmic void.

See for comparison:

On Origin of Life, “Stated Clearly” Has Clearly Misled Viewers 5/8/23 (video) and Virus-Derived Small RNAs and microRNAs in Health and Disease 5/9/23

If you would rather avoid the unnecessary suffering and premature death cause by the virus-driven degradation of messenger RNA across kingdoms, see: The role of noncoding RNAs in metabolic reprogramming of cancer cells 5/9/23 and What is life when it is not protected from virus driven entropy 3/30/16

“The anti-entropic force of virucidal ultraviolet light links guanine–cytosine (G⋅C) Watson–Crick base pairing from hydrogen-atom transfer in DNA base pairs in solution to supercoiled DNA, which protects the organized genomes of all living genera from virus-driven entropy. For example, protection of DNA from permanent UV damage occurs in the context of photosynthesis and nutrient-dependent RNA-directed DNA methylation, which links RNA-mediated amino acid substitutions to DNA repair. In the context of thermodynamic cycles of protein biosynthesis and degradation, DNA repair enables the de novo creation of G protein coupled receptors (GPCRs). Olfactory receptor genes are GPCRs. The de novo creation of olfactory receptor genes links chemotaxis and phototaxis from foraging behavior to social behavior in species from microbes to humans. Foraging behavior links ecological variation to ecological adaptation in the context of this atoms to ecosystems model of biophysically constrained energy-dependent RNA-mediated protein folding chemistry. Protein folding chemistry links nutrient-dependent microRNAs from microRNA flanking sequences to energy transfer and cell type differentiation in the context of adhesion proteins, and supercoiled DNA that protects all organized genomes from virus-driven entropy.”

Reminder: The origin of religion (non-naturalism) links facts about light-activated carbon fixation in cyanobacteria and their physiology of pheromone-regulated genetic processes of reproduction to RNA interference (RNAi) across kingdoms via the logic and study of entomology, etymology and epistemology.

1) Entomology is the branch of zoology that links the nutrient-dependent pheromone regulated genetic processes of reproduction in insects to 2) etymology, which bridges the gaps from the study of the origin of words (and the way in which their meanings have changed throughout history) to experimental evidence that justifies religious beliefs via comparison to stupid theories via 3) epistemology.

See: Footprints of a Singular 22-Nucleotide RNA Ring at the Origin of Life 4/25/20 for comparison to the pseudoscientific nonsense in Study Suggests Catalyst for Human Brain Evolution 4/27/23

“More than a million years ago, large chunks of the human genome were rearranged—a chance event during egg or sperm formation that led to the deletion, duplication, or reversal of sections of DNA. Those structural variants, researchers have now discovered, likely set off a cascade of other rapid changes in human DNA that may underlie uniquely human features, particularly the brain.”

For comparison to the nonsense about Zoonomia 4/27/23, see: Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants, which was reported as: Past 5,000 years prolific for changes to human genome 11/28/12

“The findings confirm their earlier work suggesting that the majority of variants, including potentially harmful ones, were picked up during the past 5,000–10,000 years.”

Compare the experimental evidence of sequence constraints via Spirocyclic Chromenopyrazole Inhibitors Disrupting the Interaction between the RNA-binding protein LIN28 and Let-7 5/2/23

“We report herein the identification of new LIN28 inhibitors utilizing a spirocyclization strategy based on a chromenopyrazole scaffold.”

Watch for more indexed published articles on PubMed that link spirocyclization 2,131 results and miRNAs 157,658 results to biophysically constrained viral latency and healthy longevity via what is known to all intelligent serious scientists.

See for example: Prediction of Cancer Metastasis using Correlations between miRNAs and Competing Endogenous RNAs 5/10/23

“…differential correlations of miRNAs and target RNAs are much more powerful and stable than expressions of known metastasis predictive genes in predicting distant metastasis as well as lymph node metastasis.”

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